In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probes

Journal of the American College of Cardiology

Volumn 59, Issue 6, 2012, Pages 616-626

  Briley Saebo, Karen C ^a   Nguyen, Tuyen Hoang ^a   Saeboe, Alexander M ^a   Cho, Young Seok ^b,d   Ryu, Sung Kee ^b,e   Volkava, Eugenia ^a   Dickson, Stephen ^a   Leibundgut, Gregor ^b,c   Weisner, Philipp ^c   Green, Simone ^b   Casanada, Florence ^b   Miller, Yury I ^c   Shaw, Walter ^f   Witztum, Joseph L ^c   Fayad, Zahi A ^a   Tsimikas, Sotirios ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Seoul National University   (South Korea)

^e Eulji University   (South Korea)

^f Avanti Polar Lipids   (United States)

Author keywords

atherosclerosis; inflammation; molecular imaging; MRI; oxidation

Indexed keywords

APOLIPOPROTEIN E; EPITOPE; GADOLINIUM; LOW DENSITY LIPOPROTEIN RECEPTOR; MALONALDEHYDE; MANGANESE; MONOCLONAL ANTIBODY MDA2 GADOLINIUM; MONOCLONAL ANTIBODY MDA2 MANGANESE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; RHODAMINE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY IK17 GADOLINIUM; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY IK17 MANGANESE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BIOCOMPATIBILITY; CONFOCAL MICROSCOPY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SYNTHESIS; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MICELLE; MOLECULAR PROBE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; BIOCOMPATIBLE MATERIALS; DISEASE MODELS, ANIMAL; EPITOPES; LIPOPROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MANGANESE; MICE; MICE, KNOCKOUT; MICELLES; OXIDATION-REDUCTION; PLAQUE, ATHEROSCLEROTIC; REPRODUCIBILITY OF RESULTS;

EID: 84856419706     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.10.881     Document Type: Article

References (34)

