Worldwide variations in EGFR somatic mutations: A challenge for personalized medicine

Diagnostic Pathology

Volumn 7, Issue 1, 2012, Pages

  Lamy, Pierre Jean ^a   Jacot, William ^a  

^a CRLC Val d'Aurelle Paul Lamarque   (France)

Author keywords

Activating mutations; Breast cancer; Egfr; Geographic variations; Triple negative

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

BREAST TUMOR; CARCINOMA; FEMALE; GENE DOSAGE; GENETICS; HUMAN; MUTATION; NOTE;

BREAST NEOPLASMS; CARCINOMA; FEMALE; GENE DOSAGE; HUMANS; MUTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84856400490     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-7-13     Document Type: Note

References (11)

1. Lv N, Xie X, Ge Q, Lin S, Wang X, Kong Y, Shi H, Wei W. Epidermal growth factor receptor in breast carcinoma: association between gene copy number and mutations. Diagn Pathol 2011, 6(1):118. 10.1186/1746-1596-6-118, 3248849, 22132735.
2. Teng YH, Tan WJ, Thike AA, Cheok PY, Tse GM, Wong NS, Yip GW, Bay BH, Tan PH. Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy. Breast Cancer Res 2011, 13(2):R35. 10.1186/bcr2857, 3219198, 21457545.
3. Jacot W, Lopez-Crapez E, Thezenas S, Senal R, Fina F, Bibeau F, Romieu G, Lamy P-J. Lack of EGFR activating mutations in European patients with triple negative breast cancer could emphasize geographic and ethnic variations in breast cancer mutation profiles. Breast Cancer Research 2011, 13(6):R133. 10.1186/bcr3079, 22192147.
4. Bhargava R, Gerald WL, Li AR, Pan Q, Lal P, Ladanyi M, Chen B. EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Mod Pathol 2005, 18(8):1027-1033. 10.1038/modpathol.3800438, 15920544.
5. Reis-Filho JS, Milanezi F, Carvalho S, Simpson PT, Steele D, Savage K, Lambros MB, Pereira EM, Nesland JM, Lakhani SR, Schmitt FC. Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis. Breast Cancer Res 2005, 7(6):R1028-1035. 10.1186/bcr1341, 1410747, 16280056.
6. Generali D, Leek R, Fox SB, Moore JW, Taylor C, Chambers P, Harris AL. EGFR mutations in exons 18-21 in sporadic breast cancer. Ann Oncol 2007, 18(1):203-205.
7. Toyama T, Yamashita H, Kondo N, Okuda K, Takahashi S, Sasaki H, Sugiura H, Iwase H, Fujii Y. Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers. BMC Cancer 2008, 8:309. 10.1186/1471-2407-8-309, 2612006, 18950515.
8. Broet P, Dalmasso C, Tan EH, Alifano M, Zhang S, Wu J, Lee MH, Regnard JF, Lim D, Koong HN, et al. Genomic profiles specific to patient ethnicity in lung adenocarcinoma. Clin Cancer Res 2011, 17(11):3542-3550. 10.1158/1078-0432.CCR-10-2185, 21521776.
9. Fukumoto K, Usami N, Okasaka T, Kawaguchi K, Okagawa T, Suzuki H, Yokoi K. Late breast metastasis from resected lung cancer diagnosed by epidermal growth factor receptor gene mutation. Lung Cancer 74(2):352-353.
10. Marquez-Garban DC, Mah V, Alavi M, Maresh EL, Chen HW, Bagryanova L, Horvath S, Chia D, Garon E, Goodglick L, Pietras RJ. Progesterone and estrogen receptor expression and activity in human non-small cell lung cancer. Steroids 2011, 76(9):910-920.
11. Liu L, Shao X, Gao W, Bai J, Wang R, Huang P, Yin Y, Liu P, Shu Y. The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: a meta-analysis of published data. J Thorac Oncol 2010, 5(12):1922-1932. 10.1097/JTO.0b013e3181f26266, 21155183.