Three novel single-nucleotide polymorphisms of complement component 4 gene (C4A) in Chinese Holstein cattle and their associations with milk performance traits and CH50

Veterinary Immunology and Immunopathology

Volumn 145, Issue 1-2, 2012, Pages 223-232

  Yang, Yue ^a,b   Li, Qiuling ^a   Ju, Zhihua ^a   Huang, Jinming ^a   Zhou, Lei ^a   Li, Rongling ^a   Li, Jianbin ^a   Shi, Fangxiong ^b   Zhong, Jifeng ^a   Wang, Changfa ^a  

^a SHANDONG PEANUT RESEARCH INSTITUTE   (China)

^b NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

Bovine; C4 serum level; C4A gene; CH50; Mastitis; SNP

Indexed keywords

COMPLEMENT COMPONENT C4; DNA; METHIONINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; CHINESE; COMPLEMENT BLOOD LEVEL; COMPLEMENT CLASSICAL PATHWAY; CONTROLLED STUDY; COW; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXON; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HEMOLYSIS; HOMOZYGOSITY; MASTITIS; MILK PRODUCTION; NONHUMAN; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; CATTLE; COMPLEMENT C4; COMPLEMENT C4A; COMPLEMENT HEMOLYTIC ACTIVITY ASSAY; DISEASE RESISTANCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HOMOZYGOTE; LACTATION; MASTITIS, BOVINE; MILK; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE;

BACTERIA (MICROORGANISMS); BOS; BOVINAE;

EID: 84856556640     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.11.010     Document Type: Article

References (73)

