Antioxidant supplements in exercise: Worse than useless?

American Journal of Physiology - Endocrinology and Metabolism

Volumn 302, Issue 4, 2012, Pages

  Gomez Cabrera, Mari Carmen ^a   Ristow, Michael ^b   Viña, Jose ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; GLUCOSE TRANSPORTER 4; INSULIN; MESSENGER RNA; THIOCTIC ACID; XANTHINE OXIDASE;

ADAPTATION; AEROBIC EXERCISE; BIOGENESIS; BLOOD PRESSURE; CARDIOVASCULAR RISK; DIABETES MELLITUS; ENDURANCE; ENZYME INHIBITION; EXERCISE; HEART FAILURE; HUMAN; HYPERTENSION; INSULIN SENSITIVITY; LETTER; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SKELETAL MUSCLE; TASK PERFORMANCE; VASCULAR DISEASE; VASODILATATION; VITAMIN SUPPLEMENTATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIOXIDANTS; CYTOPROTECTION; MALE; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL;

EID: 84856601404     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00567.2011     Document Type: Letter

References (20)

1. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297: 842-857, 2007.
2. Close GL, Ashton T, Cable T, Doran D, Holloway C, McArdle F, MacLaren DP. Ascorbic acid supplementation does not attenuate postexercise muscle soreness following muscle-damaging exercise but may delay the recovery process. Br J Nutr 95: 976-981, 2006.
3. Gey GO, Cooper KH, Bottenberg RA. Effect of ascorbic acid on endurance performance and athletic injury. JAMA 211: 105, 1970.
4. Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Vina J. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 87: 142-149, 2008.
5. Higashida K, Kim SH, Higuchi M, Holloszy JO, Han DH. Normal adaptations to exercise despite protection against oxidative stress. Am J Physiol Endocrinol Metab 301: E779-E784, 2011.
6. Kang C, O'Moore KM, Dickman JR, Ji LL. Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling is redox sensitive. Free Radic Biol Med 47: 1394-1400, 2009.
7. Keren G, Epstein Y. The effect of high dosage vitamin C intake on aerobic and anaerobic capacity. J Sports Med Phys Fitness 20: 145-148, 1980.
8. Khassaf M, McArdle A, Esanu C, Vasilaki A, McArdle F, Griffiths RD, Brodie DA, Jackson MJ. Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle. J Physiol 549: 645-652, 2003.
9. Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, Ross C, Arnold A, Sleight P, Probstfield J, Dagenais GR. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 293: 1338-1347, 2005.
10. Malm C, Svensson M, Ekblom B, Sjodin B. Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans. Acta Physiol Scand 161: 379-384, 1997.
11. Malm C, Svensson M, Sjoberg B, Ekblom B, Sjodin B. Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiol Scand 157: 511-512, 1996.
12. Marshall RJ, Scott KC, Hill RC, Lewis DD, Sundstrom D, Jones GL, Harper J. Supplemental vitamin C appears to slow racing greyhounds. J Nutr 132: 1616S-1621S, 2002.
13. Maughan RJ. Nutritional ergogenic aids and exercise performance. Nutr Res Rev 12: 255-280, 1999.
14. Ristow M, Zarse K, Oberbach A, Kloting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Bluher M. Antioxidants prevent healthpromoting effects of physical exercise in humans. Proc Natl Acad Sci USA 106: 8665-8670, 2009.
15. Sharman IM, Down MG, Sen RN. The effects of vitamin E and training on physiological function and athletic performance in adolescent swimmers. Br J Nutr 26: 265-276, 1971.
16. Sobal J, Marquart LF. Vitamin/mineral supplement use among athletes: a review of the literature. Int J Sport Nutr 4: 320-334, 1994.
17. Strobel NA, Peake JM, Matsumoto A, Marsh SA, Coombes JS, Wadley GD. Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis. Med Sci Sports Exerc 43: 1017-1024.
18. Theodorou AA, Nikolaidis MG, Paschalis V, Koutsias S, Panayiotou G, Fatouros IG, Koutedakis Y, Jamurtas AZ. No effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training. Am J Clin Nutr 93: 1373-1383.
19. Wray DW, Uberoi A, Lawrenson L, Bailey DM, Richardson RS. Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome. Clin Sci (Lond) 116: 433-441, 2009.
20. Yfanti C, Akerstrom T, Nielsen S, Nielsen AR, Mounier R, Mortensen OH, Lykkesfeldt J, Rose AJ, Fischer CP, Pedersen BK. Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc 42: 1388-1395, 2010.