Diagnosis of hypersplenism with the epinephrine stimulation test: 23 Years of experience at a tertiary care hospital

Swiss Medical Weekly

Volumn 142, Issue 1, 2012, Pages

  Misselwitz, Benjamin ^a   Bachli, Esther B ^b   Kaiser, Philipp ^a   Fehr, Jor̈g ^a   Goede, Jeroen S ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b Spital Uster   (Switzerland)

Author keywords

Cytopenia; Epinephrine stimulation test; Hypersplenism; Neutropenia; Splenomegaly; Thrombocytopenia

Indexed keywords

ADRENALIN; DIAGNOSTIC AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; EPINEPHRINE STIMULATION TEST; FEMALE; HEMATOLOGIC MALIGNANCY; HUMAN; HYPERSPLENISM; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; PROVOCATION TEST; SPLEEN SIZE; SPLENECTOMY; THROMBOCYTE; VALIDATION PROCESS; LEUKOCYTE COUNT; MIDDLE AGED; NEUTROPENIA; PATHOPHYSIOLOGY; RETROSPECTIVE STUDY; SPLEEN; SPLENOMEGALY; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; AGED; EPINEPHRINE; FEMALE; HUMANS; HYPERSPLENISM; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NEUTROPENIA; PLATELET COUNT; RETROSPECTIVE STUDIES; SPLEEN; SPLENECTOMY; SPLENOMEGALY; THROMBOCYTOPENIA; YOUNG ADULT;

EID: 84856773799     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: 10.4414/smw.2011.13324     Document Type: Article

References (27)

1. Peck-Radosavljevic M. Hypersplenism. Eur J Gastroenterol Hepatol. 2001;13(4):317-23.
2. Bowdler AJ. Splenomegaly and hypersplenism. Clin Haematol. 1983;12(2):467-88.
3. Greer JP, Foerster J, Rodgers GM, Paraskevas F, Glader B, Arber DA, et al. Winthrobe's Clinical Hematology, 12th edition. 2009.
4. Aster RH. Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia. J Clin Invest. 1966;45(5):645-57.
5. Martin DW, Woeber KA, Smith LH. Hypersplenism. Calif Med. 1973;118(1):24-9.
6. Brubaker LH, Johnson CA. Correlation of splenomegaly and abnormal neutrophil pooling (margination). J Lab Clin Med. 1978;92(4):508-15. (Pubitemid 9027456)
7. Bishop CR, Rothstein G, Ashenbrucker HE, Athens JW. Leukokinetic studies. XIV. Blood neutrophil kinetics in chronic, steady-state neutropenia. J Clin Invest. 1971;50(8):1678-89.
8. Schaffner A, Fehr J. Granulocyte demargination by epinephrine in evaluation of hypersplenic states. Scand J Haematol. 1981;27(4):225-30. (Pubitemid 12203146)
9. Fehr J, Grossmann HC. Disparity between circulating and marginated neutrophils: evidence from studies on the granulocyte alkaline phosphatase, a marker of cell maturity. Am J Hematol. 1979;7(4):369-79. (Pubitemid 10095970)
10. Schaffner A, Augustiny N, Otto RC, Fehr J. The hypersplenic spleen. A contractile reservoir of granulocytes and platelets. Arch Intern Med. 1985;145(4):651-4. (Pubitemid 15077925)
11. Downey MT. Estimation of splenic weight from ultrasonographic measurements. Can Assoc Radiol J. 1992;43(4):273-7.
12. O'Reilly RA. Splenomegaly in 2,505 patients at a large university medical center from 1913 to 1995. 1963 to 1995: 449 patients. West J Med. 1998;169(2):88-97.
13. Kraus MD. Splenic histology and histopathology: an update. Semin Diagn Pathol. 2003;20(2):84-93. (Pubitemid 36992880)
14. Gielchinsky Y, Elstein D, Hadas-Halpern I, Lahad A, Abrahamov A, Zimran A. Is there a correlation between degree of splenomegaly, symptoms and hypersplenism? A study of 218 patients with Gaucher disease. Br J Haematol. 1999;106(3):812-.
15. Shi BM, Wang XY, Mu QL, Wu TH, Xu J. Value of portal hemodynamics and hypersplenism in cirrhosis staging. World J Gastroenterol. 2005;11(5):708-11. (Pubitemid 40220763)
16. Liangpunsakul S, Ulmer BJ, Chalasani N. Predictors and implications of severe hypersplenism in patients with cirrhosis. Am J Med Sci. 2003;326(3):111-6. (Pubitemid 37122293)
17. Chikamori F, Nishida S, Selvaggi G, Tryphonopoulos P, Moon JI, Levi DM, et al. Effect of liver transplantation on spleen size, collateral veins, and platelet counts. World J Surg;34(2):320-6.
18. Pursnani KG, Sillin LF, Kaplan DS. Effect of transjugular intrahepatic portosystemic shunt on secondary hypersplenism. Am J Surg. 1997;173(3):169-73. (Pubitemid 27163842)
19. Alvarez OA, Lopera GA, Patel V, Encarnacion CE, Palmaz JC, Lee M. Improvement of thrombocytopenia due to hypersplenism after transjugular intrahepatic portosystemic shunt placement in cirrhotic patients. Am J Gastroenterol. 1996;91(1):134-7. (Pubitemid 26026052)
20. Zhu K, Meng X, Li Z, Huang M, Guan S, Jiang Z, et al. Partial splenic embolization using polyvinyl alcohol particles for hypersplenism in cirrhosis: a prospective randomized study. Eur J Radiol. 2008;66(1):100-6. (Pubitemid 351434513)
21. Lee CM, Leung TK, Wang HJ, Lee WH, Shen LK, Liu JD, et al. Evaluation of the effect of partial splenic embolization on platelet values for liver cirrhosis patients with thrombocytopenia. World J Gastroenterol. 2007;13(4):619-22.
22. Wang HY, Shih SC, Lin SC, Chang WS, Wang TE, Lin FJ, et al. Partial splenic embolization: 12-month hematological effects and complications. Hepatogastroenterology. 2008;55(86-87):1838-42.
23. Hayashi H, Beppu T, Masuda T, Mizumoto T, Takahashi M, Ishiko T, et al. Predictive factors for platelet increase after partial splenic embolization in liver cirrhosis patients. J Gastroenterol Hepatol. 2007;22(10):1638-42. (Pubitemid 47383343)
24. Feng K, Ma K, Liu Q, Wu Q, Dong J, Bie P. Randomized clinical trial of splenic radiofrequency ablation versus splenectomy for severe hypersplenism. Br J Surg. 2011;98(3):354-61.
25. Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, et al. Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008;48(6):1000-7.
26. Blendis LM, Clarke MB, Williams R. Effect of splenectomy on the haemodilutional anaemia of splenomegaly. Lancet. 1969;1(7599):795-8.
27. Wani NA, Parray FQ. Splenectomy in idiopathic hypersplenism. Int Surg. 2006;91(3):157-61. (Pubitemid 44784344)