메뉴 건너뛰기




Volumn 21, Issue 1, 2012, Pages 8-19

Bone health management in patients with breast cancer: Current standards and emerging strategies

Author keywords

Anticancer; Bisphosphonate; Bone metastases; Bone mineral density; Skeletal related event; Zoledronic acid

Indexed keywords

ALENDRONIC ACID; AMINO TERMINAL TELOPEPTIDE; ANASTROZOLE; AROMATASE INHIBITOR; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CLODRONIC ACID; DENOSUMAB; DOCETAXEL; DOXORUBICIN; ESTROGEN; GOSERELIN; IBANDRONIC ACID; LETROZOLE; OSTEOCLAST DIFFERENTIATION FACTOR; PACLITAXEL; PAMIDRONIC ACID; PLACEBO; RISEDRONIC ACID; TAMOXIFEN; VITAMIN D; ZOLEDRONIC ACID;

EID: 84856345986     PISSN: 09609776     EISSN: 15323080     Source Type: Journal    
DOI: 10.1016/j.breast.2011.08.138     Document Type: Review
Times cited : (15)

References (123)
  • 1
    • 63149172286 scopus 로고    scopus 로고
    • The decline in breast cancer incidence: real or imaginary?
    • Kurian A.W., Clarke C.A., Carlson R.W. The decline in breast cancer incidence: real or imaginary?. Curr Oncol Rep 2009, 11:21-28.
    • (2009) Curr Oncol Rep , vol.11 , pp. 21-28
    • Kurian, A.W.1    Clarke, C.A.2    Carlson, R.W.3
  • 2
    • 77949561690 scopus 로고    scopus 로고
    • American Cancer Society, American Cancer Society, Inc., Atlanta
    • Breast cancer facts and figures 2009-2010 2009, American Cancer Society, American Cancer Society, Inc., Atlanta.
    • (2009) Breast cancer facts and figures 2009-2010
  • 4
    • 0036903764 scopus 로고    scopus 로고
    • Efficacy of bisphosphonates in the management of skeletal complications of bone metastases and selection of clinical endpoints
    • Major P.P., Cook R. Efficacy of bisphosphonates in the management of skeletal complications of bone metastases and selection of clinical endpoints. Am J Clin Oncol 2002, 25:S10-S18.
    • (2002) Am J Clin Oncol , vol.25
    • Major, P.P.1    Cook, R.2
  • 5
    • 67649804881 scopus 로고    scopus 로고
    • Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: Z-FAST study 36-month follow-up results
    • Brufsky A.M., Bosserman L.D., Caradonna R.R., Haley B.B., Jones C.M., Moore H.C., et al. Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: Z-FAST study 36-month follow-up results. Clin Breast Cancer 2009, 9:77-85.
    • (2009) Clin Breast Cancer , vol.9 , pp. 77-85
    • Brufsky, A.M.1    Bosserman, L.D.2    Caradonna, R.R.3    Haley, B.B.4    Jones, C.M.5    Moore, H.C.6
  • 6
    • 77954580167 scopus 로고    scopus 로고
    • Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST study
    • Eidtmann H., de Boer R., Bundred N., Llombart-Cussac A., Davidson N., Neven P., et al. Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST study. Ann Oncol 2010, 21:2188-2194.
    • (2010) Ann Oncol , vol.21 , pp. 2188-2194
    • Eidtmann, H.1    de Boer, R.2    Bundred, N.3    Llombart-Cussac, A.4    Davidson, N.5    Neven, P.6
  • 7
    • 49949115926 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy
    • Gnant M., Mlineritsch B., Luschin-Ebengreuth G., Kainberger F., Kassmann H., Piswanger-Solkner J.C., et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy. Lancet Oncol 2008, 9:840-849.
    • (2008) Lancet Oncol , vol.9 , pp. 840-849
    • Gnant, M.1    Mlineritsch, B.2    Luschin-Ebengreuth, G.3    Kainberger, F.4    Kassmann, H.5    Piswanger-Solkner, J.C.6
  • 8
    • 84856329246 scopus 로고    scopus 로고
    • Zoledronic acid prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole
    • E-ZO-FAST 36-month follow-up. Presented at: American Society of Clinical Oncology 2009 Breast Cancer Symposium; October 8-10, San Francisco, CA [Abstract
    • Llombart A, Frassoldati A, Paija O, Sleeboom HP, Jerusalem G, Mebis J, etal. Zoledronic acid prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: E-ZO-FAST 36-month follow-up. Presented at: American Society of Clinical Oncology 2009 Breast Cancer Symposium; October 8-10, 2009; San Francisco, CA [Abstract 213].
    • (2009)
    • Llombart, A.1    Frassoldati, A.2    Paija, O.3    Sleeboom, H.P.4    Jerusalem, G.5    Mebis, J.6
  • 9
    • 46849110780 scopus 로고    scopus 로고
    • Practical guidance for the management of aromatase inhibitor-associated bone loss
    • Hadji P., Body J.-J., Aapro M.S., Brufsky A., Coleman R.E., Guise T., et al. Practical guidance for the management of aromatase inhibitor-associated bone loss. Ann Oncol 2008, 19:1407-1416.
    • (2008) Ann Oncol , vol.19 , pp. 1407-1416
    • Hadji, P.1    Body, J.-J.2    Aapro, M.S.3    Brufsky, A.4    Coleman, R.E.5    Guise, T.6
  • 10
    • 34347372696 scopus 로고    scopus 로고
    • The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
    • Kanis J.A., Oden A., Johnell O., Johansson H., De Laet C., Brown J., et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 2007, 18:1033-1046.
    • (2007) Osteoporos Int , vol.18 , pp. 1033-1046
    • Kanis, J.A.1    Oden, A.2    Johnell, O.3    Johansson, H.4    De Laet, C.5    Brown, J.6
  • 11
    • 0028963682 scopus 로고
    • Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group
    • Cummings S.R., Nevitt M.C., Browner W.S., Stone K., Fox K.M., Ensrud K.E., et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. NEngl J Med 1995, 332:767-773.
    • (1995) NEngl J Med , vol.332 , pp. 767-773
    • Cummings, S.R.1    Nevitt, M.C.2    Browner, W.S.3    Stone, K.4    Fox, K.M.5    Ensrud, K.E.6
  • 12
    • 0035879298 scopus 로고    scopus 로고
    • Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer
    • Shapiro C.L., Manola J., Leboff M. Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer. JClin Oncol 2001, 19:3306-3311.
    • (2001) JClin Oncol , vol.19 , pp. 3306-3311
    • Shapiro, C.L.1    Manola, J.2    Leboff, M.3
  • 13
    • 5444276106 scopus 로고    scopus 로고
    • Bone mineral density in premenopausal women treated for node-positive early breast cancer with 2 years of goserelin or 6 months of cyclophosphamide, methotrexate and 5-fluorouracil (CMF)
    • Fogelman I., Blake G.M., Blamey R., Palmer M., Sauerbrei W., Schumacher M., et al. Bone mineral density in premenopausal women treated for node-positive early breast cancer with 2 years of goserelin or 6 months of cyclophosphamide, methotrexate and 5-fluorouracil (CMF). Osteoporos Int 2003, 14:1001-1006.
    • (2003) Osteoporos Int , vol.14 , pp. 1001-1006
    • Fogelman, I.1    Blake, G.M.2    Blamey, R.3    Palmer, M.4    Sauerbrei, W.5    Schumacher, M.6
  • 14
    • 33947539707 scopus 로고    scopus 로고
    • Zoledronic acid prevents cancer treatment-induced bone loss in premenopausal women receiving adjuvant endocrine therapy for hormone-responsive breast cancer: a report from the Austrian Breast and Colorectal Cancer Study Group
    • Gnant M.F., Mlineritsch B., Luschin-Ebengreuth G., Grampp S., Kaessmann H., Schmid M., et al. Zoledronic acid prevents cancer treatment-induced bone loss in premenopausal women receiving adjuvant endocrine therapy for hormone-responsive breast cancer: a report from the Austrian Breast and Colorectal Cancer Study Group. JClin Oncol 2007, 25:820-828.
