An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positron emission tomography imaging of glial activation

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Shimazawa, Masamitsu ^a   Ito, Yasushi ^a   Inokuchi, Yuta ^a   Yamanaka, Hajime ^b   Nakanishi, Tomohiro ^a   Hayashi, Takuya ^b   Ji, Bin ^c   Higuchi, Makoto ^c   Suhara, Tetsuya ^c   Imamura, Kazuyuki ^d   Araie, Makoto ^e   Watanabe, Yasuyoshi ^b   Onoe, Hirotaka ^b   Hara, Hideaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^d MAEBASHI INSTITUTE OF TECHNOLOGY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BENZODIAZEPINE RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; PERIPHERAL TYPE BENZODIAZEPINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE SEVERITY; EYE PHOTOGRAPHY; GLAUCOMA; HISTOLOGY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTRAOCULAR HYPERTENSION; LATERAL GENICULATE NUCLEUS; MACACA FASCICULARIS; MICROGLIA; NERVE DEGENERATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN LOCALIZATION; ANIMAL; DISEASE MODEL; EVALUATION; GENICULATE BODY; GLIA; HUMAN; INTRAOCULAR PRESSURE; LOW LEVEL LASER THERAPY; METABOLISM; OPTIC NERVE DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SCINTISCANNING; TREATMENT OUTCOME;

MACACA FASCICULARIS;

ANIMALS; DISEASE MODELS, ANIMAL; GENICULATE BODIES; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; LASER THERAPY; MACACA FASCICULARIS; NERVE DEGENERATION; NEUROGLIA; OCULAR HYPERTENSION; OPTIC NERVE DISEASES; POSITRON-EMISSION TOMOGRAPHY; TREATMENT OUTCOME;

EID: 84856388781     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030526     Document Type: Article

References (30)

1. Ito Y, Shimazawa M, Chen YN, Tsuruma K, Yamashima T, et al. (2009) Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys. Exp Eye Res 89: 246-255.
2. Weber AJ, Chen H, Hubbard WC, Kaufman PL, (2000) Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest Ophthalmol Vis Sci 41: 1370-1379.
3. Yücel YH, Zhang Q, Gupta N, Kaufman PL, Weinreb RN, (2000) Loss of neurons in magnocellular and parvocellular layers of the lateral geniculate nucleus in glaucoma. Arch Ophthalmol 118: 378-384.
4. Yücel YH, Zhang Q, Weinreb RN, Kaufman PL, Gupta N, (2001) Atrophy of relay neurons in magno- and parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Invest Ophthalmol Vis Sci 42: 3216-3222.
5. Gupta N, Ang LC, Noel de Tilly L, Bidaisee L, Yücel YH, (2006) Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol 90: 674-678.
6. Gupta N, Greenberg G, de Tilly LN, Gray B, Polemidiotis M, et al. (2009) Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging. Br J Ophthalmol 93: 56-60.
7. Sasaoka M, Nakamura K, Shimazawa M, Ito Y, Araie M, et al. (2008) Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model. Exp Eye Res 86: 770-782.
8. Imamura K, Onoe H, Shimazawa M, Nozaki S, Wada Y, et al. (2009) Molecular imaging reveals unique degenerative changes in experimental glaucoma. Neuroreport 20: 139-144.
9. Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, et al. (2006) Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 27: 402-409.
10. Anholt RR, Pedersen PL, De Souza EB, Snyder SH, (1986) The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J Biol Chem 261: 576-583.
11. Benavides J, Guilloux F, Rufat P, Uzan A, Renault C, et al. (1984) In vivo labelling in several rat tissues of 'peripheral type' benzodiazepine binding sites. Eur J Pharmacol 99: 1-7.
12. Vowinckel E, Reutens D, Becher B, Verge G, Evans A, et al. (1997) PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res 50: 345-353.
13. Chen MK, Baidoo K, Verina T, Guilarte TR, (2004) Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain 127: 1379-1392.
14. Quigley HA, Hohman RM, (1983) Laser energy levels for trabecular meshwork damage in the primate eye. Invest Ophthalmol Vis Sci 24: 1305-1307.
15. Shimazawa M, Tomita G, Taniguchi T, Sasaoka M, Hara H, et al. (2006) Morphometric evaluation of changes with time in optic disc structure and thickness of retinal nerve fibre layer in chronic ocular hypertensive monkeys. Exp Eye Res 82: 427-440.
16. Shah F, Hume SP, Pike VW, Ashworth S, McDermott J, (1994) Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol 21: 573-581.
17. Lammertsma AA, Hume SP, (1996) Simplified reference tissue model for PET receptor studies. Neuroimage 4: 153-158.
18. Sanchez RM, Dunkelberger GR, Quigley HA, (1986) The number and diameter distribution of axons in the monkey optic nerve. Invest Ophthalmol Vis Sci 27: 1342-1350.
19. Whitmore AV, Libby RT, John SW, (2005) Glaucoma: thinking in new ways-a role for autonomous axonal self-destruction and other compartmentalised processes? Prog Retin Eye Res 24: 639-662.
20. Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, et al. (2007) Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 179: 1523-1537.
21. Kerrigan LA, Zack DJ, Quigley HA, Smith SD, Pease ME, (1997) TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch Ophthalmol 115: 1031-1035.
22. Quigley HA, Nickells RW, Kerrigan LA, Pease ME, Thibault DJ, et al. (1995) Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci 36: 774-786.
23. McGeer PL, Schwab C, Parent A, Doudet D, (2003) Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Ann Neurol 54: 599-604.
24. Lam D, Jim J, To E, Rasmussen C, Kaufman PL, et al. (2009) Astrocyte and microglial activation in the lateral geniculate nucleus and visual cortex of glaucomatous and optic nerve transected primates. Mol Vis 15: 2217-2229.
25. Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkheimer F, et al. (2000) The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123 (Pt 11): 2321-2337.
26. Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, et al. (2001) In-vivo measurement of activated microglia in dementia. Lancet 358: 461-467.
27. Gerhard A, Pavese N, Hotton G, Turkheimer F, Es M, et al. (2006) In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 21: 404-412.
28. Pavese N, Gerhard A, Tai YF, Ho AK, Turkheimer F, et al. (2006) Microglial activation correlates with severity in Huntington disease: a clinical and PET study. Neurology 66: 1638-1643.
29. Duncan RO, Sample PA, Weinreb RN, Bowd C, Zangwill LM, (2007) Retinotopic organization of primary visual cortex in glaucoma: a method for comparing cortical function with damage to the optic disk. Invest Ophthalmol Vis Sci 48: 733-744.
30. Qing G, Zhang S, Wang B, Wang N, (2010) Functional MRI signal changes in primary visual cortex corresponding to the central normal visual field of patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci 51: 4627-4634.