Oncolytic sindbis virus targets tumors defective in the interferon response and induces significant bystander antitumor immunity in vivo

Molecular Therapy

Volumn 20, Issue 2, 2012, Pages 298-305

  Huang, Pong Yu ^a   Guo, Jih Huong ^a   Hwang, Lih Hwa ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTOKINE; INTERFERON; ONCOLYTIC VIRUS; VIRUS RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BYSTANDER EFFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG TARGETING; EXPERIMENTAL DESIGN; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; ONCOLYTIC VIROTHERAPY; SIGNAL TRANSDUCTION; SINDBIS VIRUS; SUBCUTANEOUS TISSUE TUMOR; TUMOR IMMUNITY; VIRAL GENE DELIVERY SYSTEM; VIRAL TROPISM;

ANIMALIA; MUS; SINDBIS VIRUS;

EID: 84856554267     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.245     Document Type: Article

References (27)

1. Tseng, JC, Levin, B, Hirano, T, Yee, H, Pampeno, C and Meruelo, D (2002). In vivo antitumor activity of Sindbis viral vectors. J Natl Cancer Inst 94: 1790-1802. (Pubitemid 36004355)
2. Tseng, JC, Hurtado, A, Yee, H, Levin, B, Boivin, C, Benet, M et al. (2004). Using sindbis viral vectors for specific detection and suppression of advanced ovarian cancer in animal models. Cancer Res 64: 6684-6692. (Pubitemid 39297931)
3. Tseng, JC, Levin, B, Hurtado, A, Yee, H, Perez de Castro, I, Jimenez, M et al. (2004). Systemic tumor targeting and killing by Sindbis viral vectors. Nat Biotechnol 22: 70-77. (Pubitemid 38057959)
4. Unno, Y, Shino, Y, Kondo, F, Igarashi, N, Wang, G, Shimura, R et al. (2005). Oncolytic viral therapy for cervical and ovarian cancer cells by Sindbis virus AR339 strain. Clin Cancer Res 11: 4553-4560. (Pubitemid 40825646)
5. Wollmann, G, Tattersall, P and van den Pol, AN (2005). Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential. J Virol 79: 6005-6022. (Pubitemid 40617207)
6. Strauss, JH and Strauss, EG (1994). The alphaviruses: gene expression, replication, and evolution. Microbiol Rev 58: 491-562.
7. Montuori, N and Sobel, ME (1996). The 67-kDa laminin receptor and tumor progression. Curr Top Microbiol Immunol 213 (Pt 1): 205-214. (Pubitemid 26165091)
8. Wang, KS, Kuhn, RJ, Strauss, EG, Ou, S and Strauss, JH (1992). High-affinity laminin receptor is a receptor for Sindbis virus in mammalian cells. J Virol 66: 4992-5001.
9. Byrnes, AP and Griffin, DE (1998). Binding of Sindbis virus to cell surface heparan sulfate. J Virol 72: 7349-7356. (Pubitemid 28377866)
10. Krishnamurthy, S, Takimoto, T, Scroggs, RA and Portner, A (2006). Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines. J Virol 80: 5145-5155.
11. Stojdl, DF, Lichty, B, Knowles, S, Marius, R, Atkins, H, Sonenberg, N et al. (2000). Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med 6: 821-825. (Pubitemid 30469434)
12. Parato, KA, Senger, D, Forsyth, PA and Bell, JC (2005). Recent progress in the battle between oncolytic viruses and tumours. Nat Rev Cancer 5: 965-976. (Pubitemid 41766784)
13. Ryman, KD, Klimstra, WB, Nguyen, KB, Biron, CA and Johnston, RE (2000). Alpha/beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropism. J Virol 74: 3366-3378. (Pubitemid 30143762)
14. Gorchakov, R, Frolova, E, Williams, BR, Rice, CM and Frolov, I (2004). PKR-dependent and-independent mechanisms are involved in translational shutoff during Sindbis virus infection. J Virol 78: 8455-8467. (Pubitemid 39025111)
15. Ryman, KD, Meier, KC, Nangle, EM, Ragsdale, SL, Korneeva, NL, Rhoads, RE et al. (2005). Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells. J Virol 79: 1487-1499. (Pubitemid 40459096)
16. Zhang, Y, Burke, CW, Ryman, KD and Klimstra, WB (2007). Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J Virol 81: 11246-11255. (Pubitemid 47536097)
17. van Boxel-Dezaire, AH, Rani, MR and Stark, GR (2006). Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 25: 361-372. (Pubitemid 44354225)
18. Kawai, T and Akira, S (2010). The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
19. Yoneyama, M, Kikuchi, M, Natsukawa, T, Shinobu, N, Imaizumi, T, Miyagishi, M et al. (2004). The RNA helicase RIG-I has an essential function in double-stranded RNAinduced innate antiviral responses. Nat Immunol 5: 730-737. (Pubitemid 39023305)
20. Yoneyama, M, Kikuchi, M, Matsumoto, K, Imaizumi, T, Miyagishi, M, Taira, K et al. (2005). Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 175: 2851-2858. (Pubitemid 41170502)
21. Zamarin, D, Martínez-Sobrido, L, Kelly, K, Mansour, M, Sheng, G, Vigil, A et al. (2009). Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses. Mol Ther 17: 697-706.
22. Sobol, PT, Boudreau, JE, Stephenson, K, Wan, Y, Lichty, BD and Mossman, KL (2011). Adaptive antiviral immunity is a determinant of the therapeutic success of oncolytic virotherapy. Mol Ther 19: 335-344.
23. Gujar, SA, Pan, DA, Marcato, P, Garant, KA and Lee, PW (2011). Oncolytic virusinitiated protective immunity against prostate cancer. Mol Ther 19: 797-804.
24. Prestwich, RJ, Harrington, KJ, Pandha, HS, Vile, RG, Melcher, AA and Errington, F (2008). Oncolytic viruses: a novel form of immunotherapy. Expert Rev Anticancer Ther 8: 1581-1588.
25. Cheng, EH, Levine, B, Boise, LH, Thompson, CB and Hardwick, JM (1996). Baxindependent inhibition of apoptosis by Bcl-XL. Nature 379: 554-556.
26. Thomas, JM, Klimstra, WB, Ryman, KD and Heidner, HW (2003). Sindbis virus vectors designed to express a foreign protein as a cleavable component of the viral structural polyprotein. J Virol 77: 5598-5606. (Pubitemid 36538952)
27. Morizono, K, Bristol, G, Xie, YM, Kung, SK and Chen, IS (2001). Antibody-directed targeting of retroviral vectors via cell surface antigens. J Virol 75: 8016-8020. (Pubitemid 32743673)