The SHR Y chromosome increases cardiovascular, endocrine, and behavioral responses to stress compared to the WKY Y chromosome

Physiology and Behavior

Volumn 106, Issue 2, 2012, Pages 101-108

  Dickey, Cherec ^a   Toot, Jonathan ^a   Terwilliger, Melissa ^a   Payne, Rex ^a   Turner, Monte ^a   Ely, Daniel ^a  

^a UNIVERSITY OF AKRON   (United States)

Author keywords

Corticosterone; Exercise; Locomotor activity; Norepinephrine; Open field; Sry; Telemetry

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; NORADRENALIN; TESTIS DETERMINING FACTOR;

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; GROOMING; HEART RATE; HIPPOCAMPUS; HORMONE RESPONSE; HYPERTENSION; IMMOBILIZATION; IMMOBILIZATION STRESS; LOCOMOTION; MALE; NONHUMAN; NORADRENALIN BLOOD LEVEL; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REARING; RUNNING; SPONTANEOUSLY HYPERTENSIVE RAT; STRAIN DIFFERENCE; STRESS; SYSTOLIC BLOOD PRESSURE; VOLUNTARY MOVEMENT; WISTAR KYOTO RAT; Y CHROMOSOME;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BLOOD PRESSURE; BRAIN; CORTICOSTERONE; HEART RATE; MALE; MOTOR ACTIVITY; NOREPINEPHRINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RESTRAINT, PHYSICAL; SEX-DETERMINING REGION Y PROTEIN; SPECIES SPECIFICITY; STRESS, PHYSIOLOGICAL; Y CHROMOSOME;

EID: 84856600315     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2012.01.009     Document Type: Article

References (54)

