Effect of ciprofloxacin/dexamethasone versus ciprofloxacin/hydrocortisone on lipopolysaccharide-induced experimental otitis media

Otolaryngology - Head and Neck Surgery

Volumn 145, Issue 2, 2011, Pages 288-294

  Dattaray, Piali ^a,b   Pudrith, Charles ^a,b   Nyc, Mary Ann ^a,b   Martin, Dusan ^a,b   Kim, You Hyun ^a,b   Jahng, Patrick ^a,b   Chung, You Sun ^a,b   Wall, G Michael ^c   Jung, Timothy ^a,b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Jerry L Pettis Memorial VA Medical Center   (United States)

^c ALCON RESEARCH LTD   (United States)

Author keywords

Chinchilla; Ciprodex; CiproHC; LPS; Middle ear effusion; Mucosal thickness; Otitis media

Indexed keywords

CIPROFLOXACIN PLUS DEXAMETHASONE; CIPROFLOXACIN PLUS HYDROCORTISONE; LIPOPOLYSACCHARIDE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CIPROFLOXACIN; DEXAMETHASONE; HYDROCORTISONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINCHILLA; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; MALE; MIDDLE EAR EFFUSION; NONHUMAN; OTITIS MEDIA; OUTCOME ASSESSMENT; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECT; MUCOSA; PATHOLOGY; PERIOSTEUM; SECRETORY OTITIS MEDIA; TEMPORAL BONE; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; CHINCHILLA; CIPROFLOXACIN; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; HYDROCORTISONE; LIPOPOLYSACCHARIDES; MALE; MUCOUS MEMBRANE; OTITIS MEDIA WITH EFFUSION; PERIOSTEUM; TEMPORAL BONE; TREATMENT OUTCOME;

EID: 84856378377     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599811403868     Document Type: Article

References (13)

1. Kenna MA, Rosane BA, Bluestone CD. Medical management of chronic suppurative otitis media without cholesteatoma in children - update. Am J Otol. 1993;14:469.
2. Rosenfeld RM, Culpepper L, Doyle KJ, et al. Clinical practice guideline: otitis media with effusion. Otolaryngol Head Neck Surg. 2004;103:s95-s118.
3. Fliss DM, Dagan R, Houri Z, et al. Medical management of chronic suppurative otitis media without cholesteatoma in children. J Pediatr. 1990;116:991-996. (Pubitemid 20201716)
4. Berman S. Otitis media in children. N Engl J Med. 1995;332:1560-1565.
5. Jung TT. Prostaglandins, leukotrienes, and other arachidonic acid metabolites in the pathogenesis of otitis media. Laryngoscope. 1998;98:980-993.
6. Jung TT, Choi K, Park YS, et al. Effect of prostaglandin, leukotriene, and arachidonic acid on experimental otitis media with effusion in chinchillas. Ann Otol Rhinolaryngol. 1990;99:28-32. (Pubitemid 20202220)
7. Baggett HC, Prazma J, Rose AS, et al. The role of glucocorticoids in endotoxin-mediated otitis media with effusion. Arch Otolaryngol Head Neck Surg. 1997;123:41-46. (Pubitemid 27043656)
8. Herman P, Tan CT, Van Den Abbelle T, et al. Glucocorticosteroids increase sodium transport in middle ear epithelium. Am J Physiol. 1997;272:184-190.
9. Florea A, Zwart JE, Lee C, et al. Effect of topical dexamethasone versus rimexolone on middle ear inflammation in experimental otitis media with effusion. Acta Otolaryngol. 2006;126:910-915.
10. Juhn SK, Jung TT. Inflammatory changes reflected in middle ear effusion in otitis media. Auris Nasus Larynx. 1985;(12 suppl 1):S63-S66.
11. DeMaria TF. Localization of nontypeable Haemophilus influenzae endotoxin in the middle and inner ear during experimental otitis media. Acta Otolaryngol. 1999;119(5):583-587. (Pubitemid 29378951)
12. Diederich S, Eigendorff E, Burkhardt P, et al. 11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids. J Clin Endocrinol Metab. 2002;87:5695-5701. (Pubitemid 36034378)
13. Roland PS, Kreisler LS, Reese B, et al. Topical ciprofloxacin/ dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes. Pediatrics. 2004;113(1):e40-e246.