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Volumn 35, Issue SUPPL. 1, 2012, Pages 21-27

Targeted therapy of soft tissue sarcomas

Author keywords

Epigenetic mechanisms; GIST; Soft tissue sarcoma; Targeted therapy; VEGF

Indexed keywords

IMATINIB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; PROTEIN TYROSINE KINASE INHIBITOR; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR;

EID: 84856456005     PISSN: 0378584X     EISSN: 14230240     Source Type: Journal    
DOI: 10.1159/0003349587     Document Type: Article
Times cited : (7)

References (56)
  • 1
    • 78650420363 scopus 로고    scopus 로고
    • Multimodality therapy concepts for soft tissue sarcomas
    • Wendtner CM, Delank S, Eich H: (Multimodality therapy concepts for soft tissue sarcomas). Internist (Berl) 2010;51:1388-96.
    • (2010) Internist (Berl) , vol.51 , pp. 1388-1396
    • Wendtner, C.M.1    Delank, S.2    Eich, H.3
  • 2
    • 34249723214 scopus 로고    scopus 로고
    • Opportunities for improving the therapeutic ratio for patients with sarcoma
    • DOI 10.1016/S1470-2045(07)70169-9, PII S1470204507701699
    • Wunder JS, Nielsen TO, Maki RG, O'Sullivan B, Alman BA: Opportunities for improving the therapeutic ratio for patients with sarcoma. Lancet Oncol 2007;8:513-24. (Pubitemid 46823060)
    • (2007) Lancet Oncology , vol.8 , Issue.6 , pp. 513-524
    • Wunder, J.S.1    Nielsen, T.O.2    Maki, R.G.3    O'Sullivan, B.4    Alman, B.A.5
  • 3
    • 0032471199 scopus 로고    scopus 로고
    • Retroperitoneal soft-tissue sarcoma: Analysis of 500 patients treated and followed at a single institution
    • DOI 10.1097/00000658-199809000-00008
    • Lewis JJ, Leung D, Woodruff JM, Brennan MF: Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann Surg 1998;228:355-65. (Pubitemid 30191698)
    • (1998) Annals of Surgery , vol.228 , Issue.3 , pp. 355-365
    • Lewis, J.J.1    Leung, D.2    Woodruff, J.M.3    Brennan, M.F.4
  • 5
    • 0029913782 scopus 로고    scopus 로고
    • Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities
    • Pisters PW, Leung DH, Woodruff J, Shi W, Brennan MF: Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 1996;14:1679-89. (Pubitemid 26134227)
    • (1996) Journal of Clinical Oncology , vol.14 , Issue.5 , pp. 1679-1689
    • Pisters, P.W.T.1    Leung, D.H.Y.2    Woodruff, J.3    Shi, W.4    Brennan, M.F.5
  • 8
    • 77953494126 scopus 로고    scopus 로고
    • Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: A randomised phase 3 multicentre study
    • Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem BC, et al.: Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet Oncol 2010; 11:561-70.
    • (2010) Lancet Oncol , vol.11 , pp. 561-570
    • Issels, R.D.1    Lindner, L.H.2    Verweij, J.3    Wust, P.4    Reichardt, P.5    Schem, B.C.6
  • 9
    • 0031566814 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: Meta-analysis of individual data Sarcoma Metaanalysis Collaboration
    • No authors listed: Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Metaanalysis Collaboration. Lancet 1997;350:1647-54.
    • (1997) Lancet , vol.350 , pp. 1647-1654
    • Authors Listed, N.1
  • 10
    • 71049134915 scopus 로고    scopus 로고
    • Perivascular epithelioid cell neoplasms: Pathology and pathogenesis
    • Folpe AL, Kwiatkowski DJ: Perivascular epithelioid cell neoplasms: pathology and pathogenesis. Hum Pathol 2010;41:1-15.
    • (2010) Hum Pathol , vol.41 , pp. 1-15
    • Folpe, A.L.1    Kwiatkowski, D.J.2
  • 12
    • 80051664152 scopus 로고    scopus 로고
    • Systemic therapy options for unresectable and metastatic chordomas
    • Stacchiotti S, Casali PG: Systemic therapy options for unresectable and metastatic chordomas. Curr Oncol Rep 2011;13:323-30.
    • (2011) Curr Oncol Rep , vol.13 , pp. 323-330
    • Stacchiotti, S.1    Casali, P.G.2
  • 17
    • 77954300616 scopus 로고    scopus 로고
    • Prognostic time dependence of deletions affecting codons 557 and/or 558 of KIT gene for relapse-free survival (RFS) in localized GIST: A Spanish Group for Sarcoma Research (GEIS) Study
