Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction

Digestive Diseases and Sciences

Volumn 57, Issue 1, 2012, Pages 250-253

  Hoentjen, Frank ^a,b   Hanauer, Stephen B ^a   De Boer, Nanne K ^c   Rubin, David T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

6 Mercaptopurine; Allopurinol; Azathioprine; TPMT; Ulcerative colitis

Indexed keywords

6 METHYLTHIOINOSINE; ALANINE AMINOTRANSFERASE; ALLOPURINOL; CORTICOSTEROID; HYDROCORTISONE; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METHYLPREDNISOLONE; THIOGUANOSINE; THIOPURINE METHYLTRANSFERASE;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BONE MARROW TOXICITY; CASE REPORT; CORTICOSTEROID THERAPY; DRUG DOSE REDUCTION; DRUG METABOLISM; DRUG SUBSTITUTION; DRUG WITHDRAWAL; HEMATOCHEZIA; HUMAN; HYPERTRANSAMINASEMIA; LIVER TOXICITY; MALE; PRIORITY JOURNAL; PROCTITIS; RECTUM BIOPSY; RECURRENCE FREE SURVIVAL; RECURRENT DISEASE; REMISSION; TREATMENT RESPONSE; ULCERATIVE COLITIS;

6-MERCAPTOPURINE; ALLOPURINOL; ANTIMETABOLITES; COLITIS, ULCERATIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; GUANINE NUCLEOTIDES; HUMANS; LIVER; MALE; METHYLTRANSFERASES; STEROIDS; THIONUCLEOTIDES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84856755492     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1999-x     Document Type: Article

References (25)

