Structural characterisation, stability and antibody recognition of chimeric NHBA-GNA1030: An investigational vaccine component against Neisseria meningitidis

Vaccine

Volumn 30, Issue 7, 2012, Pages 1330-1342

  Martino, Angela ^a,b   Magagnoli, Claudia ^c   De Conciliis, Giuseppe ^c   D'Ascenzi, Sandro ^c   Forster, Mark J ^d   Allen, Lauren ^e   Brookes, Charlotte ^e   Taylor, Stephen ^e   Bai, Xilian ^e   Findlow, Jamie ^e   Feavers, Ian M ^b   Rodger, Alison ^a   Bolgiano, Barbara ^b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^c NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^d JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^e PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Circular dichroism; Equilibrium unfolding; Fusion protein; Heparin binding antigen; Neisseria meningitidis

Indexed keywords

BACTERIAL VACCINE; IMMUNOGLOBULIN G; NEISSERIAL HEPARIN BINDING ANTIGEN FUSION PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL EXPERIMENT; ARTICLE; BETA SHEET; CIRCULAR DICHROISM; DRUG FORMULATION; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE SPECTROSCOPY; IMMUNOGENICITY; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; THERMOSTABILITY;

ADHESINS, BACTERIAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; CIRCULAR DICHROISM; HEPARIN; HOT TEMPERATURE; IMMUNOGLOBULIN G; MENINGOCOCCAL VACCINES; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; NEISSERIA MENINGITIDIS, SEROGROUP B; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84856562684     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.12.066     Document Type: Article

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