1. R. Virmani, A.P. Burke, A. Farb, F.D. Kolodgie Pathology of the vulnerable plaque J Am Coll Cardiol 47 2006 C13 C18
2. S. Tsimikas, E.S. Brilakis, E.R. Miller Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease N Engl J Med 353 2005 46 57 (Pubitemid 41007806)
3. S. Tsimikas, Y.I. Miller Oxidative modification of lipoproteins: mechanisms, role in inflammation and potential clinical applications in cardiovascular disease Curr Pharma Des 17 2011 27 37
4. S. Kiechl, J. Willeit, M. Mayr Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study Arterioscler Thromb Vasc Biol 27 2007 1788 1795 (Pubitemid 47207175)
5. K.C. Briley-Saebo, P.X. Shaw, W.J. Mulder Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes Circulation 117 2008 3206 3215
6. K.C. Briley-Saebo, Y.S. Cho, P.X. Shaw Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes J Am Coll Cardiol 57 2011 337 347
7. M.E. Bartolini, J. Pekar, D.R. Chettle An investigation of the toxicity of gadolinium based MRI contrast agents using neutron activation analysis Magn Reson Imaging 21 2003 541 544 (Pubitemid 36899087)
8. M. Ide, M. Kuwamura, T. Kotani, O. Sawamoto, J. Yamate Effects of gadolinium chloride (GdCl(3)) on the appearance of macrophage populations and fibrogenesis in thioacetamide-induced rat hepatic lesions J Comp Pathol 133 2005 92 102 (Pubitemid 41150166)
9. M.A. Sieber, T. Steger-Hartmann, P. Lengsfeld, H. Pietsch Gadolinium-based contrast agents and NSF: evidence from animal experience J Magn Reson Imaging 30 2009 1268 1276
10. G. Eser, A. Karabacakoglu, S. Karakose, C. Eser, E. Kayacetin Mangafodipir trisodium-enhanced magnetic resonance imaging for evaluation of pancreatic mass and mass-like lesions World J Gastroenterol 12 2006 1603 1606
11. K.G. Toft, S.O. Hustvedt, D. Grant, G.A. Friisk, T. Skotland Metabolism of mangafodipir trisodium (MnDPDP), a new contrast medium for magnetic resonance imaging, in beagle dogs Eur J Drug Metab Pharmacokinet 22 1997 65 72 (Pubitemid 27254326)
12. W. Nordhoy, H.W. Anthonsen, M. Bruvold Intracellular manganese ions provide strong T1 relaxation in rat myocardium Magn Reson Med 52 2004 506 514 (Pubitemid 39108961)
13. W. Nordhoy, H.W. Anthonsen, M. Bruvold, P. Jynge, J. Krane, H. Brurok Manganese ions as intracellular contrast agents: proton relaxation and calcium interactions in rat myocardium NMR Biomed 16 2003 82 95 (Pubitemid 36582227)
14. S.H. Koenig, C. Baglin, R.D. Brown Magnetic-field dependence of solvent proton relaxation induced by Gd3+ and Mn2+ complexes Magn Reson Med 1 1984 496 501 (Pubitemid 15117610)
15. S. Tsimikas, W. Palinski, S.E. Halpern, D.W. Yeung, L.K. Curtiss, J.L. Witztum Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo J Nucl Cardiol 6 1999 41 53 (Pubitemid 29112595)
16. S. Tsimikas, B.P. Shortal, J.L. Witztum, W. Palinski In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression Arterioscler Thromb Vasc Biol 20 2000 689 697 (Pubitemid 30151682)
17. J.H. Jung, K. An, O.B. Kwon, H.S. Kim, J.H. Kim Pathway-specific alteration of synaptic plasticity in Tg2576 mice Mol Cells 32 2011 19720
18. R. Dei, A. Takeda, H. Niwa Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease Acta Neuropathol 104 2002 113 122 (Pubitemid 36075368)
19. R.B. Lauffer, A.C. Vincent, S. Padmanabhan Hepatobiliary MR contrast agents: 5-substituted iron-EHPG derivatives Magn Reson Med 4 1987 582 590 (Pubitemid 17112155)
20. W.J. Mulder, R. Koole, R.J. Brandwijk Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe Nano Lett 6 2006 1 6 (Pubitemid 43166093)
21. R.B. Lauffer Paramagnetic metal-complexes as water proton relaxation agents for NMR imaging: theory and design Chem Rev 87 1987 901 927
22. M. Bruvold, W. Nordhoy, H.W. Anthonsen, H. Brurok, P. Jynge Manganese-calcium interactions with contrast media for cardiac magnetic resonance imaging: a study of manganese chloride supplemented with calcium gluconate in isolated Guinea pig hearts Invest Radiol 40 2005 117 125 (Pubitemid 40289438)
23. F. Rovetta, S. Catalani, N. Steimberg Organ-specific manganese toxicity: a comparative in vitro study on five cellular models exposed to MnCl(2) Toxicol In Vitro 21 2006 284 292 (Pubitemid 46205077)
24. K.N. Khan, J.M. Andress, P.F. Smith Toxicity of subacute intravenous manganese chloride administration in beagle dogs Toxicol Pathol 25 1997 344 350 (Pubitemid 27364933)
25. P. Rongved, J.O. Karlson, K. Briley Saebo Amersham assignee Magnetic Resonance Imaging Method and Compounds For Use in the Method US patent US2006/023529A1 2006
26. D. Zhu, X.L. Lu, P.A. Hardy, M. Leggas, M. Jay Nanotemplate-engineered nanoparticles containing gadolinium for magnetic resonance imaging of tumors Invest Radiol 43 2008 129 140
27. J.C. Weinreb, A.K. Abu-Alfa Gadolinium-based contrast agents and nephrogenic systemic fibrosis: why did it happen and what have we learned? J Magn Reson Imaging 30 2009 1236 1239
28. L.E. Larsen, D. Grant General toxicology of MnDPDP Acta radiologica 38 1997 770 779 (Pubitemid 127453096)
29. M. Torzewski, P.X. Shaw, K.R. Han Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization Arterioscler Thromb Vasc Biol 24 2004 2307 2312 (Pubitemid 39658034)
30. A. Spencer, S. Wilson, E. Harpur Gadolinium chloride toxicity in the mouse Hum Exp Toxicol 17 1998 633 637 (Pubitemid 28542579)
31. K.C. Briley-Saebo, Y.S. Cho, S. Tsimikas Imaging of oxidation-specific epitopes in atherosclerosis and macrophage-rich vulnerable plaques Curr Cardiovasc Imaging Rep 4 2011 4 16
32. T.Y. Tang, K.H. Muller, M.J. Graves Iron oxide particles for atheroma imaging Arterioscler Thromb Vasc Biol 29 2009 1001 1008
33. R.A. Trivedi, M.J. Graves In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI JM UK-I Stroke 35 2004 1631 1635 (Pubitemid 38823638)
34. A. Ravandi, R. Harkewicz, G. Leibundgut Identification of oxidized phospholipids and cholesteryl esters in embolic protection devices post percutaneous coronary, carotid and peripheral interventions in humans Arterioscler Thromb Vasc Biol P385 2011