1. Abe T., Komatsu M., Oishi T., Yamamoto K. Development and genetic differences of complement activity in rabbits. Anim. Blood Groups Biochem. Genet. 1979, 10:19-26.
2. Ali A.K.A., Shook G.E. An optimum transformation for somatic cell concentration in milk. J. Dairy Sci. 1980, 63:487-490.
3. Barrio M.B., Rainard P., Poutrel B. Milk complement and the opsonophagocytosis and killing of Staphylococcus aureus mastitis isolates by bovine neutrophils. Microb. Pathog. 2003, 34:1-9.
4. Bishof N.A., Welch T.R., Beischel L.S. C4B deficiency: a risk factor for bacteremia with encapsulated organisms. J. Infect. Dis. 1990, 162:248-250.
5. Booth N.A., Campbell R.D., Fothergill J.E. The purification and characterization of bovine C4, the fourth component of complement. Biochem. J. 1979, 177:959-965.
6. Botto M., Fong K.Y., So A.K., Koch C., Walport M.J. Molecular basis of polymorphisms of human complement component C3. J. Exp. Med. 1990, 172:1011-1017.
7. Brock J.H., Ortega F., Pineiro A. Bactericidal and haemolytic activity of complement in bovine colostrum and serum: effect of proteolytic enzymes and ethylene glycol tetraacetic acid (EGTA). Ann. Immunol. Inst. Pasteur 1975, 126C:439-451.
8. Brönnestam R. Studies of the C3 polymorphism relationship between C3 phenotypes and rheumatoid arthritis. Hum. Hered. 1973, 23:206-213.
9. Capparelli R., Parlato M., Amoroso M.G., Roperto S., Marabelli R., Roperto F., Iannelli D. Mannose-binding lectin haplotypes influence Brucella abortus infection in the water buffalo (Bubalus bubalis). Immunogenetics 2008, 60:157-165.
10. Duncan D.B. Multiple range and multiple F tests. Biometrics 1955, 11:1-42.
11. Emanuelson U., Danell B., Philipsson J. Genetic parameters for clinical mastitis, somatic cell counts, and milk production estimated by multiple-trait restricted maximum likelihood. J. Dairy Sci. 1988, 71:467-476.
12. Fallin D., Cohen A., Essioux L., Chumakov I., Blumenfeld M., Cohen D., Schork N.J. Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome Res. 2001, 11:143-151.
13. Fjalestad K.T. Possibilities to include disease resistance in the Norwegian breeding programme for salmonids. Proceedings of the Fourth Congress of Genetics Applied to Livestock Production XVI 1990, 461-464.
14. Groth D.M., Lintom-Terry E., Outteridge P., Windon R.G., Wetherall J.D. TaqI RFLP polymorphism of the ovine complement component C4 gene. Nucleic Acids Res. 1990, 18:3102.
15. Guerra-Junior G., Grumach A.S., de Lemos-Marini S.H.V., Kirschfink M., Neto A.C., de Araujo M., Mello M.P.D. Complement 4 phenotypes and genotypes in Brazilian patients with classical 21-hydroxylase deficiency. Clin. Exp. Immunol. 2008, 155:182-188.
16. Günther J., Koczan D., Yang W., Nürnberg G., Repsilber D., Schuberth H.J., Park Z., Maqbool N., Molenaar A., Seyfert H.M. Assessment of the immune capacity of mammary epithelial cells: comparison with mammary tissue after challenge with Escherichia coli. Vet. Res. 2009, 40:31-44.
17. Günther J., Liu S., Esch K., Schuberth H.J., Seyfert H.M. Stimulated expression of TNF-alpha and IL-8, but not of lingual antimicrobial peptide reflects the concentration of pathogens contacting bovine mammary epithelial cells. Vet. Immunol. Immunopathol. 2010, 135:152-157.
18. Hawlisch H., Köhl J. Complement and Toll-like receptors: key regulators of adaptive immune responses. Mol. Immunol. 2006, 43:13-21.
19. Huang J.M., Liu L., Wang H.M., Zhang C.X., Ju Z.H., Wang C.F., Zhong J.F. Variants and gene expression of the TLR2 gene and susceptibility to mastitis in cattle. Asian J. Anim. Vet. Adv. 2011, 6:51-61.
20. Huang J.M., Wang H.M., Wang C.F., Li J.B., Li Q.L., Hou M.H., Zhong J.F. Single nucleotide polymorphism, haplotypes and combined genotypes of lactoferrin gene and their associations with mastitis in Chinese Holstein cattle. Mol. Biol. Rep. 2010, 37:477-483.
21. Kopf M., Abel B., Gallimore A., Carroll M., Bachmann M.F. Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection. Nat. Med. 2002, 8:373-378.
22. Kumar K.G., Ponsuksili S., Schellander K., Wimmers K. Molecular cloning and sequencing of porcine C5 gene and its association with immunological traits. Immunogenetics 2004, 55:811-817.
23. Larsen F., Madsen H.O., Sim R.B., Koch C., Garred P. Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. J. Biol. Chem. 2004, 279:21302-21311.
24. Li Z.M., Zhang S.C., Wang C.F., Pang Q.X. Complement-mediated killing of Vibrio species by the humoral fluids of amphioxus Branchiostoma belcheri: implications for a dual role of O-antigens in the resistance to bactericidal activity. Fish Shellfish Immunol. 2008, 24:215-222.
