Enhancement of anthraquinone production in Morinda citrifolia cell suspension cultures after stimulation of the proline cycle with two proline analogs

Biotechnology Letters

Volumn 34, Issue 3, 2012, Pages 571-575

  Quevedo, Carla V ^a   Perassolo, María ^a   Giulietti, Ana M ^a   Talou, Julián Rodríguez ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Anthraquinones; Azetidine 2 carboxylic acid; Morinda citrifolia; Proline cycle; Thiazolidine 4 carboxylic acid

Indexed keywords

2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE PATHWAYS; ANTHRAQUINONES; CARBON SKELETON; CELL SUSPENSION CULTURES; METABOLIC PATHWAYS; MORINDA CITRIFOLIA; PENTOSE PHOSPHATE PATHWAY; PROLINE ACCUMULATION; PROLINE CYCLE; SHIKIMATES; SUSPENSION CULTURES; THIAZOLIDINE-4-CARBOXYLIC ACID; TOTAL PHENOLICS;

CARBOXYLIC ACIDS; CELL CULTURE; INTERNET PROTOCOLS; KETONES; ORGANIC COMPOUNDS; PHENOLS; SUSPENSIONS (FLUIDS);

AMINO ACIDS;

ANTHRAQUINONE DERIVATIVE; AZETIDINE 2 CARBOXYLIC ACID; DRUG DERIVATIVE; PHENOL DERIVATIVE; PROLINE; THIAZOLIDINE DERIVATIVE; THIAZOLIDINE-4-CARBOXYLIC ACID; TIMONACIC;

ARTICLE; CELL CULTURE; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECT; METABOLISM; MORINDA; TIME; TRANSCRIPTION INITIATION;

ANTHRAQUINONES; AZETIDINECARBOXYLIC ACID; CELLS, CULTURED; CULTURE MEDIA; MORINDA; PHENOLS; PROLINE; THIAZOLIDINES; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION;

MORINDA CITRIFOLIA;

EID: 84856533666     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-011-0806-2     Document Type: Article

References (15)

1. Armero J, Requejo R, Jorrín J, López-Valbuena R, Tena M (2001) Release of phytoalexins and related isoflavonoids from intact chickpea seedlings elicited with reduced glutathione at root level. Plant Physiol Biochem 39(3): 785-795. doi: 10. 1016/S0981-9428(01)01299-2.
2. Bates LS, Waldren RP, Teare ID (1973) Rapid determination of free proline for water-stress studies. Plant Soil 39(1): 205-207. doi: 10. 1007/BF00018060.
3. Di Rienzo JA, Casanoves F, Balzarini MG, Gonzalez L, Tablada M, Robledo CW (2010) InfoStat versión 2010. Grupo InfoStat. FCA, Universidad Nacional de Córdoba, Argentina.
4. Han YS, van der Heijden R, Verpoorte R (2001) Biosynthesis of anthraquinones in cell cultures of the Rubiaceae. Plant Cell Tiss Organ Cult 67(3): 201-220. doi: 10. 1023/A: 1012758922713.
5. Moreno PRH, van der Heijden R, Verpoorte R (1994) Elicitor-mediated induction of isochorismate synthase and accumulation of 2, 3-dihydroxy benzoic acid in Catharanthus roseus cell suspension and shoot cultures. Plant Cell Rep 14(2-3): 188-191. doi: 10. 1007/BF00233788.
6. Perassolo M, Quevedo CV, Giulietti AM, Rodríguez Talou J (2011) Stimulation of the proline cycle and anthraquinone accumulation in Rubia tinctorum cell suspension cultures in the presence of glutamate and two proline analogs. Plant Cell Tiss Organ Cult 106: 153-159. doi: 10. 1007/s11240-010-9903-5.
7. Quevedo C, Perassolo M, Alechine E, Corach D, Giulietti AM, Talou JR (2010) Increasing anthraquinone production by overexpression of 1-deoxy-D-xylulose-5-phosphate synthase in transgenic cell suspension cultures of Morinda citrifolia. Biotechnol Lett 32: 997-1003. doi: 10. 1007/s10529-010-0250-8.
8. Rao SR, Ravishankar GA (2002) Plant cell cultures: chemical factories of secondary metabolites. Biotechnol Adv 20(2): 101-153. doi: S0734975002000071.
9. Schulte U, El-Shagi H, Zenk MH (1984) Optimization of 19 Rubiaceae species in cell culture for the production of anthraquinones. Plant Cell Rep 3(2): 51-54. doi: 10. 1007/BF00270970.
10. Shetty K (2004) Role of proline-linked pentose phosphate pathway in biosynthesis of plant phenolics for functional food and environmental applications: a review. Proc Biochem 39: 789-803.
11. Shetty P, Atallah MT, Shetty K (2003) Stimulation of total phenolics, L-DOPA and antioxidant activity through proline-linked pentose phosphate pathway in response to proline and its analogue in germinating fava beans (Vicia faba). Proc Biochem 38(12): 1707-1717. doi: 10. 1016/S0032-9592(02)00257-1.
12. Tarmizi AH, Marziah M (2000) Studies towards understanding proline accumulation in oil plam (Elaeis guineensis Jacq.) polyembryogenic cultures. J Oil Palm Res 12(1): 8-13.
13. Vasconsuelo A, Giulietti AM, Picotto G, Rodríguez Talou J, Boland R (2003) Involvement of the PLC/PKC pathway in Chitosan-induced anthraquinone production by Rubia tinctorum L. Cell cultures Plant Sci 165(2): 429-436. doi: 10. 1016/S0168-9452(03)00208-5.
14. Verpoorte R, Memelink J (2002) Engineering secondary metabolite production in plants. Curr Opin Biotechnol 13(2): 181-187. doi: S0958166902003087.
15. Yang R, Shetty K (1998) Stimulation of rosmarinic acid in shoot cultures of oregano (Origanum vulgare) clonal line in response to proline, proline analogue, and proline precursors. J Agric Food Chem 46: 2888-2893.