    • (2007) JClin Oncol , vol.25 , pp. 820-828
    • Gnant, M.F.1    Mlineritsch, B.2    Luschin-Ebengreuth, G.3    Grampp, S.4    Kaessmann, H.5    Schmid, M.6
  • 15
    • 33846545488 scopus 로고    scopus 로고
    • Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study
    • Coleman R.E., Banks L.M., Girgis S.I., Kilburn L.S., Vrdoljak E., Fox J., et al. Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study. Lancet Oncol 2007, 8:119-127.
    • (2007) Lancet Oncol , vol.8 , pp. 119-127
    • Coleman, R.E.1    Banks, L.M.2    Girgis, S.I.3    Kilburn, L.S.4    Vrdoljak, E.5    Fox, J.6
  • 16
    • 41949094767 scopus 로고    scopus 로고
    • Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230
    • Eastell R., Adams J.E., Coleman R.E., Howell A., Hannon R.A., Cuzick J., et al. Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230. JClin Oncol 2008, 26:1051-1057.
    • (2008) JClin Oncol , vol.26 , pp. 1051-1057
    • Eastell, R.1    Adams, J.E.2    Coleman, R.E.3    Howell, A.4    Hannon, R.A.5    Cuzick, J.6
  • 17
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • Howell A., Cuzick J., Baum M., Buzdar A., Dowsett M., Forbes J.F., et al. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 2005, 365:60-62.
    • (2005) Lancet , vol.365 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3    Buzdar, A.4    Dowsett, M.5    Forbes, J.F.6
  • 18
    • 33747058527 scopus 로고    scopus 로고
    • Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17
    • Perez E.A., Josse R.G., Pritchard K.I., Ingle J.N., Martino S., Findlay B.P., et al. Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17. JClin Oncol 2006, 24:3629-3635.
    • (2006) JClin Oncol , vol.24 , pp. 3629-3635
    • Perez, E.A.1    Josse, R.G.2    Pritchard, K.I.3    Ingle, J.N.4    Martino, S.5    Findlay, B.P.6
  • 19
    • 29544433211 scopus 로고    scopus 로고
    • Acomparison of letrozole and tamoxifen in postmenopausal women with early breast cancer
    • Thurlimann B., Keshaviah A., Coates A.S., Mouridsen H., Mauriac L., Forbes J.F., et al. Acomparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. NEngl J Med 2005, 353:2747-2757.
    • (2005) NEngl J Med , vol.353 , pp. 2747-2757
    • Thurlimann, B.1    Keshaviah, A.2    Coates, A.S.3    Mouridsen, H.4    Mauriac, L.5    Forbes, J.F.6
  • 20
    • 33947524592 scopus 로고    scopus 로고
    • Zoledronic acid inhibits adjuvant letrozole-induced bone loss in postmenopausal women with early breast cancer
    • Brufsky A., Harker W.G., Beck J.T., Carroll R., Tan-Chiu E., Seidler C., et al. Zoledronic acid inhibits adjuvant letrozole-induced bone loss in postmenopausal women with early breast cancer. JClin Oncol 2007, 25:829-836.
    • (2007) JClin Oncol , vol.25 , pp. 829-836
    • Brufsky, A.1    Harker, W.G.2    Beck, J.T.3    Carroll, R.4    Tan-Chiu, E.5    Seidler, C.6
  • 21
    • 58149166777 scopus 로고    scopus 로고
    • Prevention of anastrozole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer
    • Lester J.E., Dodwell D., Purohit O.P., Gutcher S.A., Ellis S.P., Thorpe R., et al. Prevention of anastrozole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer. Clin Cancer Res 2008, 14:6336-6342.
    • (2008) Clin Cancer Res , vol.14 , pp. 6336-6342
    • Lester, J.E.1    Dodwell, D.2    Purohit, O.P.3    Gutcher, S.A.4    Ellis, S.P.5    Thorpe, R.6
  • 22
    • 0031045147 scopus 로고    scopus 로고
    • Clodronate improves bone mineral density in post-menopausal breast cancer patients treated with adjuvant antioestrogens
    • Saarto T., Blomqvist C., Valimaki M., Makela P., Sarna S., Elomaa I. Clodronate improves bone mineral density in post-menopausal breast cancer patients treated with adjuvant antioestrogens. Br J Cancer 1997, 75:602-605.
    • (1997) Br J Cancer , vol.75 , pp. 602-605
    • Saarto, T.1    Blomqvist, C.2    Valimaki, M.3    Makela, P.4    Sarna, S.5    Elomaa, I.6
  • 23
    • 52049093463 scopus 로고    scopus 로고
    • Ten-year follow-up of 3 years of oral adjuvant clodronate therapy shows significant prevention of osteoporosis in early-stage breast cancer
    • Saarto T., Vehmanen L., Blomqvist C., Elomaa I. Ten-year follow-up of 3 years of oral adjuvant clodronate therapy shows significant prevention of osteoporosis in early-stage breast cancer. JClin Oncol 2008, 26:4289-4295.
    • (2008) JClin Oncol , vol.26 , pp. 4289-4295
    • Saarto, T.1    Vehmanen, L.2    Blomqvist, C.3    Elomaa, I.4
  • 25
    • 34547569748 scopus 로고    scopus 로고
    • Estrogen-dependent increase in bone turnover and bone loss in postmenopausal women with breast cancer treated with anastrozole. Prevention with bisphosphonates
    • Confavreux C.B., Fontana A., Guastalla J.P., Munoz F., Brun J., Delmas P.D. Estrogen-dependent increase in bone turnover and bone loss in postmenopausal women with breast cancer treated with anastrozole. Prevention with bisphosphonates. Bone 2007, 41:346-352.
    • (2007) Bone , vol.41 , pp. 346-352
    • Confavreux, C.B.1    Fontana, A.2    Guastalla, J.P.3    Munoz, F.4    Brun, J.5    Delmas, P.D.6
  • 26
    • 45749127094 scopus 로고    scopus 로고
    • Risedronate prevents bone loss in breast cancer survivors: a 2-year, randomized, double-blind, placebo-controlled clinical trial
    • Greenspan S.L., Brufsky A., Lembersky B.C., Bhattacharya R., Vujevich K.T., Perera S., et al. Risedronate prevents bone loss in breast cancer survivors: a 2-year, randomized, double-blind, placebo-controlled clinical trial. JClin Oncol 2008, 26:2644-2652.
    • (2008) JClin Oncol , vol.26 , pp. 2644-2652
    • Greenspan, S.L.1    Brufsky, A.2    Lembersky, B.C.3    Bhattacharya, R.4    Vujevich, K.T.5    Perera, S.6
  • 27
    • 37449028391 scopus 로고    scopus 로고
    • Effect of anastrozole on bone mineral density after one year of treatment: results from bone sub-study of the International Breast Cancer Intervention Study (IBIS-II)
    • [Abstract 28]
    • Singh S., Cuzick J., Edwards R., Blake G., Truscott J., Coleman R., et al. Effect of anastrozole on bone mineral density after one year of treatment: results from bone sub-study of the International Breast Cancer Intervention Study (IBIS-II). Breast Cancer Res Treat 2007, 106(suppl. 1):S9. [Abstract 28].
