Cancer cell proliferation is inhibited by specific modulation frequencies

British Journal of Cancer

Volumn 106, Issue 2, 2012, Pages 307-313

  Zimmerman, J W ^a   Pennison, M J ^a   Brezovich, I ^b   Yi, N ^c   Yang, C T ^c   Ramaker, R ^a   Absher, D ^d   Myers, R M ^d   Kuster, N ^e   Costa, F P ^f   Barbault, A ^g   Pasche, B ^a  

^a University of Alabama at Birmingham   (United States)

^b The University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

^e FOUNDATION FOR RESEARCH ON INFORMATION TECHNOLOGIES IN SOCIETY IT IS   (Switzerland)

^f UNIVERSITY OF SÃO PAULO   (Brazil)

^g NONE   (France)

Author keywords

electromagnetic fields; hepatocelullar carcinoma; mitotic spindle; PLP2; XCL2

Indexed keywords

AMPLITUDE MODULATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ELECTROMAGNETIC FIELD; FEEDBACK SYSTEM; FREQUENCY MODULATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOSIS SPINDLE; PRIORITY JOURNAL;

EID: 84856473218     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.523     Document Type: Article

References (21)

1. Barbault A, Costa F, Bottger B, Munden R, Bomholt F, Kuster N, Pasche B (2009) Amplitude-modulated electromagnetic fields for the treatment of cancer: discovery of tumor-specific frequencies and assessment of a novel therapeutic approach. J Exp Clin Cancer Res 28(1): 51
2. Blackman C (2009) Cell phone radiation: evidence from ELF and RF studies supporting more inclusive risk identification and assessment. Pathophysiology 16: 205-216
3. Blank M, Goodman R (2008) A mechanism for stimulation of biosynthesis by electromagnetic fields: charge transfer in DNA and base pair separation. J Cell Physiol 214: 20-26 (Pubitemid 350220055)
4. Blank M, Goodman R (2009) Electromagnetic fields stress living cells. Pathophysiology 16: 71-78
5. Breitwieser GE, McLenithan JC, Cortese JF, Shields JM, Oliva MM, Majewski JL, Machamer CE, Yang VW (1997) Colonic epitheliumenriched protein A4 is a proteolipid that exhibits ion channel characteristcs. Am J Physiol 272(3 Pt 1): C957-C965
6. Brothman AR, Persons DL, Shaffer LG (2009) Nomenclature evolution: changes in the ISCN from the 2005 to the 2009 edition. Cytogenet Genome Res 127: 1-4
7. Costa FP, de Oliveira AC, Meirelles R, Machado MCC, Zanesco T, Surjan R, Chammas MC, de Souza Rocha M, Morgan D, Cantor A, Zimmerman J, Brezovich I, Kuster N, Barbault A, Pasche B (2011) Treatment of advanced hepatocellular carcinoma with very low levels of amplitudemodulated electromagnetic fields. Br J Cancer 105(5): 640-648
8. Kirson ED, Dbaly V, Tovarys F, Vymazal J, Soustiel JF, Itzhaki A, Mordechovich D, Steinberg-Shapira S, Gurvich Z, Schneiderman R, Wasserman Y, Salzberg M, Ryffel B, Goldsher D, Dekel E, Palti Y (2007) Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. PNAS 104(24): 10152-10157 (Pubitemid 47175278)
9. Kirson ED, Giladi M, Gurvich Z, Itzhaki A, Mordechovich D, Schneiderman RS, Wasserman Y, Ryffel B, Goldsher D, Palti Y (2009) Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs. Clin Exp Metastasis 26(7): 633-640.
10. Kirson ED, Gurvich Z, Schneiderman R, Dekel E, Itzhaki A, Wasserman Y, Schatzberger R, Palti Y (2004) Disruption of cancer cell replication by alternating electric fields. Cancer Res 64(9): 3288-3295 (Pubitemid 38581435)
11. Lee SM, Shin H, Jang SW, Shim JJ, Song IS, Son KN, Hwang J, Shin YH, Kim HH, Lee CK, Ko J, Na DS, Kwon BS, Kim J (2004) PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. Biochem Biophys Res Commun 324: 768-772 (Pubitemid 39345581)
12. Maher CA, Kumar-Sinha C, Cao X, Kalyana-Sundaram S, Han B, Jing X, Sam L, Barrette T, Palanisamy N, Chinnaiyan AM (2009) Transcriptome sequencing to detect gene fusions in cancer. Nature 458(7234): 97-101, doi:10.1038/nature07638
13. Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J (1982) Growth of human hepatoma cell lines with differentiated functions in chemically defined medium. Cancer Res 42: 3858-3863 (Pubitemid 12054507)
14. Reddy TE, Pauli F, Sprouse RO, Neff NF, Newberry KM, Garabedian MJ, Myers RM (2009) Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. Genome Res 19(12): 2163-2171
15. Rosman DS, Phukan S, Huang CC, Pasche B (2008) TGFBR1*6A enhances the migration and invasion of MCF-7 breast cancer cells through RhoA activation. Cancer Res 68(5): 1319-1328 (Pubitemid 351346838)
16. Salzberg M, Kirson E, Palti Y, Rochlitz C (2008) A pilot study with very low-intensity, intermediate-frequency electric fields in patients with locally advanced and/or metastatic solid tumors. Onkologie 31(7): 362-365. (Pubitemid 351967572)
17. Sonoda Y, Warita M, Suzuki T, Ozawa H, Fukuda Y, Funakoshi-Tago M, Kasahara T (2010) Proteolipid protein 2 is associated with melanoma metastasis. Oncol Rep 23: 371-376
18. Teschendorff AE, Caldas C (2008) A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer. Breast Cancer Res 10(4): R73.
19. Teschendorff AE, Miremadi A, Pinder SE, Ellis IO, Caldas C (2007) An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. Genome Biol 8(8): R157.
20. Thomas MB, Zhu AX (2005) Hepatocellular carcinoma: the need for progress. J Clin Oncol 23(13): 2892-2899 (Pubitemid 46224106)
21. Wang Z, Gerstein M, Snyder M (2009) RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10: 57-63