Defining the boundaries of normal thrombin generation: Investigations into hemostasis

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Danforth, Christopher M ^a   Orfeo, Thomas ^b   Everse, Stephen J ^b   Mann, Kenneth G ^b   Brummel Ziedins, Kathleen E ^b  

^a University of Vermont   (United States)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; BLOOD CLOTTING FACTOR; PROTEOME; RECOMBINANT BLOOD CLOTTING FACTOR 8; THROMBIN; WARFARIN;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; CORRELATION COEFFICIENT; EMPIRICAL RESEARCH; FEMALE; HEART ATRIUM FIBRILLATION; HEMOPHILIA; HEMOPHILIA A; HEMOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL MODEL; PHENOTYPE; PROSTHETIC VALVE THROMBOSIS; SENSITIVITY ANALYSIS; VENOUS THROMBOEMBOLISM; BIOLOGY; BIOSYNTHESIS; METHODOLOGY; STANDARD;

BLOOD COAGULATION; COMPUTATIONAL BIOLOGY; HEMOSTASIS; HUMANS; PROTEOME; THROMBIN;

EID: 84856494507     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030385     Document Type: Article

References (41)

1. Crawley JT, Zanardelli S, Chion CK, Lane DA, (2007) The central role of thrombin in hemostasis. J Thromb Haemost 5 (Suppl 1): 95-101.
2. Hockin MF, Jones KC, Everse SJ, Mann KG, (2002) A model for the stoichiometric regulation of blood coagulation. J Biol Chem 277: 18322-18333.
3. Panteleev MA, Ovanesov MV, Kireev DA, Shibeko AM, Sinauridze EI, et al. (2006) Spatial propagation and localization of blood coagulation are regulated by intrinsic and protein C pathways, respectively. Biophys J 90: 1489-1500.
4. Luan D, Zai M, Varner JD, (2007) Computationally derived points of fragility of a human cascade are consistent with current therapeutic strategies. PLoS Comput Biol 3: e142.
5. Anand M, Rajagopal K, Rajagopal KR, (2008) A model for the formation, growth, and lysis of clots in quiescent plasma. A comparison between the effects of antithrombin III deficiency and protein C deficiency. J Theor Biol.
6. Chatterjee MS, Denney WS, Jing H, Diamond SL, (2010) Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood. PLoS Comput Biol 6.
7. Mitrophanov AY, Reifman J, (2011) Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation. Thrombosis research 128: 381-390.
8. Hall CL, Slack SM, Turitto VT, (1998) A computational analysis of FXa generation by TF:FVIIa on the surface of rat vascular smooth muscle cells. Annals of biomedical engineering 26: 28-36.
9. Kuharsky AL, Fogelson AL, (2001) Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition. Biophys J 80: 1050-1074.
10. Ataullakhanov FI, Panteleev MA, (2005) Mathematical modeling and computer simulation in blood coagulation. Pathophysiol Haemost Thromb 34: 60-70.
11. Fogelson AL, Tania N, (2005) Coagulation under flow: the influence of flow-mediated transport on the initiation and inhibition of coagulation. Pathophysiol Haemost Thromb 34: 91-108.
12. Anand M, Rajagopal K, Rajagopal KR, (2008) A model for the formation, growth, and lysis of clots in quiescent plasma. A comparison between the effects of antithrombin III deficiency and protein C deficiency. J Theor Biol 253: 725-738.
13. Xu Z, Chen N, Kamocka MM, Rosen ED, Alber M, (2008) A multiscale model of thrombus development. J R Soc Interface 5: 705-722.
14. Runyon MK, Kastrup CJ, Johnson-Kerner BL, Ha TG, Ismagilov RF, (2008) Effects of shear rate on propagation of blood clotting determined using microfluidics and numerical simulations. J Am Chem Soc 130: 3458-3464.
15. Wajima T, Isbister GK, Duffull SB, (2009) A comprehensive model for the humoral coagulation network in humans. Clinical pharmacology and therapeutics 86: 290-298.
16. Xu Z, Kamocka M, Alber M, Rosen ED, (2011) Computational approaches to studying thrombus development. Arterioscler Thromb Vasc Biol 31: 500-505.