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL. 1
    • Singh, S.1    Cuzick, J.2    Edwards, R.3    Blake, G.4    Truscott, J.5    Coleman, R.6
  • 28
    • 58449126956 scopus 로고    scopus 로고
    • Preventing nonvertebral osteoporotic fractures with extended-interval bisphosphonates: regimen selection and clinical application
    • Cole R.E., Harris S.T. Preventing nonvertebral osteoporotic fractures with extended-interval bisphosphonates: regimen selection and clinical application. Medscape J Med 2009, 11:12.
    • (2009) Medscape J Med , vol.11 , pp. 12
    • Cole, R.E.1    Harris, S.T.2
  • 29
    • 33746164723 scopus 로고    scopus 로고
    • Treatment persistence with once-monthly ibandronate and patient support vs. once-weekly alendronate: results from the PERSIST study
    • Cooper A., Drake J., Brankin E. Treatment persistence with once-monthly ibandronate and patient support vs. once-weekly alendronate: results from the PERSIST study. Int J Clin Pract 2006, 60:896-905.
    • (2006) Int J Clin Pract , vol.60 , pp. 896-905
    • Cooper, A.1    Drake, J.2    Brankin, E.3
  • 30
    • 33745683770 scopus 로고    scopus 로고
    • Adherence and persistence associated with the pharmacologic treatment of osteoporosis in a managed care setting
    • Downey T.W., Foltz S.H., Boccuzzi S.J., Omar M.A., Kahler K.H. Adherence and persistence associated with the pharmacologic treatment of osteoporosis in a managed care setting. South Med J 2006, 99:570-575.
    • (2006) South Med J , vol.99 , pp. 570-575
    • Downey, T.W.1    Foltz, S.H.2    Boccuzzi, S.J.3    Omar, M.A.4    Kahler, K.H.5
  • 31
    • 33947429732 scopus 로고    scopus 로고
    • Medication persistence with weekly versus daily doses of orally administered bisphosphonates
    • Ettinger M.P., Gallagher R., MacCosbe P.E. Medication persistence with weekly versus daily doses of orally administered bisphosphonates. Endocr Pract 2006, 12:522-528.
    • (2006) Endocr Pract , vol.12 , pp. 522-528
    • Ettinger, M.P.1    Gallagher, R.2    MacCosbe, P.E.3
  • 32
    • 31744447638 scopus 로고    scopus 로고
    • Adherence and persistence: impact on outcomes and health care resources
    • Reginster J.Y. Adherence and persistence: impact on outcomes and health care resources. Bone 2006, 38(suppl. 2):S18-S21.
    • (2006) Bone , vol.38 , Issue.SUPPL. 2
    • Reginster, J.Y.1
  • 33
    • 44949171731 scopus 로고    scopus 로고
    • Compliance and persistence with osteoporosis therapies
    • Silverman S.L., Gold D.T. Compliance and persistence with osteoporosis therapies. Curr Rheumatol Rep 2008, 10:118-122.
    • (2008) Curr Rheumatol Rep , vol.10 , pp. 118-122
    • Silverman, S.L.1    Gold, D.T.2
  • 34
    • 36049001492 scopus 로고    scopus 로고
    • Persistence across weekly and monthly bisphosphonates: analysis of US retail pharmacy prescription refills
    • Weiss T.W., Henderson S.C., McHorney C.A., Cramer J.A. Persistence across weekly and monthly bisphosphonates: analysis of US retail pharmacy prescription refills. Curr Med Res Opin 2007, 23:2193-2203.
    • (2007) Curr Med Res Opin , vol.23 , pp. 2193-2203
    • Weiss, T.W.1    Henderson, S.C.2    McHorney, C.A.3    Cramer, J.A.4
  • 35
    • 36549012194 scopus 로고    scopus 로고
    • Higher persistency with i.v. bisphosphonates in patients with bone metastasis
    • [Abstract 18623]
    • Mangiapane S., Hoer A., Gothe H., Barghout V., Haeussler B. Higher persistency with i.v. bisphosphonates in patients with bone metastasis. JClin Oncol 2006, 24(suppl.):698s. [Abstract 18623].
    • (2006) JClin Oncol , vol.24 , Issue.SUPPL.
    • Mangiapane, S.1    Hoer, A.2    Gothe, H.3    Barghout, V.4    Haeussler, B.5
  • 36
    • 84856349606 scopus 로고    scopus 로고
    • The effect of zoledronic acid on aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole
    • The Z-FAST study 5-year final follow-up. Presented at: 32nd Annual San Antonio Breast Cancer Symposium; December 9-13, San Antonio, TX [Abstract 4083].
    • Brufsky A, Harker G, Beck JT, Carroll R, Jin L, Warsi G, etal. The effect of zoledronic acid on aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: the Z-FAST study 5-year final follow-up. Presented at: 32nd Annual San Antonio Breast Cancer Symposium; December 9-13, 2009; San Antonio, TX [Abstract 4083].
    • (2009)
    • Brufsky, A.1    Harker, G.2    Beck, J.T.3    Carroll, R.4    Jin, L.5    Warsi, G.6
  • 38
    • 21244494910 scopus 로고    scopus 로고
    • Pamidronate in the prevention of chemotherapy-induced bone loss in premenopausal women with breast cancer: a randomized controlled trial
    • Fuleihan G.E.-H., Salamoun M., Mourad Y.A., Chehal A., Salem Z., Mahfoud Z., et al. Pamidronate in the prevention of chemotherapy-induced bone loss in premenopausal women with breast cancer: a randomized controlled trial. JClin Endocrinol Metab 2005, 90:3209-3214.
    • (2005) JClin Endocrinol Metab , vol.90 , pp. 3209-3214
    • Fuleihan, G.E.-H.1    Salamoun, M.2    Mourad, Y.A.3    Chehal, A.4    Salem, Z.5    Mahfoud, Z.6
  • 39
    • 54249151531 scopus 로고    scopus 로고
    • Zoledronic acid prevents bone loss in premenopausal women undergoing adjuvant chemotherapy for early-stage breast cancer
    • Hershman D.L., McMahon D.J., Crew K.D., Cremers S., Irani D., Cucchiara G., et al. Zoledronic acid prevents bone loss in premenopausal women undergoing adjuvant chemotherapy for early-stage breast cancer. JClin Oncol 2008, 26:4739-4745.
    • (2008) JClin Oncol , vol.26 , pp. 4739-4745
    • Hershman, D.L.1    McMahon, D.J.2    Crew, K.D.3    Cremers, S.4    Irani, D.5    Cucchiara, G.6
  • 40
    • 76149130691 scopus 로고    scopus 로고
    • Prevention of bone loss by zoledronic acid in premenopausal women undergoing adjuvant chemotherapy persist up to one year following discontinuing treatment
    • Hershman D.L., McMahon D.J., Crew K.D., Shao T., Cremers S., Brafman L., et al. Prevention of bone loss by zoledronic acid in premenopausal women undergoing adjuvant chemotherapy persist up to one year following discontinuing treatment. JClin Endocrinol Metab 2010, 95:559-566.
    • (2010) JClin Endocrinol Metab , vol.95 , pp. 559-566
    • Hershman, D.L.1    McMahon, D.J.2    Crew, K.D.3    Shao, T.4    Cremers, S.5    Brafman, L.6
  • 41
    • 61449227421 scopus 로고    scopus 로고
    • Phase III randomized, placebo-controlled, double-blind trial of risedronate for the prevention of bone loss in premenopausal women undergoing chemotherapy for primary breast cancer
    • Hines S.L., Mincey B.A., Sloan J.A., Thomas S.P., Chottiner E., Loprinzi C.L., et al. Phase III randomized, placebo-controlled, double-blind trial of risedronate for the prevention of bone loss in premenopausal women undergoing chemotherapy for primary breast cancer. JClin Oncol 2009, 27:1047-1053.
