The discovery of an antiparkinsonian drug, zonisamide

Clinical Neurology

Volumn 50, Issue 11, 2010, Pages 780-782

  Murata, Miho ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

Dopamine synthesis; Neruprotection; Parkinson disease; Zonisamide

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); CALCIUM CHANNEL T TYPE; DOPAMINE; MESSENGER RNA; TYROSINE 3 MONOOXYGENASE; ZONISAMIDE;

CONFERENCE PAPER; CORPUS STRIATUM; DISEASE COURSE; DOPAMINE METABOLISM; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; EXPERIMENTAL MODEL; GENE EXPRESSION; GENETIC ASSOCIATION; GLIA; HUMAN; JAPAN; MOTOR PERFORMANCE; NERVE CELL; NEUROPROTECTION; PARKINSON DISEASE; PROTEIN EXPRESSION;

ANIMALS; ANTIPARKINSON AGENTS; CALCIUM CHANNELS, T-TYPE; CLINICAL TRIALS AS TOPIC; CORPUS STRIATUM; DOPAMINE; DRUG APPROVAL; DRUG DISCOVERY; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INDIVIDUALIZED MEDICINE; ISOXAZOLES; JAPAN; MONOAMINE OXIDASE INHIBITORS; NEUROPROTECTIVE AGENTS; TYROSINE 3-MONOOXYGENASE;

EID: 84856404610     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: 10.5692/clinicalneurol.50.780     Document Type: Conference Paper

References (10)

1. Murata M, Horiuchi E, Kanazawa I. Zonisamide has beneficial effects on Parkinson's disease patients. Neurosci Res 2001;41:397-399. (Pubitemid 33733759)
2. Okada M, Kaneko S, Hirano T, et al. Effects of zonisamide on dopaminergic system. Epilepsy Res 1995;22:193-205.
3. Matsumoto K, Miyazaki H, Fujii T, et al. Absorption, distribution and excretion of 3-(sulfamoyl [14C] methyl)-l, 2-benziosoxazole (AD-810) in rats, dogs and monkeys and of AD-810 in Men. Arzneimittelforschung 1983:33561-968.
4. Murata M, Hasegawa K, Kanazawa I, The Japan Zonisamide on PD Study Group. Zonisamide improves motor function in Parkinson disease. A randomized, doubleblind study. Neurology 2007;68:45-50. (Pubitemid 46058551)
5. Brain Nerve 2009; 61:464472.
6. Murata M. Novel therapeutic effects of the anticonvulsant, zonisamide, on Parkinson's disease. Curr Pharmaceu Design 2004;10:687-693. (Pubitemid 38292396)
7. Yamamura S, Ohoyama K, Nagase H, et al. Zonisamide enhances delta receptor-associated neurotransmitter release in striato-pallidal pathway. Neuropharmacology 2009;57:322-331.
8. Asanuma M, Miyazaki I, Diaz-Corrales FJ, et al. Neuro-protective effects of zonisamide target astrocyte. Ann Neurol 2010;67:239-249.
9. Asanuma M, Miyazaki I, Diaz-Corrales FJ, et al. Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation. Neurosci Res 2008;60: 106-113.
10. Kawajiri S, Machida Y, Saiki S, et al. Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. Neurosci Lett 2010;481:88-91.