Urinary proteome analysis to exclude severe vesicoureteral reflux

Pediatrics

Volumn 129, Issue 2, 2012, Pages

  Drube, Jens ^a   Schiffer, Eric ^b   Lau, Esther ^a   Petersen, Claus ^a   Kirschstein, Martin ^c   Kemper, Markus J ^d   Lichtinghagen, Ralf ^a   Ure, Benno ^a   Mischak, Harald ^b,e   Pape, Lars ^a   Ehrich, Jochen H H ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b MOSAIQUES DIAGNOSTICS GMBH   (Germany)

^c General Hospital   (Germany)

^d UNIVERSITY OF HAMBURG   (Germany)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Noninvasive diagnostics; Proteomics; Screening; Vesicoureteral reflux

Indexed keywords

ACCURACY; ADOLESCENT; ARTICLE; CAPILLARY ELECTROPHORESIS; CASE CONTROL STUDY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HYDRONEPHROSIS; INFANT; MALE; MASS SPECTROMETRY; NON INVASIVE PROCEDURE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN URINE LEVEL; PROTEOMICS; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; URINARY TRACT INFECTION; VESICOURETERAL REFLUX;

ADOLESCENT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; ELECTROPHORESIS, CAPILLARY; FEMALE; HUMANS; HYDRONEPHROSIS; INFANT; MALE; MASS SPECTROMETRY; PEPTIDES; PREDICTIVE VALUE OF TESTS; PROTEOME; ULTRASONOGRAPHY; URINARY TRACT INFECTIONS; VESICO-URETERAL REFLUX;

EID: 84856521374     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-3467     Document Type: Article

References (59)