    • (2009) JClin Oncol , vol.27 , pp. 1047-1053
    • Hines, S.L.1    Mincey, B.A.2    Sloan, J.A.3    Thomas, S.P.4    Chottiner, E.5    Loprinzi, C.L.6
  • 42
    • 77954277190 scopus 로고    scopus 로고
    • Economic evaluation of zoledronic acid for the prevention of osteoporotic fractures in postmenopausal women with early-stage breast cancer receiving aromatase inhibitors in the UK
    • Logman J.F.S., Heeg B.M.S., Botteman M.F., Kaura S., van Hout B.A. Economic evaluation of zoledronic acid for the prevention of osteoporotic fractures in postmenopausal women with early-stage breast cancer receiving aromatase inhibitors in the UK. Ann Oncol 2010, 21:1529-1536.
    • (2010) Ann Oncol , vol.21 , pp. 1529-1536
    • Logman, J.F.S.1    Heeg, B.M.S.2    Botteman, M.F.3    Kaura, S.4    van Hout, B.A.5
  • 44
    • 33744828376 scopus 로고    scopus 로고
    • Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]
    • Powles T., Paterson A., McCloskey E., Schein P., Scheffler B., Tidy A., et al. Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]. Breast Cancer Res 2006, 8:R13.
    • (2006) Breast Cancer Res , vol.8
    • Powles, T.1    Paterson, A.2    McCloskey, E.3    Schein, P.4    Scheffler, B.5    Tidy, A.6
  • 45
    • 56749165071 scopus 로고    scopus 로고
    • Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up
    • Diel I.J., Jaschke A., Solomayer E.F., Gollan C., Bastert G., Sohn C., et al. Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up. Ann Oncol 2008, 19:2007-2011.
    • (2008) Ann Oncol , vol.19 , pp. 2007-2011
    • Diel, I.J.1    Jaschke, A.2    Solomayer, E.F.3    Gollan, C.4    Bastert, G.5    Sohn, C.6
  • 46
    • 0035148170 scopus 로고    scopus 로고
    • Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial
    • Saarto T., Blomqvist C., Virkkunen P., Elomaa I. Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial. JClin Oncol 2001, 19:10-17.
    • (2001) JClin Oncol , vol.19 , pp. 10-17
    • Saarto, T.1    Blomqvist, C.2    Virkkunen, P.3    Elomaa, I.4
  • 47
    • 9444254706 scopus 로고    scopus 로고
    • Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients
    • Saarto T., Vehmanen L., Virkkunen P., Blomqvist C. Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients. Acta Oncol 2004, 43:650-656.
    • (2004) Acta Oncol , vol.43 , pp. 650-656
    • Saarto, T.1    Vehmanen, L.2    Virkkunen, P.3    Blomqvist, C.4
  • 48
    • 0028202499 scopus 로고
    • Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound
    • Green J.R., Muller K., Jaeggi K.A. Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound. JBone Miner Res 1994, 9:745-751.
    • (1994) JBone Miner Res , vol.9 , pp. 745-751
    • Green, J.R.1    Muller, K.2    Jaeggi, K.A.3
  • 49
    • 33646873043 scopus 로고    scopus 로고
    • Benefit of taxanes as adjuvant chemotherapy for early breast cancer: pooled analysis of 15,500 patients
    • Bria E., Nistico C., Cuppone F., Carlini P., Ciccarese M., Milella M., et al. Benefit of taxanes as adjuvant chemotherapy for early breast cancer: pooled analysis of 15,500 patients. Cancer 2006, 106:2337-2344.
    • (2006) Cancer , vol.106 , pp. 2337-2344
    • Bria, E.1    Nistico, C.2    Cuppone, F.3    Carlini, P.4    Ciccarese, M.5    Milella, M.6
  • 50
    • 34247516968 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network, Available at:, National Comprehensive Cancer Network, Fort Washington, PA, [accessed 27.06.11]
    • NCCN clinical practice guidelines in oncology: breast cancer. Version 2.2011 2011, National Comprehensive Cancer Network, Available at:, National Comprehensive Cancer Network, Fort Washington, PA, [accessed 27.06.11]. http://www.nccn.org/professionals/physician_gls/PDF/breast.pdf.
    • (2011) NCCN clinical practice guidelines in oncology: breast cancer. Version 2.2011
  • 51
    • 79959565208 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial
    • Gnant M., Mlineritsch B., Stoeger H., Luschin-Ebengreuth G., Heck D., Menzel C., et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol 2011, 12:631-641.
    • (2011) Lancet Oncol , vol.12 , pp. 631-641
    • Gnant, M.1    Mlineritsch, B.2    Stoeger, H.3    Luschin-Ebengreuth, G.4    Heck, D.5    Menzel, C.6
  • 52
    • 79953803585 scopus 로고    scopus 로고
    • Adjuvant treatment with zoledronic acid in stage II/III breast cancer.
    • The AZURE trial (BIG 01/04). Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, San Antonio, TX [Abstract S4-5].
    • Coleman RE, Thorpe HC, Cameron D, Dodwell D, Burkinshaw R, Keane M, etal. Adjuvant treatment with zoledronic acid in stage II/III breast cancer. The AZURE trial (BIG 01/04). Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX [Abstract S4-5].
    • (2010)
    • Coleman, R.E.1    Thorpe, H.C.2    Cameron, D.3    Dodwell, D.4    Burkinshaw, R.5    Keane, M.6
  • 53
    • 77950370156 scopus 로고    scopus 로고
    • The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer
    • Coleman R., Winter M., Cameron D., Bell R., Dodwell D., Keanne M., et al. The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer. Br J Cancer 2010, 102:1099-1105.
    • (2010) Br J Cancer , vol.102 , pp. 1099-1105
    • Coleman, R.1    Winter, M.2    Cameron, D.3    Bell, R.4    Dodwell, D.5    Keanne, M.6
  • 54
    • 61349156290 scopus 로고    scopus 로고
    • Zoledronic acid as adjuvant therapy for women with early stage breast cancer and disseminated tumor cells in bone marrow
    • [Abstract 559]
    • Lin A.Y., Park J.W., Scott J., Melisko M., Goga A., Moasser M.M., et al. Zoledronic acid as adjuvant therapy for women with early stage breast cancer and disseminated tumor cells in bone marrow. JClin Oncol 2008, 26(suppl.):20s. [Abstract 559].
    • (2008) JClin Oncol , vol.26 , Issue.SUPPL.
    • Lin, A.Y.1    Park, J.W.2    Scott, J.3    Melisko, M.4    Goga, A.5    Moasser, M.M.6
  • 55
    • 66349135597 scopus 로고    scopus 로고
    • Effect of zoledronate on persisting isolated tumor cells in the bone marrow of patients without recurrence of early breast cancer
    • [Abstract 511]
    • Rack B.K., Jueckstock J., Genss E.-M., Schoberth A., Schindlbeck C., Strobl B., et al. Effect of zoledronate on persisting isolated tumor cells in the bone marrow of patients without recurrence of early breast cancer. Breast Cancer Res Treat 2007, 106(suppl. 1):S40. [Abstract 511].
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL. 1
    • Rack, B.K.1    Jueckstock, J.2    Genss, E.-M.3    Schoberth, A.4    Schindlbeck, C.5    Strobl, B.6
  • 56
    • 77149122603 scopus 로고    scopus 로고
    • Influence of zoledronic acid on disseminated tumor cells (DTC) in primary breast cancer patients
    • [Abstract 2048]
    • Solomayer E.F., Gebauer G., Hirnle P., Janni W., Lück H.-J., Becker S., et al. Influence of zoledronic acid on disseminated tumor cells (DTC) in primary breast cancer patients. Cancer Res 2009, 69(suppl.):170s-171s. [Abstract 2048].
