The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID)

Clinical Rheumatology

Volumn 31, Issue 2, 2012, Pages 317-323

  Park, Kyung Su ^a   Choi, Jin Jung ^b   Kim, Wan Uk ^c   Min, June Ki ^d   Park, Sung Hwan ^a   Cho, Chul Soo ^e  

^a The Catholic University of Korea   (South Korea)

^b CHA University   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d The Catholic University of Korea   (South Korea)

^e The Catholic University of Korea   (South Korea)

Author keywords

Acetaminophen; Nonsteroidal anti inflammatory drug; Osteoarthritis; Pain; Tramadol

Indexed keywords

ACECLOFENAC; MELOXICAM; PARACETAMOL; PARACETAMOL PLUS TRAMADOL;

ADD ON THERAPY; ADULT; AGED; ANALGESIA; ARTICLE; CANADA; CONSTIPATION; CONTROLLED STUDY; DISEASE SEVERITY; DIZZINESS; DRUG EFFICACY; FEMALE; HEARTBURN; HUMAN; KNEE OSTEOARTHRITIS; KNEE PAIN; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; NAUSEA; PRIORITY JOURNAL; RANDOMIZATION; RATING SCALE;

ACETAMINOPHEN; AGED; ANALGESICS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG COMBINATIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; TRAMADOL; TREATMENT OUTCOME;

EID: 84856707656     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-011-1818-y     Document Type: Article

References (28)