    • Martin-Broto J, Gutierrez A, Garcia-del-Muro X, Lopez-Guerrero JA, Martinez-Trufero J, de Sande LM, et al.: Prognostic time dependence of deletions affecting codons 557 and/or 558 of KIT gene for relapse-free survival (RFS) in localized GIST: a Spanish Group for Sarcoma Research (GEIS) Study. Ann Oncol 2010;21:1552-7.
    • (2010) Ann Oncol , vol.21 , pp. 1552-7
    • Martin-Broto, J.1    Gutierrez, A.2    Garcia-Del-Muro, X.3    Lopez-Guerrero, J.A.4    Martinez-Trufero, J.5    De Sande, L.M.6
  • 19
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • DOI 10.1053/hupa.2002.124124
    • Heinrich MC, Rubin BP, Longley BJ, Fletcher JA: Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol 2002;33:484-95. (Pubitemid 34747867)
    • (2002) Human Pathology , vol.33 , Issue.5 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley B.Jack3    Fletcher, J.A.4
  • 21
    • 77949898532 scopus 로고    scopus 로고
    • Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: A meta-analysis of 1,640 patients
    • Gastrointestinal Stromal Tumor Meta-Analysis Group (MetaGIST): Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: a meta-analysis of 1,640 patients. J Clin Oncol 2010;28:1247-53.
    • (2010) J Clin Oncol , vol.28 , pp. 1247-53
  • 24
    • 62849096370 scopus 로고    scopus 로고
    • Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: A randomised, double-blind, placebo-controlled trial
    • Dematteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, et al.: Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet 2009;373:1097-104.
    • (2009) Lancet , vol.373 , pp. 1097-104
    • Dematteo, R.P.1    Ballman, K.V.2    Antonescu, C.R.3    Maki, R.G.4    Pisters, P.W.5    Demetri, G.D.6
  • 25
    • 80053465153 scopus 로고    scopus 로고
    • Twelve versus 36 months of adjuvant imatinib (IM) as treatment of operable GIST with a high risk of recurrence: Final results of a randomized trial (SSGXVIII/ AIO)
    • abstr LBA1
    • Joensuu H, Eriksson M, Hartmann J, Sundby Hall K, Schutte J, Reichardt A, Schlemmer M, et al.: Twelve versus 36 months of adjuvant imatinib (IM) as treatment of operable GIST with a high risk of recurrence: final results of a randomized trial (SSGXVIII/ AIO). J Clin Oncol 2011;29(suppl):abstr LBA1.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Joensuu, H.1    Eriksson, M.2    Hartmann, J.3    Sundby Hall, K.4    Schutte, J.5    Reichardt, A.6    Schlemmer, M.7
  • 27
    • 79251591976 scopus 로고    scopus 로고
    • Updating progress in sarcoma therapy with mTOR inhibitors
    • Blay JY: Updating progress in sarcoma therapy with mTOR inhibitors. Ann Oncol 2011;22:280-7.
    • (2011) Ann Oncol , vol.22 , pp. 280-287
    • Blay, J.Y.1
  • 28
    • 79960911022 scopus 로고    scopus 로고
    • Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma
    • Friedrichs N, Trautmann M, Endl E, Sievers E, Kindler D, Wurst P, et al.: Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma. Int J Cancer 2011;129:1564-75.
    • (2011) Int J Cancer , vol.129 , pp. 1564-1575
    • Friedrichs, N.1    Trautmann, M.2    Endl, E.3    Sievers, E.4    Kindler, D.5    Wurst, P.6
  • 29
    • 33847779638 scopus 로고    scopus 로고
    • Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: Emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma
    • Montaner S: Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma. Cell Cycle 2007;6:438-43. (Pubitemid 46393447)
    • (2007) Cell Cycle , vol.6 , Issue.4 , pp. 438-443
    • Montaner, S.1
  • 32
    • 79953176993 scopus 로고    scopus 로고
    • Ridaforolimus
    • No authors listed: Ridaforolimus. Drugs R D 2010;10:165-78.
    • (2010) Drugs R D , vol.10 , pp. 165-178
    • Authors Listed, N.1
  • 33
    • 80053944575 scopus 로고    scopus 로고
    • Antitumor activity of ridaforolimus and potential cell cycle determinants of sensitivity in sarcoma and endometrial cancer models
    • Squillace RM, Miller D, Cookson M, Wardwell SD, Moran L, Clapham D, et al.: Antitumor activity of ridaforolimus and potential cell cycle determinants of sensitivity in sarcoma and endometrial cancer models. Mol Cancer Ther 2011;10:1959-68.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1959-1968
