Pharmacodynamic Effects of Intravenous Alcohol on Hepatic and Gonadal Hormones: Influence of Age and Sex

Alcoholism: Clinical and Experimental Research

Volumn 36, Issue 2, 2012, Pages 207-213

  Vatsalya, Vatsalya ^a   Issa, Julnar E ^a   Hommer, Daniel W ^a   Ramchandani, Vijay A ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Age; Alcohol; Estradiol; Growth Hormone; IGF 1; Sex; Testosterone

Indexed keywords

ALCOHOL; ESTRADIOL; GROWTH HORMONE; PLACEBO; SEX HORMONE; SOMATOMEDIN C; TESTOSTERONE;

ADULT; AGE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMALE; HORMONAL REGULATION; HUMAN; MALE; NORMAL HUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SINGLE BLIND PROCEDURE; STEADY STATE; TESTOSTERONE BLOOD LEVEL;

ADULT; AGED; AGING; BREATH TESTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DATA INTERPRETATION, STATISTICAL; ESTRADIOL; ETHANOL; FEMALE; GONADAL HORMONES; HUMAN GROWTH HORMONE; HUMANS; INJECTIONS, INTRAVENOUS; INSULIN-LIKE GROWTH FACTOR I; LIVER; MALE; MIDDLE AGED; OVARY; SEX CHARACTERISTICS; SINGLE-BLIND METHOD; TESTIS; TESTOSTERONE; YOUNG ADULT;

EID: 84856386181     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2011.01600.x     Document Type: Article

References (37)

