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Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
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Sakuishi, K, Apetoh, L., Sullivan, J. M., Bla-zar, B. R., Kuchroo, V. K, Anderson, A. C. (2010) Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore antitumor immunity. J. Exp. Med. 207, 2187-2194.
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Jin, H. T., Anderson, A. C, Tan, W. G., West, E. E., Ha, S. J., Araki, K, Freeman, G. J., Kuchroo, V. K., Ahmed, R. (2010) Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 107, 14733-14738.
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