1. B Jharap ML Seinen NK de Boer, et al. 2010 Thiopurine therapy in inflammatory bowel disease patients: analyses of two 8-year intercept cohorts Inflamm Bowel Dis 16 1541 1549 20155846 10.1002/ibd.21221 1:STN:280: DC%2BC3cjnvFSqsw%3D%3D
2. MC Dubinsky S Lamothe HY Yang, et al. 2000 Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease Gastroenterology 118 705 713 10734022 10.1016/S0016-5085(00)70140-5 1:CAS:528:DC%2BD3cXis1ens7w%3D (Pubitemid 30171620)
3. C Cuffari S Hunt T Bayless 2001 Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease Gut 48 642 646 11302961 10.1136/gut.48.5.642 1:CAS:528: DC%2BD3MXjvVansL8%3D (Pubitemid 32378583)
4. MT Osterman R Kundu GR Lichtenstein JD Lewis 2006 Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis Gastroenterology 130 1047 1053 16618398 10.1053/j.gastro.2006.01. 046 1:CAS:528:DC%2BD28XksFWmur8%3D
5. LP Gilissen LJ Derijks HM Verhoeven, et al. 2007 Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease Dig Liver Dis 39 182 186 16880012 10.1016/j.dld.2006.05.026 1:CAS:528:DC%2BD2sXktFWgs70%3D (Pubitemid 46117922)
6. ES Collie-Duguid SC Pritchard RH Powrie, et al. 1999 The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations Pharmacogenetics 9 37 42 10208641 10.1097/00008571-199902000-00006 1:CAS:528:DyaK1MXjtlyqsLw%3D (Pubitemid 29176722)
7. RM Engen S Marsh DJ Van Booven HL McLeod 2006 Ethnic differences in pharmacogenetically relevant genes Curr Drug Targ 7 1641 1648 10.2174/138945006779025446 1:CAS:528:DC%2BD28XhtlSisrnI (Pubitemid 44873726)
8. YY Hon MY Fessing CH Pui MV Relling EY Krynetski WE Evans 1999 Polymorphism of the thiopurine S-methyltransferase gene in African-Americans Hum Mol Genet 8 371 376 9931346 10.1093/hmg/8.2.371 1:CAS:528:DyaK1MXht12ktro%3D (Pubitemid 29054281)
9. MM Ameyaw ES Collie-Duguid RH Powrie D Ofori-Adjei HL McLeod 1999 Thiopurine methyltransferase alleles in British and Ghanaian populations Hum Mol Genet 8 367 370 9931345 10.1093/hmg/8.2.367 1:CAS:528:DyaK1MXht12ksbo%3D (Pubitemid 29054280)
10. RA Booth MT Ansari E Loit, et al. 2011 Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review Ann Intern Med 154 814 823 21690596
11. E Schaeffeler C Fischer D Brockmeier, et al. 2004 Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants Pharmacogenetics 14 407 417 15226673 10.1097/01.fpc.0000114745.08559.db 1:CAS:528:DC%2BD2cXlt1Cktrs%3D (Pubitemid 38971231)
12. JP Gisbert F Gomollon 2008 Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review Am J Gastroenterol 103 1783 1800 18557712 10.1111/j.1572-0241.2008.01848.x
13. LY Kwan SM Devlin JM Mirocha KA Papadakis 2008 Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease Dig Liver Dis 40 425 432 18304898 10.1016/j.dld.2008.01.003 1:CAS:528:DC%2BD1cXnvVOrsb8%3D
14. A Ansari C Hassan J Duley, et al. 2002 Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease Aliment Pharmacol Ther 16 1743 1750 12269967 10.1046/j.1365-2036.2002.01353.x 1:CAS:528:DC%2BD38XotlOhsb0%3D
15. MP Sparrow SA Hande S Friedman, et al. 2005 Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine Aliment Pharmacol Ther 22 441 446 16128682 10.1111/j.1365-2036.2005.02583.x 1:CAS:528: DC%2BD2MXhtVykt73L (Pubitemid 41248111)
16. MP Sparrow SA Hande S Friedman D Cao SB Hanauer 2007 Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine Clin Gastroenterol Hepatol 5 209 214 17296529 10.1016/j.cgh.2006.11.020 1:CAS:528:DC%2BD2sXjtlKjsrs%3D (Pubitemid 46216945)
17. A Ansari N Patel J Sanderson J O'Donohue JA Duley TH Florin 2010 Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease Aliment Pharmacol Ther 31 640 647 20015102 10.1111/j.1365-2036.2009.04221.x 1:CAS:528:DC%2BC3cXktlSmsL0%3D
18. RW Rundles 1966 Effects of allopurinol on 6-mercaptopurine therapy in neoplastic diseases Ann Rheum Dis 25 655 656 5226511 1:STN:280: DyaF2s%2Fpt1aiug%3D%3D
19. P Chocair J Duley HA Simmonds, et al. 1993 Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen Lancet 342 83 84 8100914 10.1016/0140-6736(93)91287-V 1:STN:280:DyaK3szhs1Ojsw%3D%3D (Pubitemid 23192425)
20. PA Blaker M Arenas L Fairbanks P Irving AM Marinaki J Sanderson 2011 A biochemical mechanism for the role of allopurinol in TPMT inhibition DDW 140 S769
21. JA Duley PR Chocair TH Florin 2005 Observations on the use of allopurinol in combination with azathioprine or mercaptopurine Aliment Pharmacol Ther 22 1161 1162 16305731 10.1111/j.1365-2036.2005.02703.x 1:STN:280: DC%2BD2MnisVKntQ%3D%3D (Pubitemid 41779525)
22. RL Roberts RB Gearry MV Bland, et al. 2008 Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity Pharmacogenet Genomics 18 434 438 18408566 10.1097/FPC.0b013e3282f85e47 1:CAS:528:DC%2BD1cXksFynu7k%3D (Pubitemid 351535944)
23. M Lindqvist S Haglund S Almer, et al. 2004 Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity Pharmacogenetics 14 261 265 15083071 10.1097/00008571-200404000-00006 1:CAS:528:DC%2BD2cXksVWlsbs%3D (Pubitemid 38530518)
24. SK Kham CK Soh DC Aw AE Yeoh 2009 TPMT 26 (208F → L), a novel mutation detected in a Chinese Br J Clin Pharmacol 68 120 123 19660010 10.1111/j.1365-2125.2009.03405.x 1:CAS:528:DC%2BD1MXhtVGjtr3N
25. Y Gonzalez-Lama F Bermejo A Lopez-Sanroman, et al. 2011 Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients Aliment Pharmacol Ther 34 544 5554 21722149 10.1111/j.1365-2036.2011. 04756.x 1:CAS:528:DC%2BC3MXhtFKjtLbP