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Solomayer, E.F.1    Gebauer, G.2    Hirnle, P.3    Janni, W.4    Lück, H.-J.5    Becker, S.6
  • 57
    • 77952305169 scopus 로고    scopus 로고
    • Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial
    • Aft R., Naughton M., Trinkaus K., Watson M., Ylagan L., Chavez-Macgregor M., et al. Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial. Lancet Oncol 2010, 11:421-428.
    • (2010) Lancet Oncol , vol.11 , pp. 421-428
    • Aft, R.1    Naughton, M.2    Trinkaus, K.3    Watson, M.4    Ylagan, L.5    Chavez-Macgregor, M.6
  • 58
    • 0642342669 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer
    • Hillner B.E., Ingle J.N., Chlebowski R.T., Gralow J., Yee G.C., Janjan N.A., et al. American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer. JClin Oncol 2003, 21:4042-4057.
    • (2003) JClin Oncol , vol.21 , pp. 4042-4057
    • Hillner, B.E.1    Ingle, J.N.2    Chlebowski, R.T.3    Gralow, J.4    Yee, G.C.5    Janjan, N.A.6
  • 59
    • 69449090120 scopus 로고    scopus 로고
    • Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009
    • Goldhirsch A., Ingle J.N., Gelber R.D., Coates A.S., Thurlimann B., Senn H.-J. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Ann Oncol 2009, 20:1319-1329.
    • (2009) Ann Oncol , vol.20 , pp. 1319-1329
    • Goldhirsch, A.1    Ingle, J.N.2    Gelber, R.D.3    Coates, A.S.4    Thurlimann, B.5    Senn, H.-J.6
  • 60
    • 44649187408 scopus 로고    scopus 로고
    • Guidance for the management of breast cancer treatment-induced bone loss: a consensus position statement from a UK Expert Group
    • Reid D.M., Doughty J., Eastell R., Heys S.D., Howell A., McCloskey E.V., et al. Guidance for the management of breast cancer treatment-induced bone loss: a consensus position statement from a UK Expert Group. Cancer Treat Rev 2008, 34(suppl. 1):S3-S18.
    • (2008) Cancer Treat Rev , vol.34 , Issue.SUPPL. 1
    • Reid, D.M.1    Doughty, J.2    Eastell, R.3    Heys, S.D.4    Howell, A.5    McCloskey, E.V.6
  • 61
    • 34848874807 scopus 로고    scopus 로고
    • Management of cancer treatment-induced bone loss in early breast and prostate cancer - a consensus paper of the Belgian Bone Club
    • Body J.J., Bergmann P., Boonen S., Boutsen Y., Devogelaer J.P., Goemaere S., et al. Management of cancer treatment-induced bone loss in early breast and prostate cancer - a consensus paper of the Belgian Bone Club. Osteoporos Int 2007, 18:1439-1450.
    • (2007) Osteoporos Int , vol.18 , pp. 1439-1450
    • Body, J.J.1    Bergmann, P.2    Boonen, S.3    Boutsen, Y.4    Devogelaer, J.P.5    Goemaere, S.6
  • 62
    • 40149083563 scopus 로고    scopus 로고
    • Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel
    • Aapro M., Abrahamsson P.A., Body J.J., Coleman R.E., Colomer R., Costa L., et al. Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel. Ann Oncol 2008, 19:420-432.
    • (2008) Ann Oncol , vol.19 , pp. 420-432
    • Aapro, M.1    Abrahamsson, P.A.2    Body, J.J.3    Coleman, R.E.4    Colomer, R.5    Costa, L.6
  • 63
    • 84856357300 scopus 로고    scopus 로고
    • Recommendations of a Swiss expert group on the use of bisphosphonates in patients with solid tumors
    • Rochlitz C., Senn H.J., Betticher D., Helbling D., von Moos R., Pestalozzi B., et al. Recommendations of a Swiss expert group on the use of bisphosphonates in patients with solid tumors. Swiss Med Forum 2010, 10:562-564.
    • (2010) Swiss Med Forum , vol.10 , pp. 562-564
    • Rochlitz, C.1    Senn, H.J.2    Betticher, D.3    Helbling, D.4    von Moos, R.5    Pestalozzi, B.6
  • 64
    • 77954339261 scopus 로고    scopus 로고
    • Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Aebi S., Davidson T., Gruber G., Castiglione M. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010, 21(suppl. 5):v9-v14.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Aebi, S.1    Davidson, T.2    Gruber, G.3    Castiglione, M.4
  • 65
    • 79952743744 scopus 로고    scopus 로고
    • American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer
    • Van Poznak C.H., Temin S., Yee G.C., Janjan N.A., Barlow W.E., Biermann J.S., et al. American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. JClin Oncol 2011, 29:1221-1227.
    • (2011) JClin Oncol , vol.29 , pp. 1221-1227
    • Van Poznak, C.H.1    Temin, S.2    Yee, G.C.3    Janjan, N.A.4    Barlow, W.E.5    Biermann, J.S.6
  • 66
    • 0035700603 scopus 로고    scopus 로고
    • Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds
    • Kanis J.A., Johnell O., Oden A., Dawson A., De Laet C., Jonsson B. Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int 2001, 12:989-995.
    • (2001) Osteoporos Int , vol.12 , pp. 989-995
    • Kanis, J.A.1    Johnell, O.2    Oden, A.3    Dawson, A.4    De Laet, C.5    Jonsson, B.6
  • 67
  • 69
    • 3242728658 scopus 로고    scopus 로고
    • Ameta-analysis of previous fracture and subsequent fracture risk
    • Kanis J.A., Johnell O., De Laet C., Johansson H., Oden A., Delmas P., et al. Ameta-analysis of previous fracture and subsequent fracture risk. Bone 2004, 35:375-382.
    • (2004) Bone , vol.35 , pp. 375-382
    • Kanis, J.A.1    Johnell, O.2    De Laet, C.3    Johansson, H.4    Oden, A.5    Delmas, P.6
  • 71
    • 77954254610 scopus 로고    scopus 로고
    • National Osteoporosis Foundation, National Osteoporosis Foundation, Washington, DC, Available at:, [accessed 27.06.11]
    • Clinician's guide to prevention and treatment of osteoporosis 2010, National Osteoporosis Foundation, National Osteoporosis Foundation, Washington, DC, Available at:, [accessed 27.06.11]. http://www.nof.org/sites/default/files/pdfs/NOF_ClinicianGuide2009_v7.pdf.
    • (2010) Clinician's guide to prevention and treatment of osteoporosis
  • 72
    • 4143114883 scopus 로고    scopus 로고
    • Prevention and management of osteoporosis
    • World Health Organization, Technical Report Series
    • Prevention and management of osteoporosis. WHO 2003, 921:1-192. World Health Organization, Technical Report Series.
    • (2003) WHO , vol.921 , pp. 1-192
  • 73
    • 84856329240 scopus 로고    scopus 로고
    • FRAX® WHO fracture risk assessment tool. Web version 3.2. Sheffield, UK: World Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield; Available at: [accessed 27.06.11].
    • Kanis JA. FRAX® WHO fracture risk assessment tool. Web version 3.2. Sheffield, UK: World Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield; Available at: [accessed 27.06.11]. http://www.shef.ac.uk/FRAX/.
    • Kanis, J.A.1
  • 75
    • 74549130461 scopus 로고    scopus 로고
    • Management of osteoporosis in postmenopausal women: 2010 position statement of the North American Menopause Society
    • Management of osteoporosis in postmenopausal women: 2010 position statement of the North American Menopause Society. Menopause 2010, 17:25-54.
