Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: The critical role of ASK1 and VEGF

Hypertension Research

Volumn 35, Issue 2, 2012, Pages 194-200

  Nako, Hisato ^a   Kataoka, Keiichiro ^a   Koibuchi, Nobutaka ^a   Dong, Yi Fei ^a   Toyama, Kensuke ^a   Yamamoto, Eiichiro ^b   Yasuda, Osamu ^b   Ichijo, Hidenori ^c   Ogawa, Hisao ^a   Kim Mitsuyama, Shokei ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

ASK1; endothelial apoptosis; heart failure; oxidative stress; VEGF

Indexed keywords

ANGIOTENSIN II; APOPTOSIS SIGNAL REGULATING KINASE 1; HYDRALAZINE; IRBESARTAN; TEMPOL; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAPILLARY DENSITY; CAPILLARY ENDOTHELIUM; CELL CULTURE; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; DISEASE COURSE; ENDOTHELIUM CELL; HEART FAILURE; HEART HYPERTROPHY; HEART INJURY; HEART MUSCLE CAPILLARY; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HYPERTENSION; MALE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PROTEIN EXPRESSION; RAT;

ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; APOPTOSIS; BIPHENYL COMPOUNDS; BLOOD PRESSURE; BLOTTING, WESTERN; CAPILLARIES; CELLS, CULTURED; CYCLIC N-OXIDES; ENDOTHELIAL CELLS; HEART DISEASES; HYDRALAZINE; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; IMMUNOHISTOCHEMISTRY; MAP KINASE KINASE KINASE 5; MYOCARDIAL ISCHEMIA; OXIDATIVE STRESS; RATS; RATS, INBRED DAHL; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; SPIN LABELS; SUPEROXIDES; TETRAZOLES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84856705908     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2011.175     Document Type: Article

References (21)

1. Kim S, Iwao H. Molecular and cellular mechanisms of angiotensin ii-mediated cardiovascular and renal diseases. Pharmacol Rev 2000; 52: 11-34. (Pubitemid 30127593)
2. Kim S, Yoshiyama M, Izumi Y, Kawano H, Kimoto M, Zhan Y, Iwao H. Effects of combination of ace inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure. Circulation 2001; 103: 148-154. (Pubitemid 32050450)
3. Yamamoto E, Kataoka K, Shintaku H, Yamashita T, Tokutomi Y, Dong YF, Matsuba S, Ichijo H, Ogawa H, Kim-Mitsuyama S. Novel mechanism and role of angiotensin ii induced vascular endothelial injury in hypertensive diastolic heart failure. Arterioscler Thromb Vasc Biol 2007; 27: 2569-2575. (Pubitemid 350158907)
4. Yamamoto E, Kataoka K, Yamashita T, Tokutomi Y, Dong YF, Matsuba S, Ogawa H, Kim-Mitsuyama S. Role of xanthine oxidoreductase in the reversal of diastolic heart failure by candesartan in the salt-sensitive hypertensive rat. Hypertension 2007; 50: 657-662. (Pubitemid 47442728)
5. Mann DL, Bristow MR. Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation 2005; 111: 2837-2849. (Pubitemid 40791557)
6. Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The charm-preserved trial. Lancet 2003; 362: 777-781. (Pubitemid 37093918)
7. Ferrara N. Vascular endothelial growth factor: Basic science and clinical progress. Endocr Rev 2004; 25: 581-611. (Pubitemid 39099316)
8. Hudlicka O, Brown M, Egginton S. Angiogenesis in skeletal and cardiac muscle. Physiol Rev 1992; 72: 369-417.
9. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. P53-induced inhibition of hif-1 causes cardiac dysfunction during pressure overload. Nature 2007; 446: 444-448. (Pubitemid 46474597)
10. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, Colucci WS, Walsh K. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 2005; 115: 2108-2118. (Pubitemid 41134152)
11. Doi R, Masuyama T, Yamamoto K, Doi Y, Mano T, Sakata Y, Ono K, Kuzuya T, Hirota S, Koyama T, Miwa T, Hori M. Development of different phenotypes of hypertensive heart failure: Systolic versus diastolic failure in dahl salt-sensitive rats. J Hypertens 2000; 18: 111-120. (Pubitemid 30093716)
12. Yamamoto E, Yamashita T, Tanaka T, Kataoka K, Tokutomi Y, Lai ZF, Dong YF, Matsuba S, Ogawa H, Kim-Mitsuyama S. Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects. Arterioscler Thromb Vasc Biol 2007; 27: 556-563.
13. Nakamura T, Yamamoto E, Kataoka K, Yamashita T, Tokutomi Y, Dong YF, Matsuba S, Ogawa H, Kim-Mitsuyama S. Beneficial effects of pioglitazone on hypertensive cardiovascular injury are enhanced by combination with candesartan. Hypertension 2008; 51: 296-301. (Pubitemid 351159942)
14. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ask1, a mammalian mapkkk that activates sapk/jnk and p38 signaling pathways. Science 1997; 275: 90-94. (Pubitemid 27020316)
15. Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H. Ask1 is required for sustained activations of jnk/p38 map kinases and apoptosis. EMBO Rep 2001; 2: 222-228. (Pubitemid 32273301)
16. Yamamoto E, Lai ZF, Yamashita T, Tanaka T, Kataoka K, Tokutomi Y, Ito T, Ogawa H, Kim-Mitsuyama S. Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis. J Hypertens 2006; 24: 2057-2069. (Pubitemid 44371273)
17. Izumiya Y, Shiojima I, Sato K, Sawyer DB, Colucci WS, Walsh K. Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. Hypertension 2006; 47: 887-893. (Pubitemid 44297560)
18. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. Circ Res 2000; 87: 840-844.
19. Griendling KK, Sorescu D, Ushio-Fukai M. Nad(p)h oxidase: role in cardiovascular biology and disease. Circ Res 2000; 86: 494-501. (Pubitemid 30165039)
20. Takimoto E, Kass DA. Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension 2007; 49: 241-248. (Pubitemid 46142995)
21. Matsukawa J, Matsuzawa A, Takeda K, Ichijo H. The ask1-map kinase cascades in mammalian stress response. J Biochem 2004; 136: 261-265. (Pubitemid 39545783)