Cardioprotective effect of therapeutic hypothermia at 34°C against ischaemia/reperfusion injury mediated by PI3K and nitric oxide in a rat isolated heart model

Resuscitation

Volumn 83, Issue 2, 2012, Pages 238-242

  Mochizuki, Toshiaki ^a   Yu, Shuchun ^a   Katoh, Takasumi ^a   Aoki, Katsunori ^a   Sato, Shigehito ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cooling; Infarct size; Ischaemia reperfusion injury; Reactive oxygen species (ROS); Viability

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; HEART INFARCTION SIZE; HEART INJURY; HEART LEFT VENTRICLE INFARCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INDUCED HYPOTHERMIA; ISOLATED HEART; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TREATMENT OUTCOME;

ANIMALS; BODY TEMPERATURE; DISEASE MODELS, ANIMAL; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; HEART; HYPOTHERMIA, INDUCED; MALE; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3-KINASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84856472618     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2011.08.013     Document Type: Article

References (22)

1. Wachelder E.M., Moulaert V.R., van Heugten C., et al. Life after survival: long-term daily functioning and quality of life after an out-of-hospital cardiac arrest. Resuscitation 2009, 80:517-522.
2. Middelkamp W., Moulaert V.R., Verbunt J.A., et al. Life after survival: long-term daily life functioning and quality of life of patients with hypoxic brain injury as a result of a cardiac arrest. Clin Rehabil 2007, 21:425-431.
3. Gnanasekaran G. Epidemiology of depression in heart failure. Heart Fail Clin 2011, 7:1-10.
4. Maixner S.M., Struble L., Blazek M., et al. Later-life depression and heart failure. Heart Fail Clin 2011, 7:47-58.
5. Nolan J.P., Morley P.T., Hoek T.L.V., et al. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resuscitation 2003, 57:231-235.
6. Walters J.H., Morley P.T., Nolan J.P. The role of hypothermia in post-cardiac arrest patients with return of spontaneous circulation: a systematic review. Resuscitation 2011, 82:508-516.
7. Shao Z.-H., Chang W.-T., Chan K.C., et al. Hypothermia-induced cardioprotection using extended ischemia and early reperfusion cooling. Am J Physiol Heart Circ Physiol 2007, 292:H1995-H2003.
8. Hsu C.-Y., Huang C.-H., Chang W.-T., et al. Cardioprotective effect of therapeutic hypothermia for postresuscitation myocardial dysfunction. Shock 2009, 32:210-216.
9. Chenoune M., Lidouren F., Ghaleh B., et al. Rapid cooling of the heart with total liquid ventilation prevents transmural myocardial infarction following prolonged ischemia in rabbits. Resuscitation 2010, 81:359-362.
10. Shao Z.-H., Sharp W.W., Wojcik K.R., et al. Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants. Am J Physiol Heart Circ Physiol 2010, 298:H2164-H2173.
11. Vanden Hoek T.L., Shao Z., Li C., et al. Reperfusion injury on cardiac myocytes after simulated ischemia. Am J Physiol 1996, 270:H1334-H1341.
12. 2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury. Crit Care Med 2007, 35:1709-1716.
13. Pantos C., Mourouzis I., Cokkinos DV Myocardial ischemia. Basic concepts. Myocardial ischemia; from mechanisms to therapeutic potentials 2006, 11-76. Springer, New York. D.V. Cokkinos, C. Pantos, G. Heusch, H. Taegtmeyer (Eds.).
14. Mochizuki T., Sato S. Hypocapnia prolongs bradycardia induced by bupivacaine or levobupivacaine in isolated rat hearts. Can J Anaesth 2008, 55:836-846.
15. Yu S., Katoh T., Okada H., et al. Landiolol does not enhance the effect of ischemic preconditioning in isolated rat hearts. J Anesth 2010, 24:208-214.
16. Mimuro S., Katoh T., Suzuki A., et al. Deterioration of myocardial injury due to dexmedetomidine administration after myocardial ischaemia. Resuscitation 2010, 81:1714-1717.
17. Deakin C.D., Nolan J.P., Soar J., et al. European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support. Resuscitation 2010, 81:1305-1352.
18. Peberdy M.A., Callaway C.W., Neumar R.W., et al. Part 9: post-cardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010, 122:S768-S786.
19. Merchant R.M., Abella B.S., Peberdy M.A., et al. Therapeutic hypothermia after cardiac arrest: unintentional overcooling is common using ice packs and conventional cooling blankets. Crit Care Med 2006, 34:S490-S494.
20. Leary P.J., Rajasekaran S., Morrison R.R., et al. A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. Am J Physiol Heart Circ Physiol 2008, 294:H2775-H2784.
21. Vanhaesebroeck B., Leevers S.J., Ahmadi K., et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 2001, 70:535-602.
22. Yang X., Liu Y., Yang X.-M., et al. Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity. Basic Res Cardiol 2011, 106:421-430.