    • (2010) Menopause , vol.17 , pp. 25-54
  • 76
    • 0036728561 scopus 로고    scopus 로고
    • Exercise and lumbar spine bone mineral density in postmenopausal women: a meta-analysis of individual patient data
    • Kelley G.A., Kelley K.S., Tran Z.V. Exercise and lumbar spine bone mineral density in postmenopausal women: a meta-analysis of individual patient data. JGerontol A Biol Sci Med Sci 2002, 57:M599-M604.
    • (2002) JGerontol A Biol Sci Med Sci , vol.57
    • Kelley, G.A.1    Kelley, K.S.2    Tran, Z.V.3
  • 77
    • 68249134241 scopus 로고    scopus 로고
    • Effects of exercise vs bisphosphonates on bone mineral density in breast cancer patients receiving chemotherapy
    • Swenson K.K., Nissen M.J., Anderson E., Shapiro A., Schousboe J., Leach J. Effects of exercise vs bisphosphonates on bone mineral density in breast cancer patients receiving chemotherapy. JSupport Oncol 2009, 7:101-107.
    • (2009) JSupport Oncol , vol.7 , pp. 101-107
    • Swenson, K.K.1    Nissen, M.J.2    Anderson, E.3    Shapiro, A.4    Schousboe, J.5    Leach, J.6
  • 78
    • 0033519221 scopus 로고    scopus 로고
    • The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
    • Burgess T.L., Qian Y., Kaufman S., Ring B.D., Van G., Capparelli C., et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. JCell Biol 1999, 145:527-538.
    • (1999) JCell Biol , vol.145 , pp. 527-538
    • Burgess, T.L.1    Qian, Y.2    Kaufman, S.3    Ring, B.D.4    Van, G.5    Capparelli, C.6
  • 79
    • 54449084015 scopus 로고    scopus 로고
    • Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer
    • Ellis G.K., Bone H.G., Chlebowski R., Paul D., Spadafora S., Smith J., et al. Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer. JClin Oncol 2008, 26:4875-4882.
    • (2008) JClin Oncol , vol.26 , pp. 4875-4882
    • Ellis, G.K.1    Bone, H.G.2    Chlebowski, R.3    Paul, D.4    Spadafora, S.5    Smith, J.6
  • 80
    • 84856349601 scopus 로고    scopus 로고
    • US Department of Health and Human Services. Denosumab safety FDA analysis. Proceedings of the August 13, meeting of the Reproductive Health Drugs Advisory Committee. Available at: [accessed 27.06.11].
    • US Department of Health and Human Services. Denosumab safety FDA analysis. Proceedings of the August 13, 2009, meeting of the Reproductive Health Drugs Advisory Committee. Available at: [accessed 27.06.11]. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ReproductiveHealthDrugsAdvisoryCommittee/UCM179782.pdf.
    • (2009)
  • 81
    • 68049122822 scopus 로고    scopus 로고
    • Efficacy and safety of denosumab in postmenopausal women with osteopenia or osteoporosis: a systematic review and a meta-analysis
    • Anastasilakis A.D., Toulis K.A., Goulis D.G., Polyzos S.A., Delaroudis S., Giomisi A., et al. Efficacy and safety of denosumab in postmenopausal women with osteopenia or osteoporosis: a systematic review and a meta-analysis. Horm Metab Res 2009, 41:721-729.
    • (2009) Horm Metab Res , vol.41 , pp. 721-729
    • Anastasilakis, A.D.1    Toulis, K.A.2    Goulis, D.G.3    Polyzos, S.A.4    Delaroudis, S.5    Giomisi, A.6
  • 82
    • 78149409580 scopus 로고    scopus 로고
    • Increased risk of serious infections in women with osteopenia or osteoporosis treated with denosumab
    • Toulis K.A., Anastasilakis A.D. Increased risk of serious infections in women with osteopenia or osteoporosis treated with denosumab. Osteoporos Int 2010, 21:1963-1964.
    • (2010) Osteoporos Int , vol.21 , pp. 1963-1964
    • Toulis, K.A.1    Anastasilakis, A.D.2
  • 85
    • 84856349600 scopus 로고    scopus 로고
    • [Prolia, injection (denosumab)]. Swiss agency for therapeutic products. Available at: [accessed 27.06.11].
    • [Prolia, injection (denosumab)]. Swiss agency for therapeutic products. Available at: [accessed 27.06.11]. http://www.swissmedic.ch/zulassungen/00171/00181/01382/index.html%3Flang%3Den.
  • 86
    • 84856349602 scopus 로고    scopus 로고
    • Notice of decision for PrProlia™. Health Canada. Available at: [accessed 27.06.11].
    • Notice of decision for PrProlia™. Health Canada. Available at: [accessed 27.06.11]. http://www.hc-sc.gc.ca/dhp-mps/alt_formats/pdf/prodpharma/sbd-smd/phase1-decision/drug-med/nd_ad_2010_prolia_121139-eng.pdf.
  • 87
    • 5444262558 scopus 로고    scopus 로고
    • Bisphosphonates: clinical experience
    • Coleman R.E. Bisphosphonates: clinical experience. Oncologist 2004, 9(suppl. 4):14-27.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 4 , pp. 14-27
    • Coleman, R.E.1
  • 88
    • 0034162528 scopus 로고    scopus 로고
    • Pamidronate prevents skeletal complications and is effective palliative treatment in womenwith breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials
    • Lipton A., Theriault R.L., Hortobagyi G.N., Simeone J., Knight R.D., Mellars K., et al. Pamidronate prevents skeletal complications and is effective palliative treatment in womenwith breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials. Cancer 2000, 88:1082-1090.
    • (2000) Cancer , vol.88 , pp. 1082-1090
    • Lipton, A.1    Theriault, R.L.2    Hortobagyi, G.N.3    Simeone, J.4    Knight, R.D.5    Mellars, K.6
  • 89
    • 0034660098 scopus 로고    scopus 로고
    • Bisphosphonates and breast carcinoma: present and future
    • Lipton A. Bisphosphonates and breast carcinoma: present and future. Cancer 2000, 88:3033-3037.
    • (2000) Cancer , vol.88 , pp. 3033-3037
    • Lipton, A.1
  • 91
    • 7044226177 scopus 로고    scopus 로고
    • Assessment and treatment of patients with malignant spinal cord compression
    • 91; discussion follows
    • Abrahm J.L. Assessment and treatment of patients with malignant spinal cord compression. JSupport Oncol 2004, 2:377-388. 91; discussion follows.
    • (2004) JSupport Oncol , vol.2 , pp. 377-388
    • Abrahm, J.L.1
  • 92
    • 15744405991 scopus 로고    scopus 로고
    • Systematic review of the diagnosis and management of malignant extradural spinal cord compression: the Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group
    • Loblaw D.A., Perry J., Chambers A., Laperriere N.J. Systematic review of the diagnosis and management of malignant extradural spinal cord compression: the Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group. JClin Oncol 2005, 23:2028-2037.
    • (2005) JClin Oncol , vol.23 , pp. 2028-2037
    • Loblaw, D.A.1    Perry, J.2    Chambers, A.3    Laperriere, N.J.4
  • 93
    • 35048875471 scopus 로고    scopus 로고
    • Pathologic fractures correlate with reduced survival in patients with malignant bone disease
    • Saad F., Lipton A., Cook R., Chen Y.-M., Smith M., Coleman R. Pathologic fractures correlate with reduced survival in patients with malignant bone disease. Cancer 2007, 110:1860-1867.
    • (2007) Cancer , vol.110 , pp. 1860-1867
    • Saad, F.1    Lipton, A.2    Cook, R.3    Chen, Y.-M.4    Smith, M.5    Coleman, R.6
  • 94
    • 0027531814 scopus 로고
    • Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer
    • Paterson A.H., Powles T.J., Kanis J.A., McCloskey E., Hanson J., Ashley S. Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer. JClin Oncol 1993, 11:59-65.