1. P Creamer MC Hochberg 1997 Osteoarthritis Lancet 350 503 508 9274595 10.1016/S0140-6736(97)07226-7 1:STN:280:DyaK2svitVSruw%3D%3D (Pubitemid 27343314)
2. DT Felson Y Zhang 1998 An update on the epidemiology of knee and hip osteoarthritis with a view to prevention Arthritis Rheum 41 1343 1355 9704632 10.1002/1529-0131(199808)41:8<1343::AID-ART3>3.0.CO;2-9 1:STN:280:DyaK1czmvVegsg%3D%3D (Pubitemid 28373113)
3. RC Lawrence DT Felson CG Helmick LM Arnold H Choi RA Deyo, et al. 2008 Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II Arthritis Rheum 58 26 35 18163497 10.1002/art.23176
4. MA Davis WH Ettinger JM Neuhaus KP Mallon 1991 Knee osteoarthritis and physical functioning: evidence from the NHANES I Epidemiologic Followup Study J Rheumatol 18 591 598 2066950 1:STN:280:DyaK3M3psFWitg%3D%3D
5. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines 2000 Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update Arthritis Rheum 43 1905 1915 10.1002/1529- 0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-P
6. K Jordan N Arden M Doherty B Bannworth JW Bijlsma P Dieppe, et al. 2003 EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis Ann Rheum Dis 62 1145 1155 14644851 10.1136/ard.2003.011742 1:STN:280:DC%2BD3srpsFGmug%3D%3D (Pubitemid 37500619)
7. W Zhang A Jones M Doherty 2004 Does paracetamol (acetaminophen) reduce the pain of osteoarthritis?: a meta-analysis of randomized controlled trials Ann Rheum Dis 63 901 907 15020311 10.1136/ard.2003.018531 1:CAS:528: DC%2BD2cXntVansrc%3D (Pubitemid 38961912)
8. SH Roth 1998 Efficacy and safety of tramadol HCL in breakthrough musculoskeletal pain attributed to osteoarthritis J Rheumatol 25 1358 1363 9676769 1:CAS:528:DyaK1cXkslWjsL0%3D (Pubitemid 28312355)
9. RA Medve J Wang R Karim 2001 Tramadol and acetaminophen tablets for dental pain AnesthProg 48 79 81 1:STN:280:DC%2BD3MnnvVGgsg%3D%3D
10. JR Fricke Jr DJ Hewitt DM Jordan A Fisher NR Rosenthal 2004 A double-blind placebo-controlled comparison of tramadol/acetaminophen and tramadol in patients with postoperative dental pain Pain 109 250 257 15157685 10.1016/j.pain.2004.01.004 1:CAS:528:DC%2BD2cXkt1Slt7o%3D (Pubitemid 38638701)
11. PM Peloso L Fortin A Beaulieu M Kamin N Rosenthal Protocol TRP-CAN-1 Study Group 2004 Analgesic efficacy and safety of tramadol/acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial J Rheumatol 31 2454 2456 15570651 1:CAS:528:DC%2BD2MXivFKqsw%3D%3D
12. SD Silberstein FG Freitag TD Rozen DB Kudrow DJ Hewitt DM Jordan, et al. 2005 Tramadol/acetaminophen for the treatment of acute migraine pain: findings of a randomized, placebo-controlled trial Headache 45 1317 1327 16324164 10.1111/j.1526-4610.2005.00264.x (Pubitemid 350004945)
13. RM Bennett J Schein MR Kosinski DM Hewitt DM Jordan NR Rosenthal 2005 Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen Arthritis Rheum 53 519 527 16082646 10.1002/art.21319 (Pubitemid 41278916)
14. R Emkey N Rosenthal SC Wu D Jordan M Kamin CAPSS-114 Study Group 2004 Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal anti-inflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial J Rheumatol 31 150 156 14705234 1:CAS:528: DC%2BD2cXht1Snurw%3D (Pubitemid 38067537)
15. NR Rosenthal JC Silverfield SC Wu D Jordan M Kamin CAPSS-105 Study Group 2004 Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population J Am GeriatrSoc 52 374 380 10.1111/j.1532-5415.2004.52108.x (Pubitemid 38339517)
16. CB Choi JS Song YM Kang CH Suh J Lee JY Choe, et al. 2007 A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis pain ClinTher 29 1381 1389 1:CAS:528:DC%2BD2sXhtVemurjP (Pubitemid 47348113)
17. JC Silberfield M Kamin SC Wu N Rosenthal CAPSS-105 Study Group 2002 Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study ClinTher 24 282 297 (Pubitemid 34208422)
18. WA Katz 2002 Use of nonopioid analgesics and adjunctive agents in the management of pain in rheumatic diseases Curr Opin Rheumatol 14 63 71 11790999 10.1097/00002281-200201000-00012 1:CAS:528:DC%2BD38XmvVKrug%3D%3D (Pubitemid 34059892)
19. R Altman E Asch D Bloch G Bole D Borenstein K Brandt, et al. 1986 Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association Arthritis Rheum 29 1039 1049 3741515 10.1002/art.1780290816 1:STN:280:DyaL283psF2msQ%3D%3D
20. SC Bae HS Lee HR Yun TH Kim DH Yoo SY Kim 2001 Cross-cultural adaptation and validation of Korean Western Ontario and McMaster Universities (WOMAC) and Lequesne osteoarthritis indices for clinical research Osteoarthr Cartil 9 746 750 11795994 10.1053/joca.2001.0471 1:STN:280:DC%2BD38%2FmvVylug%3D%3D (Pubitemid 33076766)
21. GJ Hathway D Vega-Avelaira A Moss R Ingram M Fitzgerald 2009 Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates Pain 144 110 118 19410369 10.1016/j.pain.2009.03.022
22. SE Gwilym JR Keltner CE Warnaby AJ Carr B Chizh I Chessell, et al. 2009 Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients Arthritis Rheum 61 1226 1234 19714588 10.1002/art.24837
23. T Neogi J Niu L Arendt-Nielsen J Scholz L Frey-Law C Woolf, et al. 2010 Central sensitization and knee pain in osteoarthritis: preliminary results from the MOST study Arthritis Rheum 62 Suppl. 10 2098
24. S Ide M Minami K Ishihara GR Uhl I Sora K Ikeda 2006 Mu opioid receptor-dependent and independent components in effects of tramadol Neuropharmacology 51 651 658 16793069 10.1016/j.neuropharm.2006.05.008 1:CAS:528:DC%2BD28XotlOjtLg%3D (Pubitemid 44215970)
25. M Barann B Urban U Stamer Z Dorner H Bonisch M Bruss 2006 Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis Eur J Pharmacol 531 54 58 16427041 10.1016/j.ejphar.2005.11.054 1:CAS:528: DC%2BD28XhtlejurY%3D (Pubitemid 43202215)
26. DM Halfpenny LF Callado SE Hopwood TA Bamigbade RM Langford JA Stamford 1999 Effects of tramadol stereroisomers on norepinephrine efflux and uptake in the rat locus coeruleus measured by real time voltammetry Br J Anaesth 83 909 915 10700792 1:CAS:528:DC%2BD3cXls1Kmug%3D%3D
27. JA Desmeules C Cedraschi E Rapiti E Baumgartner A Finckh P Cohen, et al. 2003 Neurophysiologic evidence for a central sensitization in patients with fibromyalgia Arthritis Rheum 48 1420 1429 12746916 10.1002/art.10893 1:STN:280:DC%2BD3s3itlKnsA%3D%3D (Pubitemid 36554542)
28. M Meeus J Nijs 2007 Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome ClinRheumatol 26 465 473 (Pubitemid 46359284)