Immunization with N-propionyl polysialic acid-KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci

Cancer Immunology, Immunotherapy

Volumn 61, Issue 1, 2012, Pages 9-18

  Krug, Lee M ^a   Ragupathi, Govind ^b   Hood, Chandra ^b   George, Constantine ^b   Hong, Feng ^b   Shen, Ronglai ^a   Abrey, Lauren ^b   Jennings, Harold J ^c   Kris, Mark G ^a   Livingston, Philip O ^b  

^a Department of Obstetrics Gynecology   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Minimal residual disease; Polysialic acid; Small cell lung cancer

Indexed keywords

CANCER VACCINE; IMMUNOGLOBULIN M; KEYHOLE LIMPET HEMOCYANIN N PROPIONYL POLYSIALIC ACID CONJUGATE; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ARTICLE; ATAXIA; BACTERICIDAL ACTIVITY; CANCER CELL; CANCER IMMUNIZATION; CANCER SURVIVAL; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG SAFETY; FATIGUE; FEMALE; FEVER; FLUORESCENCE ACTIVATED CELL SORTING; HEADACHE; HUMAN; HUMAN CELL; IMMUNOGENICITY; INJECTION SITE REACTION; LUNG SMALL CELL CANCER; MALE; NAUSEA; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; RADIATION PNEUMONIA; SENSORY NEUROPATHY; SURVIVAL RATE; VOMITING;

AGED; ANIMALS; BLOOD BACTERICIDAL ACTIVITY; CANCER VACCINES; DISEASE PROGRESSION; FEMALE; HEMOCYANIN; HUMANS; IMMUNOGLOBULIN M; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEISSERIA MENINGITIDIS, SEROGROUP B; RABBITS; SIALIC ACIDS; SMALL CELL LUNG CARCINOMA; SURVIVAL ANALYSIS;

EID: 84856743910     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-011-1083-6     Document Type: Article

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