    • (1993) JClin Oncol , vol.11 , pp. 59-65
    • Paterson, A.H.1    Powles, T.J.2    Kanis, J.A.3    McCloskey, E.4    Hanson, J.5    Ashley, S.6
  • 96
    • 17144447171 scopus 로고    scopus 로고
    • Intravenous ibandronate reduces the incidence of skeletal complications inpatients with breast cancer and bone metastases
    • Body J.-J., Diel I.J., Lichinitser M.R., Kreuser E.D., Dornoff W., Gorbunova V.A., et al. Intravenous ibandronate reduces the incidence of skeletal complications inpatients with breast cancer and bone metastases. Ann Oncol 2003, 14:1399-1405.
    • (2003) Ann Oncol , vol.14 , pp. 1399-1405
    • Body, J.-J.1    Diel, I.J.2    Lichinitser, M.R.3    Kreuser, E.D.4    Dornoff, W.5    Gorbunova, V.A.6
  • 97
    • 1942501727 scopus 로고    scopus 로고
    • Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studies
    • Body J.J., Diel I.J., Lichinitzer M., Lazarev A., Pecherstorfer M., Bell R., et al. Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studies. Br J Cancer 2004, 90:1133-1137.
    • (2004) Br J Cancer , vol.90 , pp. 1133-1137
    • Body, J.J.1    Diel, I.J.2    Lichinitzer, M.3    Lazarev, A.4    Pecherstorfer, M.5    Bell, R.6
  • 98
    • 10744233021 scopus 로고    scopus 로고
    • Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial
    • Rosen L.S., Gordon D., Kaminski M., Howell A., Belch A., Mackey J., et al. Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial. Cancer 2003, 98:1735-1744.
    • (2003) Cancer , vol.98 , pp. 1735-1744
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3    Howell, A.4    Belch, A.5    Mackey, J.6
  • 99
    • 84856358880 scopus 로고    scopus 로고
    • Continuing benefit of zoledronic acid for the prevention of skeletal complications in breast cancer patients with bone metastases.
    • Presented at: The 9th St. Gallen International Consensus Conference on Primary Therapy of Early Breast Cancer; January 26-29, St. Gallen, Switzerland [Abstract 104].
    • Zheng M, Rosen L, Gordon D, Kaminski M, Howell A, Belch A, etal. Continuing benefit of zoledronic acid for the prevention of skeletal complications in breast cancer patients with bone metastases. Presented at: The 9th St. Gallen International Consensus Conference on Primary Therapy of Early Breast Cancer; January 26-29, 2005; St. Gallen, Switzerland [Abstract 104].
    • (2005)
    • Zheng, M.1    Rosen, L.2    Gordon, D.3    Kaminski, M.4    Howell, A.5    Belch, A.6
  • 100
    • 47149097084 scopus 로고    scopus 로고
    • Breast cancer patients without pain are at risk for skeletal-related events and may have better outcomes with zoledronic acid compared with pamidronate.
    • Presented at: 29th Annual San Antonio Breast Cancer Symposium; December 14-17, San Antonio, TX [Abstract 1071].
    • Costa L, Chen Y-M. Breast cancer patients without pain are at risk for skeletal-related events and may have better outcomes with zoledronic acid compared with pamidronate. Presented at: 29th Annual San Antonio Breast Cancer Symposium; December 14-17, 2006; San Antonio, TX [Abstract 1071].
    • (2006)
    • Costa, L.1    Chen, Y.-M.2
  • 101
    • 77950117427 scopus 로고    scopus 로고
    • Bisphosphonates for the relief of pain secondary to bone metastases
    • Wong R., Wiffen P.J. Bisphosphonates for the relief of pain secondary to bone metastases. Cochrane Database Syst Rev 2002, CD002068.
    • (2002) Cochrane Database Syst Rev
    • Wong, R.1    Wiffen, P.J.2
  • 102
    • 20644449488 scopus 로고    scopus 로고
    • Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial
    • Kohno N., Aogi K., Minami H., Nakamura S., Asaga T., Iino Y., et al. Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial. JClin Oncol 2005, 23:3314-3321.
    • (2005) JClin Oncol , vol.23 , pp. 3314-3321
    • Kohno, N.1    Aogi, K.2    Minami, H.3    Nakamura, S.4    Asaga, T.5    Iino, Y.6
  • 103
    • 20344387828 scopus 로고    scopus 로고
    • Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration
    • Wardley A., Davidson N., Barrett-Lee P., Hong A., Mansi J., Dodwell D., et al. Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration. Br J Cancer 2005, 92:1869-1876.
    • (2005) Br J Cancer , vol.92 , pp. 1869-1876
    • Wardley, A.1    Davidson, N.2    Barrett-Lee, P.3    Hong, A.4    Mansi, J.5    Dodwell, D.6
  • 104
    • 4444337297 scopus 로고    scopus 로고
    • Oral ibandronate improves bone pain and preserves quality of life in patients with skeletal metastases due to breast cancer
    • Body J.-J., Diel I.J., Bell R., Pecherstorfer M., Lichinitser M.R., Lazarev A.F., et al. Oral ibandronate improves bone pain and preserves quality of life in patients with skeletal metastases due to breast cancer. Pain 2004, 111:306-312.
    • (2004) Pain , vol.111 , pp. 306-312
    • Body, J.-J.1    Diel, I.J.2    Bell, R.3    Pecherstorfer, M.4    Lichinitser, M.R.5    Lazarev, A.F.6
  • 105
    • 78649942965 scopus 로고    scopus 로고
    • Loading dose ibandronate in rapid pain management of metastatic bone disease (MBD)
    • [Abstract 18580]
    • Pendharkar D., Goyal H. Loading dose ibandronate in rapid pain management of metastatic bone disease (MBD). JClin Oncol 2006, 24(suppl.):694s. [Abstract 18580].
    • (2006) JClin Oncol , vol.24 , Issue.SUPPL.
    • Pendharkar, D.1    Goyal, H.2
  • 106
    • 0036393344 scopus 로고    scopus 로고
    • Ibandronate in the treatment of prostate cancer associated painful osseous metastases
    • Heidenreich A., Elert A., Hofmann R. Ibandronate in the treatment of prostate cancer associated painful osseous metastases. Prostate Cancer Prostatic Dis 2002, 5:231-235.
    • (2002) Prostate Cancer Prostatic Dis , vol.5 , pp. 231-235
    • Heidenreich, A.1    Elert, A.2    Hofmann, R.3
  • 107
    • 4444327076 scopus 로고    scopus 로고
    • Efficacy and safety of ibandronate in the treatment of opioid-resistant bone pain associated with metastatic bone disease: a pilot study
    • Mancini I., Dumon J.C., Body J.J. Efficacy and safety of ibandronate in the treatment of opioid-resistant bone pain associated with metastatic bone disease: a pilot study. JClin Oncol 2004, 22:3587-3592.
    • (2004) JClin Oncol , vol.22 , pp. 3587-3592
    • Mancini, I.1    Dumon, J.C.2    Body, J.J.3
  • 108
    • 46949100735 scopus 로고    scopus 로고
    • Exploring the anti-tumour activity ofbisphosphonates in early breast cancer
    • Winter M.C., Holen I., Coleman R.E. Exploring the anti-tumour activity ofbisphosphonates in early breast cancer. Cancer Treat Rev 2008, 34:453-475.
    • (2008) Cancer Treat Rev , vol.34 , pp. 453-475
    • Winter, M.C.1    Holen, I.2    Coleman, R.E.3
  • 109
    • 11144254409 scopus 로고    scopus 로고
    • Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells
    • Neville-Webbe H.L., Rostami-Hodjegan A., Evans C.A., Coleman R.E., Holen I. Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. Int J Cancer 2005, 113:364-371.
