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Volumn 81, Issue 12, 1996, Pages 4268-4271

Effect of replacement estrogen on insulin-like growth factor-I in postmenopausal women: The Rancho Bernardo study

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; PROGESTERONE; SOMATOMEDIN C;

EID: 0029819386     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.12.4268     Document Type: Article
Times cited : (52)

References (50)
  • 1
    • 0028807373 scopus 로고
    • Insulin and insulin-like growth factor 1 enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms
    • Fryburg DA, Jahn LA, Hill SA, Oliveras DM, Barrett EJ. 1995 Insulin and insulin-like growth factor 1 enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest. 96:1722-1729.
    • (1995) J Clin Invest , vol.96 , pp. 1722-1729
    • Fryburg, D.A.1    Jahn, L.A.2    Hill, S.A.3    Oliveras, D.M.4    Barrett, E.J.5
  • 2
    • 0000915437 scopus 로고
    • Antibody-suppressible, and nonsuppressible insulin-like activities in human serum and their physiologic significance: An insulin assay with adipose tissue of increased precision and specificity
    • Froesch ER, Burgi H, Ramseier EB, Bally P, Labhart A. 1963 Antibody-suppressible, and nonsuppressible insulin-like activities in human serum and their physiologic significance: an insulin assay with adipose tissue of increased precision and specificity. J Clin Invest. 42:1816-1834.
    • (1963) J Clin Invest , vol.42 , pp. 1816-1834
    • Froesch, E.R.1    Burgi, H.2    Ramseier, E.B.3    Bally, P.4    Labhart, A.5
  • 3
    • 0014031115 scopus 로고
    • Nonsuppressible insulin-like activity of human serum. II. Biological properties of plasma extracts with nonsuppressible insulin-like activity
    • Froesch ER, Muller WA, Burgi H, Waldvogel M, Labhart A. 1966 Nonsuppressible insulin-like activity of human serum. II. Biological properties of plasma extracts with nonsuppressible insulin-like activity. Biochim Biophys Acta. 121:360-374.
    • (1966) Biochim Biophys Acta , vol.121 , pp. 360-374
    • Froesch, E.R.1    Muller, W.A.2    Burgi, H.3    Waldvogel, M.4    Labhart, A.5
  • 4
    • 0014115404 scopus 로고
    • Clearance and metabolic action of insulin and nonsuppressible insulin-like activity (NSILA) in the isolated perfused rat heart
    • Solomon SS, Challoner DR, Ensinck JW, Williams RH. 1967 Clearance and metabolic action of insulin and nonsuppressible insulin-like activity (NSILA) in the isolated perfused rat heart. Diabetes. 16:545-550.
    • (1967) Diabetes , vol.16 , pp. 545-550
    • Solomon, S.S.1    Challoner, D.R.2    Ensinck, J.W.3    Williams, R.H.4
  • 6
    • 0029072757 scopus 로고
    • Growth hormone, insulin-like growth factors and bone metabolism
    • Wuster C. 1995 Growth hormone, insulin-like growth factors and bone metabolism. Endocrinology and Metabolism. 2:3-12.
    • (1995) Endocrinology and Metabolism , vol.2 , pp. 3-12
    • Wuster, C.1
  • 8
    • 0027008753 scopus 로고
    • Insulin-like growth factors, and diabetes
    • Bach LA, Rechler MM. 1992 Insulin-like growth factors, and diabetes. Diabetes Metab Rev. 8:229-257.
    • (1992) Diabetes Metab Rev , vol.8 , pp. 229-257
    • Bach, L.A.1    Rechler, M.M.2
  • 9
    • 0027180855 scopus 로고
    • Insulin-like growth factors, and cerebral ischemia
    • Lee W-H, Bondy C. 1993 Insulin-like growth factors, and cerebral ischemia. Ann NY Acad Sci. 679:418-422.
    • (1993) Ann NY Acad Sci , vol.679 , pp. 418-422
    • Lee, W.-H.1    Bondy, C.2
  • 10
    • 0026719876 scopus 로고
    • Low plasma levels of insulin-like growth factor I (IGF-I) in male patients with idiopathic osteoporosis
    • Ljunghall S, Johansson AB, Burman P, Kampe O, Lindh E, Karlsson FA. 1992 Low plasma levels of insulin-like growth factor I (IGF-I) in male patients with idiopathic osteoporosis. J Intern Med. 232:59-64.
