Antiplatelet therapy vs. anticoagulation in cervical artery dissection; Rationale and design of the Cervical Artery Dissection in Stroke Study (CADISS)

International Journal of Stroke

Volumn 2, Issue 4, 2007, Pages 292-296

  Markus, Hugh ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Acute stroke; Carotid artery; Cerebrovascular disorders; Dissection; Randomised control trial; Secondary prevention; Vertebral artery

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; DIPYRIDAMOLE; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; WARFARIN;

ANTICOAGULANT THERAPY; ARTERY DISSECTION; CAROTID ARTERY INJURY; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; HUMAN; INTERNATIONAL NORMALIZED RATIO; MONOTHERAPY; MULTICENTER STUDY; NEUROIMAGING; OPEN STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; STROKE; SYMPTOM; THROMBOEMBOLISM; TRANSIENT ISCHEMIC ATTACK; TREATMENT DURATION;

ANEURYSM, DISSECTING; ANTICOAGULANTS; ASPIRIN; CLINICAL PROTOCOLS; DIAGNOSTIC IMAGING; DIPYRIDAMOLE; DRUG THERAPY, COMBINATION; ENDPOINT DETERMINATION; FEASIBILITY STUDIES; GREAT BRITAIN; HEPARIN; HUMANS; MULTICENTER STUDIES AS TOPIC; PATIENT SELECTION; PLATELET AGGREGATION INHIBITORS; PROSPECTIVE STUDIES; QUALITY ASSURANCE, HEALTH CARE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; SAMPLE SIZE; SINGLE-BLIND METHOD; STROKE; TICLOPIDINE; WARFARIN;

EID: 36249031088     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/j.1747-4949.2007.00165.x     Document Type: Conference Paper

References (14)

1. Beletsky V, Nadareishvili Z, Lynch J, Shuaib A, Woolfenden A, Norris JW: Canadian stroke consortium. Cervical arterial dissection; time for a therapeutic trial? Stroke 2003; 34: 2856-60.
2. Schievink WI: Spontaneous dissection of the carotid and vertebral arteries. N Engl J Med 2001; 344: 898-906.
3. Biousse V, D'Anglejan-Chatillon J, Touboul PJ, Amarenco P, Bousser MG: Timecourse of symptoms in extracranial carotid artery dissections. A series of 80 patients. Stroke 1995; 26: 235-9.
4. Molina CA, Alvarez-Sabin J, Schonewille W et al. Cerebral microembolism in acute spontaneous internal artery dissection. Neurology 2000; 55: 1738-40.
5. Srinivasan J, Newell DW, Sturzenegger M, Maybert MR, Winn HR: Transcranial Doppler in the evaluation of internal carotid artery dissection. Stroke 1996; 27: 1226-30.
6. Lucas C, Moulin T, Deplanque D, Tatu L, Chavot D, for the Donald Investigators: Stroke patterns of internal carotid artery dissection in 40 patients. Stroke 1998; 29: 2646-8.
7. Stroke Prevention in Reversible Ischemia Trial (SPIRIT) Study Group: A randomized trial of anticoagulant versus aspirin after cerebral ischemia of presumed arterial origin. Ann Neurol 1997; 42: 857-65.
8. Mohr JP, Thompson JL, Lazar RM et al. Warfarin-aspirin recurrent stroke study group. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med 2001; 345: 1444-51.
9. The ESPRIT Study Group, Algra A.: Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): A randomised controlled trial. Lancet Neurol 2007; 6: 115-24.
10. Lyrer P, Engelter S: Antithrombotic Drugs for Carotid Artery Dissection. Cochrane Review. Oxford, UK: Cochrane Library, 2002.
11. Schulman S, Kearon C on behalf of the Subcommittee on Control of Anticoagulation of the scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis: Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemostasis 2005; 3: 592-694.
12. Medical Research Council: MRC Guidelines for Good Clinical Practice in Clinical Trials. London: Medical Research Council, 1998.
13. Markus HS, Droste DW, Kaps M et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using Doppler embolic signal detection: The Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial. Circulation 2005; 111: 2233-40.
14. Ringelstein EB, Droste DW, Babikian VL et al. Consensus on microembolus detection by TCD. International consensus group on microembolus detection. Stroke 1998; 29: 725-9.