    • Squillace, R.M.1    Miller, D.2    Cookson, M.3    Wardwell, S.D.4    Moran, L.5    Clapham, D.6
  • 34
    • 80054055727 scopus 로고    scopus 로고
    • Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT)
    • abstr 10005
    • Chawla SP, Blay J, Ray-Coquard IL, Le Cesne A, Staddon AP, et al.: Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT). J Clin Oncol 2011; 29(suppl):abstr 10005.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Chawla, S.P.1    Blay, J.2    Ray-Coquard, I.L.3    Le Cesne, A.4    Staddon, A.P.5
  • 35
    • 57149093206 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma
    • Friedrichs N, Kuchler J, Endl E, Koch A, Czerwitzki J, Wurst P, et al.: Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma. J Pathol 2008;216:428-39.
    • (2008) J Pathol , vol.216 , pp. 428-439
    • Friedrichs, N.1    Kuchler, J.2    Endl, E.3    Koch, A.4    Czerwitzki, J.5    Wurst, P.6
  • 36
    • 33244494390 scopus 로고    scopus 로고
    • IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1
    • DOI 10.1038/sj.onc.1209143, PII 1209143
    • Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S: IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Oncogene 2006;25:1042-52. (Pubitemid 43277012)
    • (2006) Oncogene , vol.25 , Issue.7 , pp. 1042-1052
    • Sun, Y.1    Gao, D.2    Liu, Y.3    Huang, J.4    Lessnick, S.5    Tanaka, S.6
  • 37
    • 0033179378 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor-1 receptor in synovial sarcoma: Association with an aggressive phenotype
    • Xie Y, Skytting B, Nilsson G, Brodin B, Larsson O: Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype. Cancer Res 1999;59:3588-91. (Pubitemid 29381857)
    • (1999) Cancer Research , vol.59 , Issue.15 , pp. 3588-3591
    • Xie, Y.1    Skytting, B.2    Nilsson, G.3    Brodin, B.4    Larsson, O.5
  • 38
    • 79951860072 scopus 로고    scopus 로고
    • Small is beautiful: Insulin-like growth factors and their role in growth, development, and cancer
    • Maki RG: Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J Clin Oncol 2010;28:4985-95.
    • (2010) J Clin Oncol , vol.28 , pp. 4985-4995
    • Maki, R.G.1
  • 39
    • 0035728324 scopus 로고    scopus 로고
    • Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein
    • DOI 10.1054/ghir.2001.0244
    • Ayalon D, Glaser T, Werner H: Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein. Growth Horm IGF Res 2001;11:289-97. (Pubitemid 34257726)
    • (2001) Growth Hormone and IGF Research , vol.11 , Issue.5 , pp. 289-297
    • Ayalon, D.1    Glaser, T.2    Werner, H.3
  • 40
    • 0025632981 scopus 로고
    • Insulin-like growth factor i expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation A potential autocrine growth factor
    • Yee D, Favoni RE, Lebovic GS, Lombana F, Powell DR, Reynolds CP, et al.: Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor. J Clin Invest 1990;86:1806-14.
    • (1990) J Clin Invest , vol.86 , pp. 1806-1814
    • Yee, D.1    Favoni, R.E.2    Lebovic, G.S.3    Lombana, F.4    Powell, D.R.5    Reynolds, C.P.6
  • 41
    • 33745212417 scopus 로고    scopus 로고
    • Insulin-like growth factor i receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor
    • Martins AS, Mackintosh C, Martin DH, Campos M, Hernandez T, Ordonez JL, et al.: Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor. Clin Cancer Res 2006; 12:3532-40.
    • (2006) Clin Cancer Res , vol.12 , pp. 3532-3540
    • Martins, A.S.1    MacKintosh, C.2    Martin, D.H.3    Campos, M.4    Hernandez, T.5    Ordonez, J.L.6
  • 43
    • 77953915105 scopus 로고    scopus 로고
    • Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/ solitary fibrous tumor
    • Park MS, Ravi V, Araujo DM: Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/ solitary fibrous tumor. Curr Opin Oncol 2010;22:351-5.
    • (2010) Curr Opin Oncol , vol.22 , pp. 351-355
    • Park, M.S.1    Ravi, V.2    Araujo, D.M.3
  • 44
    • 27244450145 scopus 로고    scopus 로고
    • Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas
    • D'Adamo DR, Anderson SE, Albritton K, Yamada J, Riedel E, Scheu K, et al.: Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J Clin Oncol 2005; 23:7135-42.
