Combined methotrexate-dactinomycin: An effective therapy for low-risk gestational trophoblastic neoplasia

Gynecologic Oncology

Volumn 124, Issue 3, 2012, Pages 553-557

  Eiriksson, Lua ^a   Wells, Tiffany ^b   Steed, Helen ^a   Schepansky, Alexandra ^a   Capstick, Valerie ^a   Hoskins, Paul ^b   Pike, Judith ^b   Swenerton, Kenneth ^b  

^a CROSS CANCER INSTITUTE   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Adverse effects; Drug therapy; Gestational trophoblastic disease; Gestational trophoblastic neoplasms; Recurrence; Remission induction

Indexed keywords

CHORIONIC GONADOTROPIN; DACTINOMYCIN; METHOTREXATE;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ALOPECIA; APHTHOUS STOMATITIS; ARTICLE; BLOOD TOXICITY; CANCER CHEMOTHERAPY; CHEMOTHERAPY INDUCED EMESIS; CREATININE CLEARANCE; CURETTAGE; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFICACY; FATIGUE; FEMALE; HUMAN; HYSTERECTOMY; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPHIL COUNT; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; SIDE EFFECT; TREATMENT DURATION; TROPHOBLASTIC TUMOR;

ADOLESCENT; ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DACTINOMYCIN; FEMALE; GESTATIONAL TROPHOBLASTIC DISEASE; HUMANS; METHOTREXATE; MIDDLE AGED; PREGNANCY; RETROSPECTIVE STUDIES; RISK FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84856717338     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.10.036     Document Type: Article

References (16)

1. J.T. Soper Gestational trophoblastic disease Obstet Gynecol 108 1 2006 176 187
2. H.O. Smith Gestational trophoblastic disease epidemiology and trends Clin Obstet Gynecol 46 3 2003 541 556
3. A.J. Wolfberg, C. Feltmate, D.P. Goldstein, R.S. Berkowitz, and E. Lieberman Low risk of relapse after achieving undetectable HCG levels in women with complete molar pregnancy Obstet Gynecol 104 3 2004 551 554
4. S. Goto, A. Yamada, T. Ishizuka, and Y. Tomoda Development of postmolar trophoblastic disease after partial molar pregnancy Gynecol Oncol 48 2 1993 165 170
5. E.I. Kohorn The new FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease: description and critical assessment Int J Gynecol Cancer 11 1 2001 73 77
6. M. Alazzam, J. Tidy, B.W. Hancock, and R. Osborne First line chemotherapy in low risk gestational trophoblastic neoplasia Cochrane Database Syst Rev 1 Jan 21 2009 CD007102
7. R.A. Abrão, J.M. de Andrade, D.G. Tiezzi, H.R. Marana, Candido dos Reis FJ, and W.S. Clagnan Treatment of low-risk gestational trophoblastic disease: comparison of single-agent methotrexate, dactinomycin and combination regimens Gynecol Oncol 108 1 2008 149 153
8. M.M. Gilani, F. Yarandi, Z. Eftekhar, and P. Hanjani Comparison of pulse methotrexate and pulse dactinomycin in the treatment of low-risk gestational trophoblastic neoplasia Aust N Z J Obstet Gynaecol 45 2 2005 161 164
9. A.A. Lertkhachonsuk, N. Israngura, S. Wilailak, and S. Tangtrakul Actinomycin d versus methotrexate-folinic acid as the treatment of stage I, low-risk gestational trophoblastic neoplasia: a randomized controlled trial Int J Gynecol Cancer 19 5 2009 985 988
10. E.B. Smith, J.C. Weed Jr., L. Tyrey, and C.B. Hammond Treatment of nonmetastatic gestational trophoblastic disease: results of methotrexate alone versus methotrexate-folinic acid Am J Obstet Gynecol 144 1 1982 88 92
11. L.C. Wong, Y.C. Choo, and H.K. Ma Methotrexate and citrovorum factor rescue in gestational trophoblastic disease Am J Obstet Gynecol 152 1 1985 59 62
12. F. Yarandi, A. Eftekhar, H. Shojaei, S. Kanani, A. Sharifi, and P. Hanjani Pulse methotrexate versus pulse actinomycin D in the treatment of low-risk gestational trophoblastic neoplasia Int J Gynaecol Obstet 103 1 2008 33 37
13. E.I. Kohorn Decision making for chemotherapy administration in patients with low risk gestational trophoblastic neoplasia Int J Gynecol Cancer 6 4 1996 279 285
14. R.J. Osborne, V. Filiaci, and J.C. Schink Phase III trial of weekly methotrexate or pulsed dactinomycin for low-risk gestational trophoblastic neoplasia: a gynecologic oncology group study J Clin Oncol 29 7 2011 825 831
15. J.P. Smith Chemotherapy in gynecologic cancer Clin Obstet Gynecol 18 4 1975 109 124
16. P.G. Rose, and M.S. Piver Alternating methotrexate and dactinomycin in nonmetastatic gestational trophoblastic disease J Surg Oncol 41 3 1989 148 152