Fulminant liver failure in Wilson's disease with histologic features of postinfantile giant cell hepatitis; Cytomegalovirus as the trigger for both?

European Journal of Gastroenterology and Hepatology

Volumn 24, Issue 3, 2012, Pages 328-331

  Welte, Stefan ^a   Gagesch, Michael ^c   Weber, Achim ^d   Longerich, Thomas ^b   Millonig, Gunda ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Acute liver failure; copper storage; cytomegalovirus; liver biopsy; liver transplantation; postinfantile giant cell hepatitis; viral trigger

Indexed keywords

COPPER;

ADULT; ARTICLE; CASE REPORT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FULMINANT HEPATIC FAILURE; GIANT CELL; HEPATIC ENCEPHALOPATHY; HEPATITIS; HUMAN; HUMAN TISSUE; INFECTIOUS MONONUCLEOSIS; JAUNDICE; LIVER BIOPSY; LIVER TRANSPLANTATION; MALE; PRIORITY JOURNAL; SEROLOGY; WILSON DISEASE;

ADOLESCENT; CYTOMEGALOVIRUS INFECTIONS; GIANT CELLS; HEPATITIS; HEPATITIS, VIRAL, HUMAN; HEPATOLENTICULAR DEGENERATION; HUMANS; LIVER FAILURE, ACUTE; MALE;

EID: 84856762507     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e3283506843     Document Type: Article

References (16)

1. Ozcay F, Canan O, Akcan B, Bilezikci B. Hepatitis A super infection as a cause of liver failure in a child with Wilson's disease. Turk J Pediatr 2007; 49:199-202. (Pubitemid 47299806)
2. Zandman-Goddard G, Weiss P, Avidan B, Bar-Meir S, Shoenfeld Y. Acute varicella infection heralding Wilsonian crisis. J Clin Gastroenterol1994; 18:265-266. (Pubitemid 24114462)
3. Okada T, Shiono Y, Kaneko Y, Miwa K, Hasatani K, Hayashi Y, et al. High prevalence of fulminant hepatic failure among patients with mutant alleles for truncation of ATP7B in Wilson's disease. Scand J Gastroenterol 2010; 45:1232-1237.
4. Fimmel CJ, Guo L, Compans RW, Brunt EM, Hickman S, Perrillo RR, Mason AL. A case of syncytial giant cell hepatitis with features of a paramyxoviral infection. Am J Gastroenterol 1998; 93:1931-1937. (Pubitemid 29071708)
5. Hicks J, Barrish J, Zhu SH. Neonatal syncytial giant cell hepatitis with paramyxoviral-like inclusions. Ultrastruct Pathol 2001; 25:65-71. (Pubitemid 32182096)
6. Bruha R, Marecek Z, Pospisilova L, Nevsimalova S, Vitek L, Martasek P, et al. Long-term follow-up of Wilson disease: natural history, treatment, mutations analysis and phenotypic correlation. Liver Int 2011; 31:83-91.
7. Koukoulis G, Mieli-Vergani G, Portmann B. Infantile liver giant cells: immunohistological study of their proliferative state and possible mechanisms of formation. Pediatr Dev Pathol 1999; 2:353-359. (Pubitemid 29290851)
8. Fang JW, Gonzalez-Peralta RP, Chong SK, Lau GM, Lau JY. Hepatic expression of cell proliferation markers and growth factors in giant cell hepatitis: implications for the pathogenetic mechanisms involved. J Pediatr Gastroenterol Nutr 2011; 52:65-72.
9. Kryczka W, Walewska-Zielecka B, Dutkiewicz E. Acute seronegative hepatitis C manifesting itself as adult giant cell hepatitis - a case report and review of literature. Med Sci Monit 2003; 9 (Suppl 3):29-31.
10. Potenza L, Luppi M, Barozzi P, Rossi G, Cocchi S, Codeluppi M, et al. HHV-6A in syncytial giant-cell hepatitis. N Engl J Med 2008; 359:593-602.
11. Phillips MJ, Blendis LM, Poucell S, Patterson J, Petric M, Roberts E, et al. Syncytial giant-cell hepatitis. Sporadic hepatitis with distinctive pathological features, a severe clinical course, and paramyxoviral features. N Engl J Med 1991; 324:455-460.
12. Moreno-Otero R, Trapero-Marugan M, Garcia-Buey L, Garcia-Sancchez A. Drug-induced postinfantile giant cell hepatitis. Hepatology 2010; 52: 2245-2246.
13. Estradas J, Pascual-Ramos V, Martinez B, Uribe M,Torre A. Autoimmune hepatitis with giant-cell transformation. Ann Hepatol 2009; 8:68-70.
14. Kuntzen T, Friedrichs N, Fischer HP, Eis-Hübinger AM, Sauerbruch T, Spengler U. Postinfantile giant cell hepatitis with autoimmune features following a human herpesvirus 6-induced adverse drug reaction. Eur J Gastroenterol Hepatol 2005; 17:1131-1134. (Pubitemid 41424010)
15. Bianchi L,Terracciano LM. Giant cell hepatitis in adults. Praxis (Bern 1994) 1994; 83:1237-1241.
16. Lau JY, Koukoulis G, Mieli-Vergani G, Portmann BC, Williams R. Syncytial giant-cell hepatitis - a specific disease entity? J Hepatol 1992; 15: 216-219.