1. American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection. Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics. 1999;103(4 Pt 1):843-852
2. Lebowitz RL, Olbing H, Parkkulainen KV, Smellie JM, Tamminen-Möbius TE; International Reflux Study in Children. International system of radiographic grading of vesicoureteric reflux. Pediatr Radiol. 1985;15(2):105-109 (Pubitemid 15198933)
3. Oberson C, Boubaker A, Ramseyer P, Meyrat BJ, Frey P. Endoscopic and surgical treatment of vesico-ureteral reflux in children. Comparative long-term follow-up. Swiss Med Wkly. 2007;137(33-34):471-475 (Pubitemid 47346423)
4. Leonardo CR, Filgueiras MFT, Vasconcelos MM, et al. Risk factors for renal scarring in children and adolescents with lower urinary tract dysfunction. Pediatr Nephrol. 2007;22(11):1891-1896 (Pubitemid 47506229)
5. Mahant S, Friedman J, MacArthur C. Renal ultrasound findings and vesicoureteral reflux in children hospitalised with urinary tract infection. Arch Dis Child. 2002;86(6):419-420
6. Berrocal T, Gayá F, Arjonilla A, Lonergan GJ. Vesicoureteral reflux: diagnosis and grading with echo-enhanced cystosonography versus voiding cystourethrography. Radiology. 2001;221(2):359-365 (Pubitemid 33043417)
7. Herd DW. Anxiety in children undergoing VCUG: sedation or no sedation? Adv Urol. 2008:498614.
8. Newman TB. Much pain, little gain from voiding cystourethrograms after urinary tract infection. Pediatrics. 2006;118(5):2251-, author reply 2251-2252
9. Wald ER. Vesicoureteral reflux: the role of antibiotic prophylaxis. Pediatrics. 2006;117(3):919-922 (Pubitemid 46063235)
10. Darge K. Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations. Pediatr Radiol. 2008;38(1):54-63, quiz 126-127
11. Darge K. Voiding urosonography with US contrast agent for the diagnosis of vesicoureteric reflux in children: an update. Pediatr Radiol. 2010;40(6):956-962
12. Lee HY, Soh BH, Hong CH, Kim MJ, Han SW. The efficacy of ultrasound and dimercaptosuccinic acid scan in predicting vesicoureteral reflux in children below the age of 2 years with their first febrile urinary tract infection. Pediatr Nephrol. 2009;24(10):2009-2013
13. Preda I, Jodal U, Sixt R, et al. Normal dimercaptosuccinic acid scintigraphy makes voiding cystourethrography unnecessary after urinary tract infection. J Pediatr. 2007;151(6):581, 584
14. Hansson S, Dhamey M, Sigström O, et al. Dimercapto-succinic acid scintigraphy instead of voiding cystourethrography for infants with urinary tract infection. J Urol. 2004;172(3):1071-1073, discussion 1073-1074
15. Keren R. Imaging and treatment strategies for children after first urinary tract infection. Curr Opin Pediatr. 2007;19(6):705-710 (Pubitemid 350145242)
16. Downs SM; The Urinary Tract Subcommittee of the American Academy of Pediatrics Committee on Quality Improvement. Technical report: urinary tract infections in febrile infants and young children. Pediatrics. 1999;103(4):e54
17. Hoberman A, Wald ER, Hickey RW, et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999;104(1 Pt 1):79-86 (Pubitemid 29315851)
18. Ajdinović B, Jauković L, Krstić Z, Dopuda M. Impact of micturating cystourethrography and DMSA renal scintigraphy on the investigation scheme in children with urinary tract infection. Ann Nucl Med. 2008;22(8):661-665
19. Zaffanello M, Cataldi L, Brugnara M, Franchini M, Bruno C, Fanos V. Hidden high-grade vesicoureteral reflux is the main risk factor for chronic renal damage in children under the age of two years with first urinary tract infection. Scand J Urol Nephrol. 2009;43(6):494-500
20. APN-Konsensusgruppe; Arbeitskreis Kinderurologie In Der Deutschen Gesellschaft Für Urologie; Arbeitsgemeinschaft Kinderurologie Der Deutschen Gesellschaft Für Kinderchirurgie. Consensus on diagnostic strategies in connatal dilatations of the urinary tract [in German]. Aktuelle Urol. 2002;33(1):36-45
21. Eknoyan G, Levin NW. Impact of the new K/DOQI guidelines. Blood Purif. 2002;20(1):103-108 (Pubitemid 34102515)
22. Schwartz GJ, Muñoz A, Schneider MF, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20(3):629-637
23. Lun A, Suslovych M, Drube J, Ziebig R, Pavicic L, Ehrich JH. Reliability of different expert systems for profiling proteinuria in children with kidney diseases. Pediatr Nephrol. 2008;23(2):285-290
24. Good DM, Zürbig P, Argilés A, et al. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics. 2010;9(11):2424-2437
25. Girolami M, Mischak H, Krebs R. Analysis of complex, multidimensional datasets. Drug Discov Today Technol. 2007;3(1):12-19
26. Yang ZR. Biological applications of support vector machines. Brief Bioinform. 2004;5(4):328-338
27. Weissinger EM, Wittke S, Kaiser T, et al. Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes. Kidney Int. 2004;65(6):2426-2434 (Pubitemid 38670029)
28. Yang ZR, Chou KC. Bio-support vector machines for computational proteomics. Bioinformatics. 2004;20(5):735-741 (Pubitemid 38443829)
29. Zürbig P, Renfrow MB, Schiffer E, et al. Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separation. Electrophoresis. 2006;27(11):2111-2125 (Pubitemid 43942113)
30. Vlahou A, Allmaier G, Attwood T, et al. 2nd combined working group and management committee meeting of urine and kidney proteomics COST action, 29-March 30, 2009, Nafplio, Greece. Proteomics Clin Appl. 2009;3(9):1017-1022