    • (2005) Int J Cancer , vol.113 , pp. 364-371
    • Neville-Webbe, H.L.1    Rostami-Hodjegan, A.2    Evans, C.A.3    Coleman, R.E.4    Holen, I.5
  • 110
    • 0034660097 scopus 로고    scopus 로고
    • Markers of bone turnover in bone metastases
    • Fontana A., Delmas P.D. Markers of bone turnover in bone metastases. Cancer 2000, 88:2952-2960.
    • (2000) Cancer , vol.88 , pp. 2952-2960
    • Fontana, A.1    Delmas, P.D.2
  • 111
    • 24644479228 scopus 로고    scopus 로고
    • Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
    • Coleman R.E., Major P., Lipton A., Brown J.E., Lee K.A., Smith M., et al. Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. JClin Oncol 2005, 23:4925-4935.
    • (2005) JClin Oncol , vol.23 , pp. 4925-4935
    • Coleman, R.E.1    Major, P.2    Lipton, A.3    Brown, J.E.4    Lee, K.A.5    Smith, M.6
  • 112
    • 35548960086 scopus 로고    scopus 로고
    • Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity
    • Lipton A., Cook R.J., Major P., Smith M.R., Coleman R.E. Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity. Oncologist 2007, 12:1035-1043.
    • (2007) Oncologist , vol.12 , pp. 1035-1043
    • Lipton, A.1    Cook, R.J.2    Major, P.3    Smith, M.R.4    Coleman, R.E.5
  • 113
    • 47149118386 scopus 로고    scopus 로고
    • Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid
    • Lipton A., Cook R., Saad F., Major P., Garnero P., Terpos E., et al. Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid. Cancer 2008, 113:193-201.
    • (2008) Cancer , vol.113 , pp. 193-201
    • Lipton, A.1    Cook, R.2    Saad, F.3    Major, P.4    Garnero, P.5    Terpos, E.6
  • 114
    • 25844513080 scopus 로고    scopus 로고
    • Cost-effectiveness of oral ibandronate versus IV zoledronic acid or IV pamidronate for bone metastases in patients receiving oral hormonal therapy for breast cancer in the United Kingdom
    • De Cock E., Hutton J., Canney P., Body J.J., Barrett-Lee P., Neary M.P., et al. Cost-effectiveness of oral ibandronate versus IV zoledronic acid or IV pamidronate for bone metastases in patients receiving oral hormonal therapy for breast cancer in the United Kingdom. Clin Ther 2005, 27:1295-1310.
    • (2005) Clin Ther , vol.27 , pp. 1295-1310
    • De Cock, E.1    Hutton, J.2    Canney, P.3    Body, J.J.4    Barrett-Lee, P.5    Neary, M.P.6
  • 115
    • 18844440666 scopus 로고    scopus 로고
    • Costs and consequences of using pamidronate compared with zoledronic acid in the management of breast cancer patients in the UK
    • Guest J.F., Clegg J.P., Davie A.M., McCloskey E. Costs and consequences of using pamidronate compared with zoledronic acid in the management of breast cancer patients in the UK. Curr Med Res Opin 2005, 21:805-815.
    • (2005) Curr Med Res Opin , vol.21 , pp. 805-815
    • Guest, J.F.1    Clegg, J.P.2    Davie, A.M.3    McCloskey, E.4
  • 116
    • 33745622153 scopus 로고    scopus 로고
    • Cost effectiveness of bisphosphonates in the management of breast cancer patients with bone metastases
    • Botteman M., Barghout V., Stephens J., Hay J., Brandman J., Aapro M. Cost effectiveness of bisphosphonates in the management of breast cancer patients with bone metastases. Ann Oncol 2006, 17:1072-1082.
    • (2006) Ann Oncol , vol.17 , pp. 1072-1082
    • Botteman, M.1    Barghout, V.2    Stephens, J.3    Hay, J.4    Brandman, J.5    Aapro, M.6
  • 117
    • 45149127283 scopus 로고    scopus 로고
    • Cost-effectiveness of oral clodronate compared with oral ibandronate, intravenous zoledronate or intravenous pamidronate in breast cancer patients
    • Paterson A., McCloskey E., Redzepovic J., Ott I., Gust R. Cost-effectiveness of oral clodronate compared with oral ibandronate, intravenous zoledronate or intravenous pamidronate in breast cancer patients. JInt Med Res 2008, 36:400-413.
    • (2008) JInt Med Res , vol.36 , pp. 400-413
    • Paterson, A.1    McCloskey, E.2    Redzepovic, J.3    Ott, I.4    Gust, R.5
  • 118
    • 84856329239 scopus 로고    scopus 로고
    • Cost-effectiveness of zoledronic acid (ZOL) versus denosumab (Dmab) in prevention of skeletal-related events (SREs) in metastatic breast cancer (mBC).
    • Presented at: 2011 ASCO Annual Meeting; June 3-7, 2011; Chicago, IL [Abstract 9025].
    • Carter JA, Snedecor SJ, Kaura S, Botteman MF. Cost-effectiveness of zoledronic acid (ZOL) versus denosumab (Dmab) in prevention of skeletal-related events (SREs) in metastatic breast cancer (mBC). Presented at: 2011 ASCO Annual Meeting; June 3-7, 2011; Chicago, IL [Abstract 9025].
    • Carter, J.A.1    Snedecor, S.J.2    Kaura, S.3    Botteman, M.F.4
  • 119
    • 79551568488 scopus 로고    scopus 로고
    • Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study
    • Stopeck A.T., Lipton A., Body J.J., Steger G.G., Tonkin K., de Boer R.H., et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. JClin Oncol 2010, 28:5132-5139.
    • (2010) JClin Oncol , vol.28 , pp. 5132-5139
    • Stopeck, A.T.1    Lipton, A.2    Body, J.J.3    Steger, G.G.4    Tonkin, K.5    de Boer, R.H.6
  • 121
    • 84856358879 scopus 로고    scopus 로고
    • Denosumab to prolong bone metastasis-free survival in men with castrate-resistant prostate cancer
    • results of a global phase 3, randomized, double-blind trial. Plenary Presentation at: AUA Annual Meeting; May 14-19, 2011; Washington, DC.
    • Smith MR, Saad F, Coleman R, Shore N, Fizazi K, Tombal B, etal. Denosumab to prolong bone metastasis-free survival in men with castrate-resistant prostate cancer: results of a global phase 3, randomized, double-blind trial. Plenary Presentation at: AUA Annual Meeting; May 14-19, 2011; Washington, DC.
    • Smith, M.R.1    Saad, F.2    Coleman, R.3    Shore, N.4    Fizazi, K.5    Tombal, B.6
  • 122
    • 33947510501 scopus 로고    scopus 로고
    • Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98
    • Coates A.S., Keshaviah A., Thurlimann B., Mouridsen H., Mauriac L., Forbes J.F., et al. Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98. JClin Oncol 2007, 25:486-492.
    • (2007) JClin Oncol , vol.25 , pp. 486-492
    • Coates, A.S.1    Keshaviah, A.2    Thurlimann, B.3    Mouridsen, H.4    Mauriac, L.5    Forbes, J.F.6
  • 123
    • 77949541181 scopus 로고    scopus 로고
    • Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells invitro: evidence of synergistic interaction
    • Neville-Webbe H.L., Coleman R.E., Holen I. Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells invitro: evidence of synergistic interaction. Br J Cancer 2010, 102:1010-1017.
    • (2010) Br J Cancer , vol.102 , pp. 1010-1017
    • Neville-Webbe, H.L.1    Coleman, R.E.2    Holen, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.