1. Berton O., Ramos A., Chaouloff F., Mormede P. Behavioral reactivity to social and nonsocial stimulations: a multivariate analysis of six inbred rat strains. Behav Genet 1997, 27:155-166.
2. Caplea A., Seachrist D., Dunphy G., Ely D. SHR Y chromosome enhances the nocturnal blood pressure in socially interacting rats. Am J Physiol Heart Circ Physiol 2000, 279:H58-H66.
3. Delini-Stula A., Hunn C. Neophobia in spontaneous hypertensive (SHR) and normotensive control (WKY) rats. Behav Neural Biol 1985, 43:206-211.
4. Dewing P., Chiang C.W.K., Sinchak K., Sim H., Fernagut P.-O., Kelly S., et al. Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol 2006, 16:415-420.
5. Ely D., Boehme S., Dunphy G., Hart M., Chiarappa F., Miller B., et al. The Sry3 Y chromosome locus elevates blood pressure and renin-angiotensin system indices. Gend Med 2011, 8:126-138.
6. Ely D., Caplea A., Dunphy G., Daneshvar H., Turner M., Milsted A., et al. Spontaneously hypertensive rat Y chromosome increases indexes of sympathetic nervous system activity. Hypertension 1997, 29:613-618.
7. Ely Daniel L., Falvo Jessica, Dunphy Gail, Caplea Ann, Salisbury Ron, Turner Monte The spontaneously hypertensive rat Y chromosome produces an early testosterone rise in normotensive rats. J Hypertens 1994, 12:769-774.
8. Ely D., Friberg P., Nilsson H., Folkow B. Blood pressure and heart rate responses to mental stress in spontaneously hypertensive (SHR) and normotensive (WKY) rats on various sodium diets. Acta Physiol Scand 1985, 123:159-169.
9. Ely D.L., Greene E., Henry J.P. The effects of hippocampal lesion on cardiovascular, adrenocortical and behavioral response patterns in mice. Physiol Behav 1977, 18:1075-1083.
10. Ely D., Milsted A., Bertram J., Ciotti M., Dunphy G., Turner M. Sry delivery to the adrenal medulla increases blood pressure and adrenal medullary tyrosine hydroxylase of normotensive WKY rats. BMC Cardiovasc Disord 2007, 7:6.
11. Ely D., Milsted A., Dunphy G., Boehme S., Dunmire J., Hart M., et al. Delivery of Sry1, but not Sry2, to the kidney increases blood pressure and SNS indices in normotensive WKY rats. BMC Physiol 2009, 9:10.
12. Ely D., Toot J., Salisbury, Ramirez R. Androgens alter brain catecholamine content and blood pressure in the testicular feminized male rat. Clin Exp Hypertens 2011, 1-9. Early online. 10.3109/10641963.2010.531840.
13. Ely D., Turner M. Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome. Hypertension 1990, 16:277-281.
14. Ely D., Underwood A., Dunphy G., Boehme S., Turner M., Milsted A. Review of the Y chromosome, Sry and hypertension. Steroids 2008, 75:747-753.
15. Ferguson S., Cada A. A longitudinal study of short- and long-term activity levels in male and female spontaneously hypertensive, Wistar-Kyoto, and Sprague-Dawley rats. Behav Neurosci 2003, 117:271-282.
16. Folkow B., Hallback-Norlander M., Martner J., Nordborg C. Influence of amygdala lesions on cardiovascular responses to alerting stimuli, on behaviour and on blood pressure development in spontaneously hypertensive rats. Acta Physiol Scand 1982, 116:133-139.
17. Gaudet E., Blanc J., Elghozi J. Role of angiotensin II and catecholamines in blood pressure variability responses to stress in SHR. Am J Physiol Regul Integr Comp Physiol 1996, 270:R1265-R1272.
18. Hard E., Carlsson S., Jern S., Larsson K., Lindh A., Svensson L. Behavioral reactivity in spontaneously hypertensive rats. Physiol Behav 1985, 35:487-492.
19. Hendley E.D., Wessel D.J., van Houten J. Inbreeding of Wistar-Kyoto rat strain with hyperactivity but without hypertension. Behav Neural Biol 1986, 45:1-16.
20. Hoffman P., Thoren P., Ely D. Effect of voluntary exercise on open-field behavior and on aggression in the SHR. Behav Neural Biol 1987, 47:346-355.
21. Kelberman D., Dattani M.T. Hypopituitarism oddities: congenital causes. Horm Res 2007, 68(suppl 5):138-144.
22. Knardahl S. Behavioral responsiveness and habituation to discrete auditory and olfactory stimuli in spontaneously hypertensive, two-kidney one-clip hypertensive, and normotensive rats. Behav Neural Biol 1982, 36:266-279.
23. Knardahl S., Hendley E.D. Association between cardiovascular reactivity to stress and hypertension or behavior. Am J Physiol 1990, 259:H248-H257.
24. Knardahl S., Sagvolden T. Open-field behavior of the spontaneously hypertensive rat. Behav Neural Biol 1979, 27:187-200.
25. Krauchi K., Wirz-Justice A., Willener R., Campbell I., Feer H. Spontaneous hypertensive rats: behavioral and corticosterone response depend on circadian phase. Physiol Behav 1983, 30:35-40.
26. Lahr G., Maxson S.C., Mayer A., Just W., Pilgrim C., Reisert I. Transcription of the Y chromosomal gene, Sry, in adult mouse brain. Brain Res Mol Brain Res 1995, 33:179-182.
27. Liu B., Ely D. Testosterone increases: sodium reabsorption, blood pressure and renal pathology in female spontaneously hypertensive rats on a high sodium diet. Adv Pharmacol Sci 2011, 8. Article ID 817835. 10.1155/2011/817835.
