Contribution of celiac disease autoantibodies to the disease process

Expert Review of Clinical Immunology

Volumn 8, Issue 2, 2012, Pages 151-154

  Lindfors, Katri ^a   Kaukinen, Katri ^a,b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

adhesion; autoantibody; celiac disease; epithelium

Indexed keywords

AUTOANTIBODY; ENZYME ANTIBODY; HEPARIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; TRANSGLUTAMINASE 2 ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; CELIAC DISEASE; CELL ADHESION; CELL STRAIN CACO 2; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; INTESTINE EPITHELIUM CELL; REVIEW;

EID: 84856610721     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/eci.11.89     Document Type: Review

References (20)

1. Lindfors K, Mäki M, Kaukinen K. Transglutaminase 2-targeted autoantibodies in celiac disease: pathogenetic players in addition to diagnostic tools? Autoimmun. Rev. 9(11), 744-749 (2010).
2. Korponay-Szabó IR, Sulkanen S, Halttunen T, et al. Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies. J. Pediatr. Gastroenterol. Nut. 31(5), 520-527 (2000).
3. Belkin AM. Extracellular TG2: emerging functions and regulation. FEBS J. 278(24), 4704-4716 (2011).
4. Akimov SS, Krylov D, Fleischman LF, Belkin AM. Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J. Cell Biol. 148(4), 825-838 (2000).
5. Telci D, Wang Z, Li X, et al. Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and b1 integrin co-signaling. J. Biol. Chem. 283(30), 20937-20947 (2008).
6. Koskinen O, Collin P, Lindfors K, Laurila K, Mäki M, Kaukinen K. Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease. J. Clin. Gastroenterol. 44(7), 483-488 (2010).
7. Teesalu K, Panarina M, Uibo O, Uibo R, Utt M. Autoantibodies from patients with celiac disease inhibit transglutaminase 2 binding to heparin/heparan sulfate and interfere with intestinal epithelial cell adhesion. Amino Acids doi:10.1007/s00726-011-1020-1021-1 (2011) (Epub ahead of print).
8. Myrsky E, Kaukinen K, Syrjänen M, Korponay-Szabó IR, Mäki M, Lindfors K. Coeliac disease-specific autoantibodies targeted against transglutaminase 2 disturb angiogenesis. Clin. Exp. Immunol. 152(1), 111-119 (2008). (Pubitemid 351347552)
9. Myrsky E, Caja S, Simon-Vecsei Z, et al. Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA. Cell. Mol. Life Sci. 66(20), 3375-3385 (2009).
10. Caputo I, Barone MV, Lepretti M, et al. Celiac anti-tissue transglutaminase antibodies interfere with the uptake of a gliadin peptide 31-43 but not of peptide 57-68 by epithelial cells. Biochim. Biophys. Acta 1802(9), 717-727 (2010).
11. Halttunen T, Mäki M. Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. Gastroenterology 116(3), 566-572 (1999). (Pubitemid 29106764)
12. Barone MV, Caputo I, Ribecco MT, et al. Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease. Gastroenterology 132(4), 1245-1253 (2007). (Pubitemid 46627567)
13. Zanoni G, Navone R, Lunardi C, et al. In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. PLoS Med. 3(9), e358 (2006).
14. Rauhavirta T, Qiao SW, Jiang Z, et al. Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A. Clin. Exp. Immunol. 164(1), 127-136 (2011).
15. Verderio EA, Telci D, Okoye A, Melino G, Griffin M. A novel RGD-independent cell adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis. J. Biol. Chem. 278(43), 42604-42614 (2003). (Pubitemid 37310534)
16. Király R, Vecsei Z, Deményi T, Korponay-Szabó IR, Fésüs L. Coeliac autoantibodies can enhance transamidating and inhibit GTPase activity of tissue transglutaminase: dependence on reaction environment and enzyme fitness. J. Autoimmun. 26(4), 278-287 (2006). (Pubitemid 43817486)
17. Caja S, Myrsky E, Korponay-Szabo IR, et al. Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies. Scand. J. Gastroenterol. 45(4), 421-427 (2010).
18. Esposito C, Paparo F, Caputo I, et al. Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Gut 51(2), 177-181 (2002). (Pubitemid 34791442)
19. Dieterich W, Trapp D, Esslinger B, et al. Autoantibodies of patients with coeliac disease are insufficient to block tissue transglutaminase activity. Gut 52(11), 1562-1566 (2003). (Pubitemid 37363438)
20. Kainulainen H, Rantala I, Collin P, et al. Blisters in small intestinal mucosa of coeliac patients contain T cells positive for cyclooxygenase-2. Gut 50(1), 81-89 (2002).