    • (2005) J Clin Oncol , vol.23 , pp. 7135-7142
    • D'Adamo, D.R.1    Anderson, S.E.2    Albritton, K.3    Yamada, J.4    Riedel, E.5    Scheu, K.6
  • 45
    • 79961219491 scopus 로고    scopus 로고
    • Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor
    • Park MS, Patel SR, Ludwig JA, Trent JC, Conrad CA, Lazar AJ, et al.: Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor. Cancer 2011; 117:4939-47.
    • (2011) Cancer , vol.117 , pp. 4939-4947
    • Park, M.S.1    Patel, S.R.2    Ludwig, J.A.3    Trent, J.C.4    Conrad, C.A.5    Lazar, A.J.6
  • 46
    • 67650312341 scopus 로고    scopus 로고
    • Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas
    • George S, Merriam P, Maki RG, Van den Abbeele AD, Yap JT, Akhurst T, et al.: Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas. J Clin Oncol 2009;27:3154-60.
    • (2009) J Clin Oncol , vol.27 , pp. 3154-3160
    • George, S.1    Merriam, P.2    Maki, R.G.3    Van Den Abbeele, A.D.4    Yap, J.T.5    Akhurst, T.6
  • 48
    • 67650337802 scopus 로고    scopus 로고
    • Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)
    • Sleijfer S, Ray-Coquard I, Papai Z, Le Cesne A, Scurr M, Schoffski P, et al.: Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol 2009;27:3126-32.
    • (2009) J Clin Oncol , vol.27 , pp. 3126-3132
    • Sleijfer, S.1    Ray-Coquard, I.2    Papai, Z.3    Le Cesne, A.4    Scurr, M.5    Schoffski, P.6
  • 49
    • 80355141438 scopus 로고    scopus 로고
    • PALETTE: A randomized, double-blind, phase III trial of pazopanib versus placebo in patients (pts) with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy -An EORTC STBSG Global Network Study (EORTC 62072)
    • abstr LBA10002
    • Van Der Graaf WT, Blay J, Chawla SP, Kim D, Bui Nguyen B, et al.:. PALETTE: A randomized, double-blind, phase III trial of pazopanib versus placebo in patients (pts) with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy -an EORTC STBSG Global Network Study (EORTC 62072). J Clin Oncol 2011;29(suppl):abstr LBA10002.
    • J Clin Oncol 2011 , vol.29 , Issue.SUPPL.
    • Van Der Graaf, W.T.1    Blay, J.2    Chawla, S.P.3    Kim, D.4    Bui Nguyen, B.5
  • 50
    • 80052850859 scopus 로고    scopus 로고
    • Reactivation of p53 by inhibiting Mdm2 E3 ligase: A novel antitumor approach
    • Epub ahead of print
    • Di J, Zhang Y, Zheng J Reactivation of p53 by inhibiting Mdm2 E3 ligase: a novel antitumor approach. Curr Cancer Drug Targets 2011;Epub ahead of print.
    • (2011) Curr Cancer Drug Targets
    • Di, J.1    Zhang, Y.2    Zheng, J.3
  • 51
    • 77649256273 scopus 로고    scopus 로고
    • Restoring p53 function in cancer: Novel therapeutic approaches for applying the brakes to tumorigenesis
    • Di Cintio A, Di Gennaro E, Budillon A: Restoring p53 function in cancer: novel therapeutic approaches for applying the brakes to tumorigenesis. Recent Pat Anticancer Drug Discov 2010;5:1-13.
    • (2010) Recent Pat Anticancer Drug Discov , vol.5 , pp. 1-13
    • Di Cintio, A.1    Di Gennaro, E.2    Budillon, A.3
  • 52
    • 77951224332 scopus 로고    scopus 로고
    • Identification and characterization of the first small molecule inhibitor of MDMX
    • Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, et al.: Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem 2010;285:10786-96.
    • (2010) J Biol Chem , vol.285 , pp. 10786-96
    • Reed, D.1    Shen, Y.2    Shelat, A.A.3    Arnold, L.A.4    Ferreira, A.M.5    Zhu, F.6
  • 54
    • 19444376494 scopus 로고    scopus 로고
    • Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo
    • DOI 10.1016/j.canlet.2004.10.030, PII S0304383504008122
    • Ito T, Ouchida M, Morimoto Y, Yoshida A, Jitsumori Y, Ozaki T, et al.: Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo. Cancer Lett 2005;224:311-9. (Pubitemid 40725851)
    • (2005) Cancer Letters , vol.224 , Issue.2 , pp. 311-319
    • Ito, T.1    Ouchida, M.2    Morimoto, Y.3    Yoshida, A.4    Jitsumori, Y.5    Ozaki, T.6    Sonobe, H.7    Inoue, H.8    Shimizu, K.9


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