28. Mayer A., Lahr G., Swaab D.F., Pilgrim C., Reisert I. The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain. Neurogenetics 1998, 1:281-288.
29. McGinnis M.Y., Lumia A.R., Tetel M.J., Molenda-Figueira, Possidente B. Effects of anabolic androgenic steroids on the development and expression of running wheel activity and circadian rhythms in male rats. Physiol Behav 2007, 92:1010-1018.
30. Milsted A., Serova L., Sabban E.L., Dunphy G., Turner M.E., Ely D.L. Regulation of tyrosine hydroxylase gene transcription by Sry. Neurosci Lett 2004, 369:203-207.
31. Myers M.M., Musty R.E., Hendley E.D. Attenuation of hyperactivity in the spontaneously hypertensive rat by amphetamine. Behav Neural Biol 1982, 34:42-54.
32. Nelson D.O., Boulant J.A. Altered CNS neuroanatomical organization of spontaneously hypertensive (SHR) rats. Brain Res 1981, 226:119-130.
33. Palkovits M. Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res 1973, 39:449-450.
34. Pernasetti F., Toledo S.P.A., Vasilyev V.V., Hayashida C.Y., Cogan J.D., Ferrari C., et al. Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of pit-1 gene. J Clin Endocrinol Metab 2000, 85:390-397.
35. Ramkissoon Y., Goodfellow P. Early steps in mammalian sex determination. Curr Opin Genet Dev 1996, 6:316-321.
36. Ramos A., Berton O., Mormede P., Chaouloff F. A multiple test study of anxiety-related behaviours in six inbred rat strains. Behav Brain Res 1997, 85:57-69.
37. Stotz-Potter E.H., Willis L.R., DiMicco J.A. Muscimol acts in dorsomedial but not paraventricular hypothalamic nucleus to suppress cardiovascular effects of stress. J Neurosci 1996, 16:1173-1179.
38. Sutterer J.R., Stoney C.M., Sanfillipo M. Is the hypertensive rat really hypertensive?. Hypertension 1984, 6:868-876.
39. Toot J., Jenkins C., Dunphy G., Boehme S., Hart M., Milsted A., et al. Testosterone influences renal electrolyte excretion in SHR/y and WKY males. BMC Physiol 2008, 8:5. 10.1186/1472-6793-8-5.
40. Toot J., Reho J.J., Novak J., Dunphy G., Ely D.L., Ramirez R.J. Colony social stress differentially alters blood pressure and resistance-sized mesenteric artery reactivity in SHR/y and WKY male rats. Stress 2011, 14:33-41.
41. Toot J.D., Reho J.J., Ramirez R.J., Novak J., Ely D.L. Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation. Biol Sex Differ 2012, 3(1):1. Jan 3, [Epub ahead of print].
42. Toot J.D., Reho J.J., Novak J., Dunphy G., Ely D.L., Ramirez R.J. Testosterone increases myogenic reactivity of second-order mesenteric arteries in both defective and normal androgen receptor adult male rats. Gend Med 2011, 8:40-52.
43. Turner M.E., Ely D., Prokop J., Milsted A. Sry, more than testis determination?. Am J Physiol Regul Integr Comp Physiol 2011, 301:R561-R571.
44. Turner M.E., Farkas J., Dunmire J., Ely D., Milsted A. Which Sry locus is the hypertensive Y chromosome locus?. Hypertension 2009, 53:430-435.
45. Turner M.E., Johnson M.L., Ely D.L. Separate sex-influenced and genetic components in spontaneously hypertensive rat hypertension. Hypertension 1991, 17:1097-1103.
46. Turner M.E., Martin C., Martins A.S., Dunmire J., Farkas J., Ely D.L., et al. Genomic and expression analysis of multiple Sry loci from a single Rattus norvegicus Y chromosome. BMC Genet 2007, 8:11.
47. Van den Buuse M. Cardiovascular and behavioural responses to psychological stress in spontaneously hypertensive rats: effect of treatment with DSP-4. Behav Brain Res 2001, 119:131-142.
48. Van den Buuse M., de Jong W. Differential effects of dopaminergic drugs on open-field behavior of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. J Pharmacol Exp Ther 1989, 248:1189-1196.
49. Van den Buuse M., Van Acker S.A.B.F., Fluttert M., DeKloet E.R. Blood pressure, heart rate, and behavioral responses to psychological novelty stress in freely moving rats. Psychophysiology 2001, 38:490-499.
50. 1A receptors in cardiovascular responses to stress: a radio-telemetry study in four rat strains. Eur J Pharmacol 2005, 507:87-198.
51. Wiley D., Dunphy G., Daneshvar H., Salisbury R., Neeki M., Ely D. Neonatal sympathectomy reduces adult blood pressure and cardiovascular pathology in Y chromosome consomic rats. Blood Press 1999, 8:300-307.
52. Wu J.B., Chen K., Li Y., Lau Y-F C., Shih J.C. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J 2009, 23:4029-4038.
53. Zhang K., Rao F., Wang L., Rana B.K., Ghosh S., Mahata M., et al. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension. J Am Coll Cardiol 2010, 55:1463-1475.
54. Zhang K., Zhang L., Rao F., Brar B., Rodriguez-Flores J.L., Taupenot L., et al. Human tyrosine hydroxylase natural genetic variation/clinical perspective: delineation of functional transcriptional control motifs disrupted in the proximal promoter. Circ Gen 2010, 3:187-198.