Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile

Life Sciences

Volumn 90, Issue 7-8, 2012, Pages 301-305

  Gavaldà, Amadeu ^a   Gras, Jordi ^a   Llupià, Josep ^a   Aubets, Jordi ^b   Beleta, Jorge ^a   Llenas, Jesús ^a  

^a Laboratorios Almirall SA ^*  (Spain)

^b R and D Centre   (Spain)

Author keywords

Aclidinium; Inhaled COPD treatment; Long acting muscarinic antagonist; Low plasma exposure; Renal safety; Urinary safety

Indexed keywords

ACLIDINIUM BROMIDE; IPRATROPIUM BROMIDE; TIOTROPIUM BROMIDE;

ANIMAL EXPERIMENT; ARTICLE; BLADDER PRESSURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; ELECTROLYTE EXCRETION; EXPERIMENTAL DOG; EXPERIMENTAL PIG; FEMALE; KIDNEY FUNCTION; MALE; MICTURITION CYSTOURETHROGRAPHY; NONHUMAN; RAT; RESIDUAL URINE; URINARY EXCRETION;

ANIMALS; DOGS; FEMALE; GUINEA PIGS; KIDNEY; KIDNEY FUNCTION TESTS; MALE; MUSCARINIC ANTAGONISTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RATS; RATS, WISTAR; SCOPOLAMINE DERIVATIVES; TIME FACTORS; TROPANES;

ANIMALIA; CANIS FAMILIARIS; CAVIA; RATTUS; RATTUS NORVEGICUS;

EID: 84856392646     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.12.002     Document Type: Article

References (22)

1. P.J. Barnes The role of anticholinergics in chronic obstructive pulmonary disease Am J Med 117 Suppl 12A 2004 24S 32S
2. Boehringer Ingelheim International GmbH. Atrovent HFA (ipratropium bromide HFA) inhalation aerosol package insert. 2008a.
3. Boehringer Ingelheim International GmbH. Spiriva HandiHaler (tiotropium bromide inhalation powder) package insert. 2008b.
4. P. Chanez, P.S. Burge, R. Dahl, J. Creemers, A. Chuchalin, and R. Lamarca Aclidinium bromide provides long-acting bronchodilation in patients with COPD Pulm Pharmacol Ther 23 2010 15 21
5. A.E. Colletti, H.W. Vogl, T. Rahe, and E.J. Zambraski Effects of acetaminophen and ibuprofen on renal function in anesthetized normal and sodium-depleted dogs J Appl Physiol 86 1999 592 597 (Pubitemid 29075812)
6. B. Disse, R. Reichl, G. Speck, W. Traunecker, K.L. Ludwig Rominger, and R. Hammer Ba 679 BR, a novel long-acting anticholinergic bronchodilator Life Sci 52 1993 537 544
7. A. Gavaldà, M. Miralpeix, I. Ramos, R. Otal, C. Carreño, and M. Viñals Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile J Pharmacol Exp Ther 331 2009 740 751
8. A. Gericke, J.J. Sniatecki, V.G. Mayer, E. Goloborodko, A. Patzak, and J. Wess Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice Am J Physiol Heart Circ Physiol 300 2011 H1602 H1608
9. J. Gras, A. Gavaldà, and J. Llenas The preclinical cardiovascular safety profile of aclidinium bromide, a novel long-acting anticholinergic drug Am J Respir Crit Care Med 177 2008 A-654 (Abstract issue.)
10. M.S. Jaakkola Smoke and dust get in your eyes: what does it mean in the workplace? Thorax 64 2009 1 2
11. J.M. Jansat, R. Lamarca, G. de Miquel, A. Schrodter, B. Miletzki, and M. Gurniak Safety and pharmacokinetics of multiple doses of aclidinium bromide, a novel long-acting muscarinic antagonist for the treatment of chronic obstructive pulmonary disease, in healthy participants J Clin Pharmacol 49 2009 1239 1246
12. G.F. Joos Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease Expert Opin Investig Drugs 19 2010 257 264
13. G.F. Joos, V.J. Schelfhout, R.A. Pauwels, F. Kanniess, H. Magnussen, and R. Lamarca Bronchodilatory effects of aclidinium bromide, a long-acting muscarinic antagonist, in COPD patients Respir Med 104 2010 865 872
14. S. Kesten, M. Jara, C. Wentworth, and S. Lanes Pooled clinical trial analysis of tiotropium safety Chest 130 2006 1695 1703 (Pubitemid 46033421)
15. A. Kunze, J. Neuhaus, and J.U. Stolzenburg Quantitative immunohistochemical study of the innervation of the guinea-pig lower urinary tract BJU Int 98 2006 424 429
16. A. Lokke, P. Lange, H. Scharling, P. Fabricius, and J. Vestbo Developing COPD: a 25 year follow up study of the general population Thorax 61 2006 935 939 (Pubitemid 44787161)
17. A.R. Modiri, P. Alberts, and P.G. Gillberg Effect of muscarinic antagonists on micturition pressure measured by cystometry in normal, conscious rats Urology 59 2002 963 968 (Pubitemid 34522201)
18. J.L. Montero, F. Anton, M. Vinals, J. Gras, A. Galvadà, and J. Llenas Effect of aclidinium bromide, a novel long-acting anticholinergic, on salivation, colonic motility and faecal output in different animal models Eur Respir J 32 Suppl 52 2008 3637
19. S. Sentellas, I. Ramos, J. Alberti, M. Salva, F. Anton, and M. Miralpeix Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites Eur J Pharm Sci 39 2010 283 290
20. A. Stephenson, D. Seitz, C.M. Bell, A. Gruneir, A.S. Gershon, and P.C. Austin Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease: a population-based study Arch Intern Med 171 2011 914 920
21. D. Tashkin Tiotropium in chronic obstructive pulmonary disease N Engl J Med 360 2009 185 187
22. R.D. Walters, G. McMurray, and A.F. Brading Comparison of the urethral properties of the female guinea pig and rat Neurourol Urodyn 25 2006 62 69 (Pubitemid 43050210)