    • (1992) J Intern Med , vol.232 , pp. 59-64
    • Ljunghall, S.1    Johansson, A.B.2    Burman, P.3    Kampe, O.4    Lindh, E.5    Karlsson, F.A.6
  • 12
    • 0026463109 scopus 로고
    • The bone mineral density in acquired growth hormone deficiency correlates with circulating levels of insulin-like growth factor I
    • Johansson AG, Burman P, Westermark K, Ljunghall S. 1992 The bone mineral density in acquired growth hormone deficiency correlates with circulating levels of insulin-like growth factor I. J Intern Med. 232:447-452.
    • (1992) J Intern Med , vol.232 , pp. 447-452
    • Johansson, A.G.1    Burman, P.2    Westermark, K.3    Ljunghall, S.4
  • 13
    • 0029115316 scopus 로고
    • Insulin-like growth factor I, and renal function
    • Hirschberg R, Kopple JD. 1995 Insulin-like growth factor I, and renal function. Diabetes Rev. 3:177-195.
    • (1995) Diabetes Rev , vol.3 , pp. 177-195
    • Hirschberg, R.1    Kopple, J.D.2
  • 14
    • 0021873617 scopus 로고
    • Insulin-like growth factor, and insulin: Comparative aspects
    • Froesch ER, Zapf J. 1985 Insulin-like growth factor, and insulin: comparative aspects. Diabetologia. 28:485-493.
    • (1985) Diabetologia , vol.28 , pp. 485-493
    • Froesch, E.R.1    Zapf, J.2
  • 15
    • 0023098492 scopus 로고
    • Effects of sex and age on the 24-hour profile of growth hormone secretion in man: Importance of endogenous estradiol concentrations
    • Ho KY, Evans WS, Blizzard RM, et al. 1987 Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. 64:51-58.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 51-58
    • Ho, K.Y.1    Evans, W.S.2    Blizzard, R.M.3
  • 17
    • 0024562230 scopus 로고
    • Effect of repetitive administration of growth hormone-releasing hormone on growth hormone secretion, insulin-like growth factor I, and bone metabolism in postmenopausal women
    • Copenh
    • Franchimont P, Urbain-Choffray D, Lambelin P, Fontaine M-A, Frangin G, Reginster J-Y. 1989 Effect of repetitive administration of growth hormone-releasing hormone on growth hormone secretion, insulin-like growth factor I, and bone metabolism in postmenopausal women. Acta Endocrinol (Copenh). 120:121-128.
    • (1989) Acta Endocrinol , vol.120 , pp. 121-128
    • Franchimont, P.1    Urbain-Choffray, D.2    Lambelin, P.3    Fontaine, M.-A.4    Frangin, G.5    Reginster, J.-Y.6
  • 18
    • 0028912544 scopus 로고
    • Insulin-like growth factors I, and II in healthy women with and without established osteoporosis
    • Raven P, Overgaard K, Spencer EM, Christiansen C. 1995 Insulin-like growth factors I, and II in healthy women with and without established osteoporosis. Eur J Endocrinol. 132:313-319.
    • (1995) Eur J Endocrinol , vol.132 , pp. 313-319
    • Raven, P.1    Overgaard, K.2    Spencer, E.M.3    Christiansen, C.4
  • 19
    • 0022494612 scopus 로고
    • Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: Effect of physiological estrogen replacement
    • Dawson-Hughes B, Stern D, Goldman J, Reichlin S. 1986 Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement. J Clin Endocrinol Metab. 63:424-432.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 424-432
    • Dawson-Hughes, B.1    Stern, D.2    Goldman, J.3    Reichlin, S.4
  • 20
    • 0021209848 scopus 로고
    • Changes in serum somatomedin and growth hormone concentrations after 3 weeks oestrogen substitution in post-menopausal women; a pilot study
    • Copenh
    • Duursma SA, Bijlsma WJ, Paassen HC, van Buul-Offers SC, Skottner-Lundin A. 1984 Changes in serum somatomedin and growth hormone concentrations after 3 weeks oestrogen substitution in post-menopausal women; a pilot study. Acta Endocrinol (Copenh). 6:527-531.
