Tiotropium improves walking endurance in COPD

European Respiratory Journal

Volumn 39, Issue 2, 2012, Pages 265-271

  Bedard M E ^a   Brouillard, C ^a   Pepin, V ^b   Provencher, S ^a   Milot, J ^a   Lacasse, Y ^a   Leblanc, P ^a   Maltais, F ^a  

^a LAVAL UNIVERSITY   (Canada)

^b Centre de Recherche Hopital Du Sacre Coeur de Montreal   (Canada)

Author keywords

Bronchodilation; Chronic obstructive pulmonary disease; Exercise; Shuttle walking test; Tiotropium; Walking

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; LONG ACTING DRUG; PLACEBO; SHORT ACTING DRUG; TIOTROPIUM BROMIDE;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; ENDURANCE; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; INSPIRATORY CAPACITY; LUNG FUNCTION TEST; LUNG VENTILATION; MALE; PARALLEL DESIGN; PATIENT MONITORING; PHYSICAL CAPACITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPEAT PROCEDURE; RESPIRATORY TRACT PARAMETERS; TIDAL VOLUME; TREATMENT DURATION; TREATMENT RESPONSE; WALKING;

AGED; BRONCHODILATOR AGENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; PHYSICAL ENDURANCE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; SCOPOLAMINE DERIVATIVES; TREATMENT OUTCOME; WALKING;

EID: 84856760221     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00059511     Document Type: Article

References (31)

1. O'Donnell DE, Flüge T, Gerken F, et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 2004; 23: 832-840. (Pubitemid 38807355)
2. O'Donnell DE, Voduc N, Fitzpatrick M, et al. Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur Respir J 2004; 24: 86-94. (Pubitemid 39029073)
3. Maltais F, Hamilton A, Marciniuck D, et al. Improvements in symptom-limited exercise performance over eight hours with once-daily tiotropium in patients with COPD. Chest 2005; 128: 1168-1178. (Pubitemid 41324392)
4. Neder JA, Fuld JP, Overend T, et al. Effects of formoterol on exercise tolerance in severely disabled patients with COPD. Respir Med 2007; 101: 2056-2064. (Pubitemid 47324257)
5. Maltais F, Celli B, Casaburi R, et al. Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD. Respir Med 2011; 105: 580-587.
6. Pepin V, Saey D, Whittom F, et al. Walking versus cycling: sensitivity to bronchodilation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005; 172: 1517-1522. (Pubitemid 43076539)
7. Brouillard C, Pepin V, Milot J, et al. Endurance shuttle walking test: responsiveness to salmeterol in COPD. Eur Respir J 2008; 31: 579-584.
8. Pepin V, Brodeur J, Lacasse Y, et al. Six-minute walking versus shuttle walking: responsiveness to bronchodilation in chronic obstructive pulmonary disease. Thorax 2007; 63: 291-298. (Pubitemid 46580570)
9. O'Donnell DE, Travers J, Webb KA, et al. Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD. Eur Respir J 2009; 34: 866-874.
10. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005; 26: 319-338. (Pubitemid 41079078)
11. Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J 2005; 26: 948-968. (Pubitemid 41632054)
12. Macintyre N, Crapo RO, Viegi G, et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 2005; 26: 720-735. (Pubitemid 41448672)
13. Quanjer PH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests, european community for steel and coal. Official statement of the European Respiratory Society. Eur Respir J 1993; 6: Suppl. 16, 5-40.
14. Singh SJ, Morgan MD, Scott S, et al. Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax 1992; 47: 1019-1024. (Pubitemid 23011018)
15. Revill SM, Morgan MD, Singh SJ, et al. The endurance shuttle walk: a new field test for the assessment of endurance capacity in chronic obstructive pulmonary disease. Thorax 1999; 54: 213-222. (Pubitemid 29110500)
16. Guyatt GH, Pugsley S, Sullivan MJ, et al. Effect of encouragement on walking test performance. Thorax 1984; 39: 818-822. (Pubitemid 14022730)
17. Pepin V, Laviolette L, Brouillard C, et al. Significance of changes in endurance shuttle walking performance. Thorax 2011; 66: 115-120.
18. Borg G. Psychophysical bases of perceived exertion. Med Sci Sports Exer 1982; 14: 377-381. (Pubitemid 13215050)
19. Zhang X, Waterman LA, Ward J, et al. Advantages of endurance treadmill walking compared with cycling to assess bronchodilator therapy. Chest 2010; 137: 1354-1361.
20. Man WD, Soliman MG, Gearing J, et al. Symptoms and quadriceps fatigability after walking and cycling in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003; 168: 562-567. (Pubitemid 37088599)
21. Saey D, Debigaré R, LeBlanc P, et al. Contractile leg fatigue after cycle exercise: a factor limiting exercise in patients with COPD. Am J Respir Crit Care Med 2003; 168: 425-430. (Pubitemid 37046870)
22. Deschênes D, Pepin V, Saey D, et al. Locus of symptom limitation and exercise response to bronchodilation in chronic obstructive pulmonary disease. J Cardiopulm Rehabil Prev 2008; 28: 208-214.
23. Verkindre C, Bart F, Aguilaniu B, et al. The effect of tiotropium on hyperinflation and exercise capacity in chronic obstructive pulmonary disease. Respiration 2006; 73: 420-427.
24. Oga T, Nishimura K, Tsukino M, et al. The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests. Am J Respir Crit Care Med 2000; 161: 1897-1901. (Pubitemid 30418126)
25. Okudan N, Gok M, Gokbel H, et al. Single dose of tiotropium improves the 6-minute walk distance in chronic obstructive pulmonary disease. Lung 2006; 184: 201-204. (Pubitemid 44477405)
26. Redelmeier DA, Bayoumi AM, Goldstein RS, et al. Interpreting small differences in functional status: the six-minute walk test in chronic lung disease patients. Am J Respir Crit Care Med 1997; 155: 1278-1282. (Pubitemid 27172771)
27. Singh SJ, Jones P, Evans R, et al. The minimum clinically important improvement for the incremental shuttle walking test. Thorax 2008; 63: 775-777.
28. O'Donnell DE, Lam M, Webb KA. Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: 542-549. (Pubitemid 29380670)
29. Marin JM, Carrizo SJ, Gascon M, et al. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163: 1395-1399. (Pubitemid 32506605)
30. O'Donnell DE, Sciurba F, Celli B, et al. Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPD. Chest 2006; 130: 647-656. (Pubitemid 44423592)
31. Tashkin DP, Celli B, Senn S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 2008; 359: 1543-1554.