Author's response to Steward et al., "A re-assessment of the effects of intra-cortical delivery of inosine...."

Experimental Neurology

Volumn 233, Issue 2, 2012, Pages 674-676

  Benowitz, Larry ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INOSINE;

CELL COUNT; CELL LABELING; CELL POPULATION; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; NERVE CELL LESION; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVE FIBER TRANSPORT; NERVE SPROUTING; NONHUMAN; NOTE; PRIORITY JOURNAL; PYRAMIDAL TRACT; SENSORIMOTOR CORTEX; SPINAL CORD INJURY;

ANIMALS; AXONS; CEREBRAL CORTEX; DRUG DELIVERY SYSTEMS; INOSINE; MALE; MEDULLA OBLONGATA; PYRAMIDAL TRACTS;

EID: 84856549515     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.09.034     Document Type: Note

References (6)

1. Benowitz L.I., Goldberg D.E., Madsen J.R., Soni D., Irwin N. Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:13486-13490.
2. Chen P., Goldberg D.E., Kolb B., Lanser M., Benowitz L.I. Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:9031-9036.
3. Maier I.C., Baumann K., Thallmair M., Weinmann O., Scholl J., Schwab M.E. Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury. J. Neurosci. 2008, 28:9386-9403.
4. Smith J.M., Lunga P., Story D., Harris N., Le Belle J., James M.F., Pickard J.D., Fawcett J.W. Inosine promotes recovery of skilled motor function in a model of focal brain injury. Brain 2007, 130:915-925.
5. Zai L., Ferrari C., Dice C., Subbaiah S., Havton L.A., Coppola G., Geschwind D., Irwin N., Huebner H., Strittmatter S.M., Benowitz L.I. Inosine augments the effects of a Nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke. J. Neurosci. 2011, 31:5977-5988.
6. Zai L., Ferrari C., Subbaiah S., Havton L.A., Coppola G., Strittmatter S., Irwin N., Geschwind D., Benowitz L.I. Inosine alters gene expression and axonal projections in neurons contralateral to a cortical infarct and improves skilled use of the impaired limb. J. Neurosci. 2009, 29:8187-8197.