    • (1984) Acta Endocrinol , vol.6 , pp. 527-531
    • Duursma, S.A.1    Bijlsma, W.J.2    Paassen, H.C.3    Van Buul-Offers, S.C.4    Skottner-Lundin, A.5
  • 21
    • 0025882208 scopus 로고
    • Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women
    • Weissberger AJ, Ho KKY, Lazarus L. 1991 Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women. J Clin Endocrinol Metab. 72:374-381.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 374-381
    • Weissberger, A.J.1    Ho, K.K.Y.2    Lazarus, L.3
  • 22
    • 0027730324 scopus 로고
    • Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels
    • Campagnoli C, Biglia N, Altare F, et al. 1993 Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels. Gynecol Endocrinol. 7:251-258.
    • (1993) Gynecol Endocrinol , vol.7 , pp. 251-258
    • Campagnoli, C.1    Biglia, N.2    Altare, F.3
  • 23
    • 0027935871 scopus 로고
    • Serum insulin-like growth factor I in a random population sample of men and women: Relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin
    • Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, et al. 1994 Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clinical Endocrinology. 41:351-357.
    • (1994) Clinical Endocrinology , vol.41 , pp. 351-357
    • Landin-Wilhelmsen, K.1    Wilhelmsen, L.2    Lappas, G.3
  • 24
    • 0025037898 scopus 로고
    • Community-based study of prevalence of NIDDM in older adults
    • Wingard DL, Sinsheimer P, Barrett-Connor E, et al. 1990 Community-based study of prevalence of NIDDM in older adults. Diabetes Care. 13:3-8.
    • (1990) Diabetes Care , vol.13 , pp. 3-8
    • Wingard, D.L.1    Sinsheimer, P.2    Barrett-Connor, E.3
  • 25
    • 0018959529 scopus 로고
    • Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: A comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol extracted serum
    • Daughaday WH, Mariz IK, Blethen SI. 1980 Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol extracted serum. J Clin Endocrinol Metab. 51:781-788.
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 781-788
    • Daughaday, W.H.1    Mariz, I.K.2    Blethen, S.I.3
  • 26
    • 0027466531 scopus 로고
    • The insulin-like growth factors
    • Cohick S, Clemmons DR. 1993 The insulin-like growth factors. Annu Rev Physiol. 55:131-153.
    • (1993) Annu Rev Physiol , vol.55 , pp. 131-153
    • Cohick, S.1    Clemmons, D.R.2
  • 27
    • 0026757027 scopus 로고
    • 17β-estradiol combined with oral progestogen increases plasma levels of insulin-like growth factor-I in postmenopausal women
    • Slowinska-Srzednicka J, Zgliczynski S, Jeske W, et al. 1992 17β-estradiol combined with oral progestogen increases plasma levels of insulin-like growth factor-I in postmenopausal women. J Endocrinol Invest. 15:533-538.
    • (1992) J Endocrinol Invest , vol.15 , pp. 533-538
    • Slowinska-Srzednicka, J.1    Zgliczynski, S.2    Jeske, W.3
  • 28
    • 0026066023 scopus 로고
    • Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-I in postmenopausal women of different ages
    • Bellantoni MF, Harman SM, Cho DE, Blackman MR. 1991 Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-I in postmenopausal women of different ages. J Clin Endocrinol Metab. 72:172-178.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 172-178
    • Bellantoni, M.F.1    Harman, S.M.2    Cho, D.E.3    Blackman, M.R.4
  • 29
    • 0028222636 scopus 로고
    • Androgenic progestogens oppose the decrease of insulin-like growth factor I serum level induced by conjugated oestrogens in postmenopausal women. Preliminary report
    • Campagnoli C, Biglia N, Lanza MG, Lesca L, Peris C, Sismondi P. 1994 Androgenic progestogens oppose the decrease of insulin-like growth factor I serum level induced by conjugated oestrogens in postmenopausal women. Preliminary report. Maturitas. 19:25-31.