17. Brummel-Ziedins K, Vossen CY, Rosendaal FR, Umezaki K, Mann KG, (2005) The plasma hemostatic proteome: thrombin generation in healthy individuals. J Thromb Haemost 3: 1472-1481.
18. Brummel-Ziedins KE, Orfeo T, Rosendaal FR, Undas A, Rivard GE, et al. (2009) Empirical and theoretical phenotypic discrimination. J Thromb Haemost 7 (Suppl 1): 181-186.
19. Adams TE, Everse SJ, Mann KG, (2003) Predicting the pharmacology of thrombin inhibitors. J Thromb Haemost 1: 1024-1027.
20. Orfeo T, Butenas S, Brummel-Ziedins KE, Gissel M, Mann KG, (2010) Anticoagulation by factor Xa inhibitors. J Thromb Haemost 8: 1745-1753.
21. Orfeo T, Gissel M, Butenas S, Undas A, Brummel-Ziedins KE, et al. (2011) Anticoagulants and the propagation phase of thrombin generation. PloS one 6: e27852.
22. Danforth CM, Orfeo T, Mann KG, Brummel-Ziedins KE, Everse SJ, (2009) The impact of uncertainty in a blood coagulation model. Math Med Biol 26: 323-336.
23. Mann KG, Orfeo T, Butenas S, Undas A, Brummel-Ziedins K, (2009) Blood coagulation dynamics in haemostasis. Hamostaseologie 29: 7-16.
24. Brummel Ziedins KE, Orfeo T, Swords-Jenny N, Everse SJ, Mann KG, (2004) Blood coagulation and fibrinolysis. In: Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskevas F, editors. Wintrobe's Clinical Hematology Philidelphia Lippincott Williams & Wilkins pp. 677-774.
25. Rodgers GM, (2004) Diagnostic approach to the bleeding disorder. In: Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskevas F, editors. Wintrobe's Clinical Hematology Philidelphia Lippincott Williams & Wilkins pp. 1511-1528.
26. Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, et al. (2004) The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 204S-233S.
27. Hirsh J, Raschke R, (2004) Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 188S-203S.
28. Butenas S, Orfeo T, Gissel MT, Brummel KE, Mann KG, (2004) The significance of circulating factor IXa in blood. J Biol Chem 279: 22875-22882.
29. Shampine LF, Reichelt MW, (1997) The MATLAB ODE Suite. SIAM Journal on Scientific Computing 18: 1-22.
30. Hoyer LW, (1994) Hemophilia A. N Engl J Med 330: 38-47.
31. Bell B, Canty D, Audet M, (1995) Hemophilia: an updated review. Pediatr Rev 16: 290-298.
32. Lancellotti S, De Cristofaro R, (2009) Congenital prothrombin deficiency. Semin Thromb Hemost 35: 367-381.
33. Patnaik MM, Moll S, (2008) Inherited antithrombin deficiency: a review. Haemophilia 14: 1229-1239.
34. Khor B, Van Cott EM, (2010) Laboratory tests for antithrombin deficiency. American journal of hematology 85: 947-950.
35. Regnault V, Hemker HC, Wahl D, Lecompte T, (2004) Phenotyping the haemostatic system by thrombography-potential for the estimation of thrombotic risk. Thrombosis research 114: 539-545.
36. Hron G, Kollars M, Binder BR, Eichinger S, Kyrle PA, (2006) Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation. JAMA: the journal of the American Medical Association 296: 397-402.
37. van Veen JJ, Gatt A, Makris M, (2008) Thrombin generation testing in routine clinical practice: are we there yet? British journal of haematology 142: 889-903.
38. Robert S, Ghiotto J, Pirotte B, David JL, Masereel B, et al. (2009) Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs? Pharmacological research: the official journal of the Italian Pharmacological Society 59: 160-166.
39. Nair SC, Dargaud Y, Chitlur M, Srivastava A, (2010) Tests of global haemostasis and their applications in bleeding disorders. Haemophilia: the official journal of the World Federation of Hemophilia 16 (Suppl 5): 85-92.
40. Castoldi E, Rosing J, (2011) Thrombin generation tests. Thrombosis research 127 (Suppl 3): S21-25.
41. Ten Cate H, (2011) Thrombin generation in clinical conditions. Thrombosis research.