1. Borski RJ, Tsai W, DeMott-Friberg R, Bakan AL (1996) Regulation of somatic growth and somatrotropic axis by gonadal steroids: primary effect on insulin-like growth factor I gene expression and secretion. J Endocrinol137:3253-3259.
2. Breese CR, Ingram RL, Sonntag WE (1991) Influence of age and long-term dietary restriction on plasma insulin-like growth factor (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J Gerontol46:B180-B187.
3. Breese CR, Sonntag WE (1995) Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats. Alcohol Clin Exp Res19:867-873.
4. Bullock J, Boyle J, Wang MB (2001) Pituitary gland (the hypophysis), in Physiology, 4th edn (Nieginski EA ed), pp 579-590. Lippincott Williams & Wilkins, Philadelphia.
5. Chernausek SD, Underwood LE, Utiger RD, Vanwyk JJ (1983) Growth hormone secretion and plasma somatomedin-C in primary hypothyroidism. J Clin Endocrinol19:337-344.
6. Ellingboe J (1987) Acute effects of ethanol on sex hormones in non-alcoholic men and women. Alcohol Alcohol Suppl1:109-116.
7. Frantz AG, Rabkin MT (1965) Effects of estrogen and sex difference on secretion of human growth hormone. J Clin Endocrinol Metab25:1470-1480.
8. Goodman-Gruen D, Barrett-Connor E (1996) Effect of replacement estrogen on insulin-like growth factor-1 in postmenopausal women: the Rancho Bernardo Study. J Clin Endocrinol Metab81:4268-4271.
9. Gordon GG, Altman K, Southern AL, Rubin E, Lieber CS (1976) Effect of alcohol (ethanol) on sex-hormone metabolism in normal men. N Engl J Med295:793-797.
10. Gruenewald DA, Matsumoto AM (2003) Testosterone supplementation therapy for older men: potential benefits and risks. J Am Geriatr Soc51:101-115.
11. Ho KY, Evans WS, Blizzard RM, Veldhuis JD, Merriam GR, Samojlik E, Furlanetto R, Rogol AD, Kaiser DL, Thorner MO (1987) Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab64:51-58.
12. Jørgensen JO, Pedersen SA, Laurberg P, Weeke J, Skakkebaek NE, Christiansen JS (1989) Effects of growth hormone therapy on thyroid function of growth hormone-deficient adults with and without concomitant thyroxine-substituted central hypothyroidism. J Clin Endocrinol Metab69:1127-1132.
13. Kalant H (1998) Pharmacological interactions of aging and alcohol, in Alcohol Problems and Aging: NIAAA Research Monograph 33 NIH Pub No: 98-4163 (Gomberg ESL, Hegedus AM, Zucker RA eds), pp 99-116.NIH Publications, Bethesda.
14. Keenan BS, Richards GE, Ponder SW, Dallas JS, Nagamani M, Smith ER (1993) Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. J Clin Endocrinol Metab76:996-1001.
15. Link K, Blizzard RM, Evans WS, Kaiser DL, Parker MW, Rogol AD (1986) The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males. J Clin Endocrinol Metab62:159-164.
16. Mendelson JH, Mello NK, Ellingboe J (1977) Effects of acute alcohol intake on pituitary gonadal hormones in normal males. J Pharmacol Exp Ther202:676-682.
17. Mumenthaler MS, Taylor JL, O'Hara R, Fisch HU, Yesavage JA (1999) Effects of menstrual cycle and female sex steroids on ethanol pharmacokinetics. Alcohol Clin Exp Res23:250-255.
18. Orpana AK, Harkonen M, Peter-Eriksson CJ (1990) Ethanol-induced inhibition of testosterone biosynthesis in rat Leydig cells: role of mitochondrial substrate shuttles and citrates. Alcohol Alcohol25:499-507.
19. Potter JJ, Yang VW, Mezey E (1993) Regulation of the rat class I alcohol dehydrogenase gene by growth hormone. Biochem Biophys Res Comm191:1040-1045.
20. Ramchandani VA, Bolane J, Li T-K, O'Connor S (1999) A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping. Alcohol Clin Exp Res23:617-623.
21. Ramchandani VA, Bosron WF, Li T-K (2001a) Research advances in ethanol metabolism. Pathol Biol49:676-682.
22. Ramchandani VA, Kwo PY, Li T-K (2001b) Influence of food and food composition on alcohol elimination rates in healthy men and women. J Clin Pharmacol41:1345-1350.
23. Ramchandani VA, O'Connor S (2006) Studying alcohol elimination using the alcohol clamp method. Alcohol Res Health29:286-290.
24. Sarkola T, Eriksson CJ (2003) Testosterone increases in men after a low dose of alcohol. Alcohol Clin Exp Res27:682-685.
25. Sarkola T, Fukunaga T, Mäkisalo H, Peter-Eriksson CJ (2000) Acute effect of alcohol on androgens in premenopausal women. Alcohol Alcohol35:84-90.
26. Sarkola T, Mäkisalo H, Fukunaga T, Eriksson CJ (1999) Acute effect of alcohol on estradiol, estrone, progesterone, prolactin, cortisol, and luteinizing hormone in premenopausal women. Alcohol Clin Exp Res23:976-982.
27. Sato N, Lindros KO, Baraona E, Ikejima K, Mezey E, Jarvelainen H, Ramchandani VA (2001) Gender differences in alcohol-related organ injury. Alcohol Clin Exp Res25:49S-53S.
28. Sonntag WE, Boyd RL (1988) Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1. Life Sci43:1325-1330.
29. Sonntag WE, Boyd RL (1989) Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release. Alcohol Clin Exp Res13:3-7.
30. Soszynski PA, Frohman LA (1992) Inhibitory effects of ethanol on the growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-I axis in the rat. Endocrinology131:2603-2608.
31. Thomasson HR (1995) Gender differences in alcohol metabolism: physiological responses to alcohol, in Recent Developments in Alcoholism: Women and Alcoholism (Galanter M ed), pp 163-179. Plenum Press, New York.
32. Thomasson HR (2000) Alcohol elimination: faster in women?Alcohol Clin Exp Res24:419-420.
33. Thompson RG, Rodriguez A, Kowarski A, Blizzard RM (1972) Growth hormone: metabolic clearance rates, integrated concentrations, and production rates in normal adults and the effect of prednisone. J Clin Invest51:3193-3199.
34. Ulloa-Aguirre A, Blizzard RM, Garcia-Rubi E, Rogol AD, Link K, Christie CM, Johnson ML, Veldhuis JD (1990) Testosterone and oxandrolone, a non-aromatizable androgen, specifically amplify the mass and rate of growth hormone (GH) secreted per burst without altering GH secretory burst duration or frequency or the GH half-life. J Clin Endocrinol Metab71:846-854.
35. Valimaki M, Tuominen JA, Huhtaniemi I, Ylikahri R (1990) The pulsatile secretion of gonadotropins and growth hormone, and the biological activity of luteinizing hormone in men acutely intoxicated with ethanol. Alcohol Clin Exp Res14:928-931.
36. Välimäki MJ, Härkönen M, Eriksson CJ, Ylikahri RH (1984) Sex hormones and adrenocortical steroids in men acutely intoxicated with ethanol. Alcohol1:89-93.
37. Vermuelen A, Verdonck L, Kaufman JM (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab84:3666-3672.