    • (1994) Maturitas , vol.19 , pp. 25-31
    • Campagnoli, C.1    Biglia, N.2    Lanza, M.G.3    Lesca, L.4    Peris, C.5    Sismondi, P.6
  • 31
    • 0022652889 scopus 로고
    • Biological effects of estradiol-17b in postmenopausal women: Oral versus percutaneous administration
    • de Lignieres B, Basdevant A, Thomas G, et al. 1986 Biological effects of estradiol-17b in postmenopausal women: oral versus percutaneous administration. J Clin Endocrinol Metab. 62:536-541.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 536-541
    • De Lignieres, B.1    Basdevant, A.2    Thomas, G.3
  • 32
    • 0024593620 scopus 로고
    • Comparison of the effects of oral and transdermal oestradiol administration on oestrogen metabolism, protein synthesis, gonadotropin release, bone turnover and climacteric symptoms in postmenopausal women
    • Oxf
    • Selby PI, McGarrigle HHG, Peacock M. 1989 Comparison of the effects of oral and transdermal oestradiol administration on oestrogen metabolism, protein synthesis, gonadotropin release, bone turnover and climacteric symptoms in postmenopausal women. Clin Endocrinol (Oxf). 30:241-249.
    • (1989) Clin Endocrinol , vol.30 , pp. 241-249
    • Selby, P.I.1    McGarrigle, H.H.G.2    Peacock, M.3
  • 33
    • 0023872776 scopus 로고
    • Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat
    • Murphy LJ, Friesen HG. 1988 Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat. Endocrinology. 122:325-332.
    • (1988) Endocrinology , vol.122 , pp. 325-332
    • Murphy, L.J.1    Friesen, H.G.2
  • 34
    • 0027449177 scopus 로고
    • Associations of post-menopausal estrogen use with cardiovascular disease and its risk factors in older women
    • Manolio TA, Furberg CD, Shemanski L, et al. 1993 Associations of post-menopausal estrogen use with cardiovascular disease and its risk factors in older women. Circulation. 88:2163-2171.
    • (1993) Circulation , vol.88 , pp. 2163-2171
    • Manolio, T.A.1    Furberg, C.D.2    Shemanski, L.3
  • 35
    • 0027401344 scopus 로고
    • Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women
    • The Atherosclerosis Risk In Communities Study Investigators
    • Nabulsi AA, Folsom AR, White A, et al. 1993 Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. The Atherosclerosis Risk In Communities Study Investigators. N Engl J Med. 328:1069-1075.
    • (1993) N Engl J Med , vol.328 , pp. 1069-1075
    • Nabulsi, A.A.1    Folsom, A.R.2    White, A.3
  • 36
  • 37
    • 0018345196 scopus 로고
    • Estrogen replacement therapy I: A 10 year prospective study in the relationship to osteoporosis
    • Nachtigal LE, Nachtigall RH, Bachtigall RD, Beckman EM. 1979 Estrogen replacement therapy I: a 10 year prospective study in the relationship to osteoporosis. Obstet Gynecol. 53:277-281.
    • (1979) Obstet Gynecol , vol.53 , pp. 277-281
    • Nachtigal, L.E.1    Nachtigall, R.H.2    Bachtigall, R.D.3    Beckman, E.M.4
  • 38
    • 0027370551 scopus 로고
    • Body fat in Laron syndrome patients: Effect of insulin-like growth factor I treatment
    • Laron Z, Klinger B. 1993 Body fat in Laron syndrome patients: effect of insulin-like growth factor I treatment. Horm Res. 40:16-22.
    • (1993) Horm Res , vol.40 , pp. 16-22
    • Laron, Z.1    Klinger, B.2
  • 39
    • 77957126077 scopus 로고
    • Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women
    • The Writing Group for the PEPI Trial. 1995 Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. JAMA. 273:199-208.
    • (1995) JAMA , vol.273 , pp. 199-208
  • 40
    • 0024550043 scopus 로고
    • Postmenopausal estrogen use and heart disease risk factors in the 1980s
    • Barrett-Connor E, Wingard DL, Criqui MH. 1989 Postmenopausal estrogen use and heart disease risk factors in the 1980s. JAMA. 261:2095-2100.
    • (1989) JAMA , vol.261 , pp. 2095-2100
    • Barrett-Connor, E.1    Wingard, D.L.2    Criqui, M.H.3
  • 41
    • 0027434964 scopus 로고
    • Effects of different oral oestrogen formulations on insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women
    • Oxf
    • Kelly JJ, Rajkovic IA, O'Sullivan AJ, Sernia C, Ho KK. 1993 Effects of different oral oestrogen formulations on insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women. Clin Endocrinol (Oxf). 39:561-567.
