Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant

Leukemia

Volumn 26, Issue 1, 2012, Pages 170-172

  Ibbotson, R ^a   Athanasiadou, A ^b   Sutton, L A ^c   Davis, Z ^a   Gardiner, A ^a   Baliakas, P ^b   Gunnarsson, R ^c   Anagnostopoulos, A ^b   Juliusson, G ^d   Rosenquist, R ^c   Oscier, D ^a   Stamatopoulos, K ^b,e  

^a ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

^b G PAPANICOLAOU HOSPITAL   (Greece)

^c UPPSALA UNIVERSITY   (Sweden)

^d LUND UNIVERSITY   (Sweden)

^e INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; IMMUNOGLOBULIN G;

ADULT; AGED; ANTIGEN EXPRESSION; CHROMOSOME 12; CHROMOSOME 19; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC ASSOCIATION; HUMAN; IMMUNOGLOBULIN HEAVY CHAIN GENE; KARYOTYPE; LETTER; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRISOMY;

ADULT; AGED; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; HUMANS; IMMUNOGLOBULIN G; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; TRISOMY;

EID: 84856761225     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.186     Document Type: Letter

References (8)

1. Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916. (Pubitemid 32064784)
2. Athanasiadou A, Stamatopoulos K, Tsompanakou A, Gaitatzi M, Kalogiannidis P, Anagnostopoulos A et al. Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis. Cancer Genet Cytogenet 2006; 168: 109-119.
3. Juliusson G, Merup M. Cytogenetics in chronic lymphocytic leukemia. Semin Oncol 1998; 25: 19-26. (Pubitemid 28090908)
4. Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, Radlwimmer B et al. Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 2004; 101: 1039-1044. (Pubitemid 38160580)
5. Sellmann L, Gesk S, Walter C, Ritgen M, Harder L, Martin-Subero JI et al. Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia. Br J Haematol 2007; 138: 217-220. (Pubitemid 46976322)
6. Athanasiadou A, Stamatopoulos K, Gaitatzi M, Stavroyianni N, Fassas A, Anagnostopoulos A. Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins. Haematologica 2008; 93: 473-474. (Pubitemid 351398656)
7. Martin-Subero JI, Ibbotson R, Klapper W,Michaux L, Callet-Bauchu E, Berger F et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia 2007; 21: 1532-1544. (Pubitemid 46969871)
8. Chapiro E, Radford-Weiss I, Bastard C, Luquet I, Lefebvre C, Callet-Bauchu E et al. The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia. Leukemia 2008; 22: 2123-2127.