25. Lillie B.N., Keirstead N.D., Squires E.J., Hayes M.A. Gene polymorphisms associated with reduced hepatic expression of porcine mannan-binding lectin C. Dev. Comp. Immunol. 2007, 31:830-846.
26. Lipscombe R.J., Sumiya M., Summerfield J.A., Turner M.W. Distinct physicochemical characteristics of human mannose binding protein expressed by individuals of differing genotype. Immunology 1995, 85:660-667.
27. Lutz H.U., Jelezarova E. Complement amplification revisited. Mol. Immunol. 2006, 43:2-12.
28. Madsen H.O., Garred P., Thiel S., Kurtzhals J.A., Lamm L.U., Ryder L.P., Svejgaard A. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J. Immunol. 1995, 155:3013-3020.
29. Madsen H.O., Satz M.L., Hogh B., Svejgaard A., Garred P. Different molecular events result in low protein levels of mannan-binding lectin in populations from Southeast Africa and South America. J. Immunol. 1998, 161:3169-3175.
30. Mason C. Basic mastitis bacteriology: untangling the pathogens. Irish Vet. J. 2006, 59:453-459.
31. Miller M.P. Tools for Population Genetic Analyses (TFPGA) 1. 3: A Windows Program for the Analysis of Alloozyme and Molecular Population Genetic Data 1997, http://www.marksgeneticsoftware.net/_vti_bin/shtml.exe/tfpga.htm.
32. Morera A.L., Henry M., García-Hernández A., Fernández-López L. Acute phase proteins as biological markers of negative psychopathology in paranoid schizophrenia. Actas Esp. Psiquiatr. 2007, 35:249-252.
33. Mueller R., Carroll E.J., Panico L. Hemolytic complement titers and complement C3 levels in endotoxin-induced mastitis. Am. J. Vet. Res. 1983, 44:1442-1445.
34. Needs E.C., Anderson M. Lipid composition of milks from cows with experimentally induced mastitis. J. Dairy Res. 1984, 51:239-249.
35. Oswald I.P., Lantier F., Bourgy G. Classical and alternative pathway hemolytic activities of ovine complement: variations with age and sex. Vet. Immunol. Immunopathol. 1990, 24:259-266.
36. Park Y.H., Joo Y.S., Park J.Y., Moon J.S., Kim S.H., Kwon N.H., Ahn J.S., Davis W.C., Davies C.J. Characterization of lymphocyte subpopulations and major histocompatibility complex haplotypes of mastitis-resistant and susceptible cows. J. Vet. Sci. 2004, 5:29-39.
37. Pattanakitsakul S., Zheng J.H., Natsuume-Sakai S., Takahashi M., Nonaka M. Aberrant splicing caused by the insertion of the B2 sequence into an intron of the complement C4 gene is the basis for low C4 production in H-2k mice. J. Biol. Chem. 1992, 267:7814-7820.
38. Petersen S.V., Thiel S., Jensenius J.C. The mannan-binding lectin pathway of complement activation: biology and disease association. Mol. Immunol. 2001, 38:133-149.
39. Petri M., Watson R., Winkelstein J.A., Mclean R.H. Clinical expression of systemic lupus erythematosus in patients with C4A deficiency. Medicine (Baltimore). 1993, 72:236-244.
40. Phatsara C., Jennen D.G.J., Ponsuksili S., Murani E., Tesfaye D., Schellander K., Wimmers K. Molecular genetic analysis of porcine mannose-binding lectin genes, MBL1 and MBL2, and their association with complement activity. Int. J. Immunogenet. 2007, 34:55-63.
41. Pickering M.C., Botto M., Taylor P.R., Lachmann P.J., Walport M.J. Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv. Immunol. 2000, 76:227-324.
42. Qiu H. Modern Dairy Science 2002, Agriculture Press of China, pp. 1-12.
43. Rainard P. The complement in milk and defense of the bovine mammary gland against infections. Vet. Res. 2003, 34:647-670.
44. Rainard P., Poutrel B. Deposition of complement components on Streptococcus agalactiae in bovine milk in the absence of inflammation. Infect. Immun. 1995, 63:3422-3427.
45. Rainard P., Poutrel B., Caffin J.B. Assessment of hemolytic and bactericidal complement activities in normal and mastitic bovine milk. J. Dairy Sci. 1984, 67:614-619.
46. Ratanachaiyavong S., Lloyd L., McGregor A.M. C4A gene deletion: association with Graves' disease. J. Mol. Endocrinol. 1989, 3:145-153.
47. Reiter B., Brock J.H. Inhibition of Escherichia coli by bovine colostrum and post-colostral milk. I. Complement-mediated bactericidal activity of antibodies to a serum susceptible strain of E. coli of the serotype O 111. Immunology 1975, 28:71-82.
48. Robson T., Heard R.N.S., Giles C.M. An epitope on C4 β light (L) chains detected by human anti-Rg; its relationship with β chain polymorphism and MHC associations. Immunogenetics 1989, 30:344-349.
49. Rosenfeld S.I., Baum J., Steigbigel R.T., Leddy J.P. Hereditary deficiency of the fifth component of complement in man. II. Biological properties of C5-deficient human serum. J. Clin. Invest. 1976, 57:1635-1643.
50. Ross S.C., Densen P. Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infection in an immune deficiency. Medicine (Baltimore). 1984, 63:243-273.