31. Mischak H, Allmaier G, Apweiler R, et al. Recommendations for biomarker identification and qualification in clinical proteomics. Sci Transl Med. 2010;2(46):46ps42
32. Wong SN, Tse NK, Lee KP, et al. Evaluating different imaging strategies in children after first febrile urinary tract infection. Pediatr Nephrol. 2010;25(10):2083-2091
33. Rossing K, Mischak H, Rossing P, Schanstra JP, Wiseman A, Maahs DM. The urinary proteome in diabetes and diabetes-associated complications: new ways to assess disease progression and evaluate therapy. Proteomics Clin Appl. 2008;2(7-8):997-1007
34. Rossing K, Mischak H, Dakna M, et al PREDICTIONS Network. Urinary proteomics in diabetes and CKD. J Am Soc Nephrol. 2008;19(7):1283-1290
35. Foucher C, Schiffer E, Mischak H, Ansquer JC, Wilbraham D. Effect of fenofibrate treatment on the low molecular weight urinary proteome of healthy volunteers. Proteomics Clin Appl. 2011;5(3-4):159-166
36. Xuan Y, Kim S, Lin Z. Protein expression and gene promoter hypermethylation of CD99 in transitional cell carcinoma of urinary bladder. J Cancer Res Clin Oncol. 2011;137(1):49-54
37. Baek M, Paick SH, Jeong SJ, Hong SK, Kim SW, Choi H. Urodynamic and histological changes in a sterile rabbit vesicoureteral reflux model. J Korean Med Sci. 2010;25(9):1352-1358
38. Decramer S, Wittke S, Mischak H, et al. Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis. Nat Med. 2006;12(4):398-400
39. Konda R, Sakai K, Ota S, Takeda A, Orikasa S. Followup study of renal function in children with reflux nephropathy after resolution of vesicoureteral reflux. J Urol. 1997;157(3):975-979 (Pubitemid 27066300)
40. Everaert K, Hoebeke P, Delanghe J. A review on urinary proteins in outflow disease of the upper urinary tract. Clin Chim Acta. 2000;297(1-2):183- 189 (Pubitemid 30332289)
41. Basic J, Golubovic E, Miljkovic P, et al. Microalbuminuria in children with vesicoureteral reflux. Ren Fail. 2008;30(6):639-643
42. Fliser D, Novak J, Thongboonkerd V, et al. Advances in urinary proteome analysis and biomarker discovery. J Am Soc Nephrol. 2007;18(4):1057-1071 (Pubitemid 46536892)
43. Schaub S, Wilkins J, Weiler T, Sangster K, Rush D, Nickerson P. Urine protein profiling with surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry. Kidney Int. 2004;65(1):323-332 (Pubitemid 38037520)
44. Theodorescu D, Wittke S, Ross MM, et al. Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol. 2006;7(3):230-240 (Pubitemid 43286453)
45. Jantos-Siwy J, Schiffer E, Brand K, et al. Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease. J Proteome Res. 2009;8(1):268-281
46. Drube J, Zürbig P, Schiffer E, et al. Urinary proteome analysis identifies infants but not older children requiring pyeloplasty. Pediatr Nephrol. 2010;25(9):1673-1678
47. Mesrobian HG. Urinary proteome analysis and the management of ureteropelvic junction obstruction. Pediatr Nephrol. 2010;25(9):1595-1596
48. Kobayashi H, Miyakita H, Yamataka A, Koga H, Lane GJ, Miyano T. Serum basic fibroblast growth factor as a marker of reflux nephropathy. J Pediatr Surg. 2004;39(12):1853-1855 (Pubitemid 40017736)
49. Leroy S, Adamsbaum C, Marc E, et al. Procalcitonin as a predictor of vesicoureteral reflux in children with a first febrile urinary tract infection. Pediatrics. 2005;115(6):e706-e709 (Pubitemid 43843144)
50. Kaneyama K, Kobayashi H, Yamataka A, Lane GJ, Miyano T. Serum soluble vascular cell adhesion molecule-1 (VCAM-1) concentrations in children with reflux nephropathy. Pediatr Surg Int. 2005;21(1):39-42 (Pubitemid 40169457)
51. Galanakis E, Bitsori M, Dimitriou H, Giannakopoulou C, Karkavitsas NS, Kalmanti M. Urine interleukin-8 as a marker of vesicoureteral reflux in infants. Pediatrics. 2006;117(5):e863-e867 (Pubitemid 46071353)
52. Gokce I, Alpay H, Biyikli N, Unluguzel G, Dede F, Topuzoglu A. Urinary levels of interleukin-6 and interleukin-8 in patients with vesicoureteral reflux and renal parenchymal scar. Pediatr Nephrol. 2010;25(5):905-912
53. Sabasiñska A, Zoch-Zwierz W, Wasilewska A, Porowski T. Laminin and transforming growth factor beta-1 in children with vesicoureteric reflux. Pediatr Nephrol. 2008;23(5):769-774
54. Mantadakis E, Plessa E, Vouloumanou EK, Karageorgopoulos DE, Chatzimichael A, Falagas ME. Serum procalcitonin for prediction of renal parenchymal involvement in children with urinary tract infections: a meta-analysis of prospective clinical studies. J Pediatr. 2009;155(6):875-881, e1
55. Müller L, Preda I, Jacobsson B, et al. Ultrasonography as predictor of permanent renal damage in infants with urinary tract infection. Acta Paediatr. 2009;98(7):1156-1161
56. Smellie J, Edwards D, Hunter N, Normand IC, Prescod N. Vesico-ureteric reflux and renal scarring. Kidney Int Suppl. 1975;4:S65-S72
57. Benador D, Benador N, Slosman D, Mermillod B, Girardin E. Are younger children at highest risk of renal sequelae after pyelonephritis? Lancet. 1997;349(9044):17-19 (Pubitemid 27022986)
58. González E, Papazyan JP, Girardin E. Impact of vesicoureteral reflux on the size of renal lesions after an episode of acute pyelonephritis. J Urol. 2005;173(2):571-574, discussion 574-575
59. Silva JM, Diniz JS, Lima EM, et al. Independent risk factors for renal damage in a series of primary vesicoureteral reflux: a multivariate analysis. Nephrology (Carlton). 2009;14(2):198-204