    • (1993) Clin Endocrinol , vol.39 , pp. 561-567
    • Kelly, J.J.1    Rajkovic, I.A.2    O'Sullivan, A.J.3    Sernia, C.4    Ho, K.K.5
  • 42
    • 0023872776 scopus 로고
    • Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat
    • Murphy LJ, Friesen HG. 1988 Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat. Endocrinology. 122:325-332.
    • (1988) Endocrinology , vol.122 , pp. 325-332
    • Murphy, L.J.1    Friesen, H.G.2
  • 43
    • 0024854194 scopus 로고
    • The effects of treatment with recombinant human growth hormone on body composition and metabolism and adults with growth hormone deficiency
    • Salomon F, Cuneo RC, Hesp R, Sonksen PH. 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism and adults with growth hormone deficiency. N Engl J Med. 312:1797-1803.
    • (1989) N Engl J Med , vol.312 , pp. 1797-1803
    • Salomon, F.1    Cuneo, R.C.2    Hesp, R.3    Sonksen, P.H.4
  • 44
    • 0025159241 scopus 로고
    • Effects of short-term administration of rhGH to elderly people
    • Marcus R, Butterfield G, Holloway L, et al. 1990 Effects of short-term administration of rhGH to elderly people. J Clin Endocrinol Metab. 7:519-527.
    • (1990) J Clin Endocrinol Metab , vol.7 , pp. 519-527
    • Marcus, R.1    Butterfield, G.2    Holloway, L.3
  • 45
    • 0025786144 scopus 로고
    • The effect of growth hormone (GH) therapy on urinary pyridinoline cross links in GH-deficient adults
    • Oxf
    • Schlemmer A, Johansen JS, Pedersen SA, Jorgensen J, Hassager C. 1991 The effect of growth hormone (GH) therapy on urinary pyridinoline cross links in GH-deficient adults. Clin Endocrinol (Oxf). 35:471-476.
    • (1991) Clin Endocrinol , vol.35 , pp. 471-476
    • Schlemmer, A.1    Johansen, J.S.2    Pedersen, S.A.3    Jorgensen, J.4    Hassager, C.5
  • 46
    • 0025349073 scopus 로고
    • A short course of rhGH treatment stimulates osteoblasts and activates bone remodeling in normal human volunteers
    • Brixen K, Nielsen HK, Moskilde L, Flyvbjerg A. 1990 A short course of rhGH treatment stimulates osteoblasts and activates bone remodeling in normal human volunteers. J Bone Miner Res. 5:609-618.
    • (1990) J Bone Miner Res , vol.5 , pp. 609-618
    • Brixen, K.1    Nielsen, H.K.2    Moskilde, L.3    Flyvbjerg, A.4
  • 47
    • 0027142906 scopus 로고
    • Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency
    • Cuneo RC, Salomon F, Watts GF, Hesp R, Sonksen PH. 1993 Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism. 42:1519-1523.
    • (1993) Metabolism , vol.42 , pp. 1519-1523
    • Cuneo, R.C.1    Salomon, F.2    Watts, G.F.3    Hesp, R.4    Sonksen, P.H.5
  • 48
    • 0027439812 scopus 로고
    • Growth hormone treatment of growth hormone deficient adults results in marked increase in Lp(a) and HDL cholesterol concentrations
    • Eden S, Wiklund O, Oscarsson J, Rosen T, Bengtsson B-A. 1993 Growth hormone treatment of growth hormone deficient adults results in marked increase in Lp(a) and HDL cholesterol concentrations. Arterioscler Thromb. 13:296-301.
    • (1993) Arterioscler Thromb , vol.13 , pp. 296-301
    • Eden, S.1    Wiklund, O.2    Oscarsson, J.3    Rosen, T.4    Bengtsson, B.-A.5
  • 50
    • 0002007361 scopus 로고
    • Neuroendocrine regulation and diseases of the anterior pituitary and hypothalamus
    • Wilson JD, Brauwald E, Isselbacker, KJ, et al. (eds) New York: McGraw-Hill
    • Daniels GH, Martin JB. 1991 Neuroendocrine regulation and diseases of the anterior pituitary and hypothalamus. In: Wilson JD, Brauwald E, Isselbacker, KJ, et al. (eds) Harrison's Principles of Internal Medicine, ed 12. New York: McGraw-Hill; vol 2:1655-1679.
    • (1991) Harrison's Principles of Internal Medicine, Ed 12 , vol.2 , pp. 1655-1679
    • Daniels, G.H.1    Martin, J.B.2


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