51. Rupp R., Boichard D. Genetic parameters for clinical mastitis, somatic cell score, production, udder type traits and milking ease in first lactation Holsteins. J. Dairy Sci. 1999, 82:2198-2204.
52. Rupp R., Boichard D. Genetics of resistance to mastitis in dairy cattle. Vet. Res. 2003, 34:671-688.
53. Samano E.S.T., Ribeiro L.M., Gorescu R.G., Rocha K.C., Grumach A.S. Involvement of C4 allotypes in the pathogenesis of human diseases. Rev. Hosp. Clin. Fac. Med. Sao Paulo 2004, 59:138-144.
54. Seegers H., Fourichon C., Beaudeau F. Production effects related to mastitis and mastitis economics in dairy cattle herds. Vet. Res. 2003, 34:475-491.
55. Shi L., Takahashi K., Dundee J., Shahroor-kami S., Thiel S., Jensenius J.C., Gad F., Hamblin M.R., Sastry K.N., Ezekowitz R.A. Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J. Exp. Med. 2004, 199:1379-1390.
56. Shi Y.Y., He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005, 15:97-98.
57. Shook G.E., Schutz M.M. Selection on somatic cell score to improve resistance to mastitis in the United States. J. Dairy Sci. 1994, 77:648-658.
58. Shuster D.E., Kehrli J.M.E., Rainard P., Paape M. Complement fragment C5a and inflammatory cytokines in neutrophil recruitment during intramammary infection with Escherichia coli. Infect. Immun. 1997, 65:3286-3292.
59. Sjoholm A.G., Jonsson G., Braconier J.H., Sturfelt G., Truedsson L. Complement deficiency and disease: an update. Mol. Immunol. 2006, 43:78-85.
60. Tan Y.J., Liu L.F., Luo P., Wang A.X., Jia T.J., Shen X.L., Wang M., Zhang S.M. Association between mannose-binding lectin and HIV infection and progression in a Chinese population. Mol. Immunol. 2009, 47:632-638.
61. Tao Q., Yu M.X., Zhao Y.H., Wang D.X., Liu X. Survey of incidence of cow mastitis in west Liaoning and the integrated control measures. China Cattle Sci. 2007, 4:61-63.
62. Teisberg P., Olaisen B., Jonassen R., Gedde-Dahl T.J., Thorsby E. The genetic polymorphism of the fourth component of human complement: methodological aspects and a presentation of linkage and association data relevant to its localization in the HLA region. J. Exp. Med. 1977, 146:1380-1389.
63. Vergani D., Johnston C., B-Abdullah N., Barnett A.H. Low serum C4 concentrations: an inherited predisposition to insulin dependent diabetes?. Br. Med. J. 1983, 286:926-928.
64. Wambura P.N., Gwakisa P.S., Silayo R.S., Rugaimukamu E.A. Breed-associated resistance to tick infestation in Bos indicus and their crosses with Bos taurus. Vet. Parasitol. 1998, 77:63-70.
65. Wang C.F., Liu M., Li Q.L., Ju Z.H., Huang J.M., Li J.B., Zhong J.F. Three novel single-nucleotide polymorphisms of MBL1 gene in Chinese native cattle and their associations with milk performance traits. Vet. Immunol. Immunopathol. 2011, 139:229-236.
66. Warner C.M., Meeker D.L., Rothschild M.F. Genetic control of immune responsiveness: a review of its use a tool for selection for disease resistance. J. Anim. Sci. 1987, 64:394-406.
67. Weigel K.A., Freeman A.E., Kehrli M.E., Stear M.J., Kelley D.H. Association of class I bovine lymphocyte antigen complex alleles with health and production traits in dairy cattle. J. Dairy Sci. 1990, 73:2538-2546.
68. Wiegertjes G.F., Yano T., van Muiswinkel W.B. Estimation of the genetic variation in complement activity of common carp (Cyprinus carpio L.). Vet. Immunol. Immunopathol. 1993, 37:309-319.
69. Yang Y., Chung E.K., Wu Y.L., Savelli S.L., Nagaraja H.N., Zhou B., Hebert M., Jones K.N., Shu Y., Kitzmiller K., Blanchong C.A., McBride K.L., Higgins G.C., Rennebohm R.M., Rice R.R., Hackshaw K.V., Roubey R.A., Grossman J.M., Tsao B.P., Birmingham D.J., Rovin B.H., Hebert L.A., Yu C.Y. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. Am. J. Hum. Genet. 2007, 80:1037-1054.
70. Yang Y., Chung E.K., Zhou B., Blanchong C.A., Yu Y., Füst G., Kovács M., Vatay Á., Szalai C., Karádi I., Varga L. Diversity in intrinsic strengths of the human complement system: serum C4 protein concentrations correlate with C4 gene size and polygenic variations, hemolytic activities, and body mass index. J. Immunol. 2003, 171:2734-2745.
71. Yu C.Y. The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene. J. Immunol. 1991, 146:1057-1066.
72. Zhao F., Zhao Z., Yan G., Wang D., Ban Q., Yu P., Zhang W., Luo Y. Polymorphisms in mannose-binding lectin (MBL) gene and their association with MBL protein levels in serum in the Hu sheep. Vet. Immunol. Immunopathol. 2011, 140:297-302.
73. Zipfel P.F., Reuter M. Complement activation products C3a and C4a as endogenous antimicrobial peptides. Int. J. Pept. Ther. 2009, 15:87-95.