Can a standard dose of eicosapentaenoic acid (EPA) supplementation reduce the symptoms of delayed onset of muscle soreness?

Journal of the International Society of Sports Nutrition

Volumn 9, Issue , 2012, Pages

  Houghton, David ^a,b   Onambele, Gladys L ^a  

^a MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^b Institute for Cell and Molecular Biosciences   (United Kingdom)

Author keywords

EPA; IL 6; Resistance exercise and delayed onset muscle soreness

Indexed keywords

EID: 84856319445     PISSN: None     EISSN: 15502783     Source Type: Journal    
DOI: 10.1186/1550-2783-9-2     Document Type: Article

References (37)

1. MacIntyre DL, Sorichter S, Mair J, Berg A, McKenzie DC. Markers of inflammation and myofibrillar proteins following eccentric exercise in humans. Eur J Appl Physiol 2001, 84(3):180-6. 10.1007/s004210170002, 11320633.
2. Smith LL, Anwar A, Fragen M, Rananto C, Johnson R, Holbert D. Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise. Eur J Appl Physiol 2000, 82(1-2):61-7. 10.1007/s004210050652, 10879444.
3. Lenn J, Uhl T, Mattacola C, Boissonneault G, Yates J, Ibrahim W, Bruckner G. The effects of fish oil and isoflavones on delayed onset muscle soreness. Med Sci Sports Exerc 2002, 34(10):1605-13. 10.1097/00005768-200210000-00012, 12370562.
4. Armstrong RB. Initial events in exercise-induced muscular injury. Med Sci Sports Exerc 1990, 22(4):429-35.
5. Vierck J, O'Reilly B, Hossner K, Antonio J, Byrne K, Bucci L, Dodson M. Satellite cell regulation following myotrauma caused by resistance exercise. Cell Biol Int 2000, 24(5):263-72. 10.1006/cbir.2000.0499, 10805959.
6. Asmussen E. Observations on experimental muscular soreness. Acta Rheumatol Scand 1956, 2(2):109-16.
7. Graven-Nielsen T, Svensson P, Arendt-Nielsen L. Effects of experimental muscle pain on muscle activity and co-ordination during static and dynamic motor function. Electroencephalogr Clin Neurophysiol 1997, 105(2):156-64. 10.1016/S0924-980X(96)96554-6, 9152211.
8. Croisier JL, Camus G, Venneman I, Deby-Dupont G, Juchmès-Ferir A, Lamy M, Crielaard JM, Deby C, Duchateau J. Effects of training on exercise induced muscle damage and interleukin06 production. Muscle and Nerve 1998, 22:208-212.
9. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol 1999, 515(Pt 1):287-91. 2269132, 9925898.
10. Tidball JG. Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol 2005, 288(2):R345-53.
11. Richards CD, Gaulder J. Role of cytokines in the acute phase response. Human cytokines: their role in disease and therapy 1998, Cambridge: Blackwell Science.
12. Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, Achong MK. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. Journal of Clinical Investigation 1998, 101(2):311-20. 10.1172/JCI1368, 508569, 9435302.
13. Northoff H, Berg A. Immunologic mediators as parameters of the reaction to strenuous exercise. Int J Sports Med 1991, 12(Suppl 1):S9-15.
14. Pedersen BK, Toft AD. Effects of exercise on lymphocytes and cytokines. Br J Sports Med 2000, 34(4):246-51. 10.1136/bjsm.34.4.246, 1724218, 10953894.
15. Baumann H, Gauldie J. The acute phase response. Immunol Today 1994, 15(2):74-80. 10.1016/0167-5699(94)90137-6, 7512342.
16. Febbraio MA, Pedersen BK. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 2002, 16(11):1335-47. 10.1096/fj.01-0876rev, 12205025.
17. Al-Shanti N, Saini A, Faulkner SH, Stewart CE. Beneficial synergistic interactions of TNF-alpha and IL-6 in C2 skeletal myoblasts--potential cross-talk with IGF system. Growth Factors 2008, 26(2):61-73. 10.1080/08977190802025024, 18428025.
18. Magee P, Pearson S, Allen J. The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation. Lipids Health Dis 2008, 7:1-24. 10.1186/1476-511X-7-1, 2265705, 18226198.
19. Matsuyama W, Mitsuyama H, Watanabe M, Oonakahara K, Higashimoto I, Osame M, Arimura K. Effects of omega-3 polyunsaturated fatty acids on inflammatory markers in COPD. Chest 2005, 128(6):3817-27. 10.1378/chest.128.6.3817, 16354850.
20. Phillips T, Childs AC, Dreon DM, Phinney S, Leeuwenburgh C. A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Med Sci Sports Exerc 2003, 35(12):2032-7. 10.1249/01.MSS.0000099112.32342.10, 14652498.
21. Bloomer RJ, Larson DE, Fisher-Wellman KH, Galpin AJ, Schilling BK. Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study. Lipids Health Dis 2009, 8:36. 10.1186/1476-511X-8-36, 2735747, 19691834.
22. Burgess KE, Pearson SJ, Onambele GL. Patellar tendon properties with fluctuating menstrual cycle hormones. Journal of Strength & Conditioning Research 2010, 24(8):2088-95. 10.1519/JSC.0b013e3181aeb12b, 3269009, 22303416.
23. Zazulak BT, Paterno M, Myer GD, Romani WA, Hewett TE. The effects of the menstrual cycle on anterior knee laxity: a systematic review. Sports Medicine 2006, 36(10):847-62. 10.2165/00007256-200636100-00004, 17004848.
24. Phillips SK, Sanderson AG, Birch K, Bruce SA, Woledge RC. Changes in maximal voluntary force of human adductor pollicis muscle during the menstrual cycle. Journal of Physiology 1996, 496(Pt 2):551-7. 1160898, 8910237.
25. Pearson SJ, Onambele GN. Influence of time of day on tendon compliance and estimations of voluntary activation levels. Muscle & Nerve 2006, 33(6):792-800. 10.1002/mus.20529, 3267759, 22303472.
26. Melhim AF. Investigation of circadian rhythms in peak power and mean power of female physical education students. Int J Sports Med 1993, 14(6):303-6. 10.1055/s-2007-1021182, 8407059.
27. Tanriverdi F, Karaca Z, Unluhizarci K, Kelestimur F. The hypothalamo-pituitary-adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome. Stress 2007, 10(1):13-25. 10.1080/10253890601130823, 17454963.
28. Brown SJ, Child RB, Day SH, Donnelly AE. Exercise-induced skeletal muscle damage and adaptation following repeated bouts of eccentric muscle contractions. J Sports Sci 1997, 15(2):215-22. 10.1080/026404197367498, 9258852.
29. Babcock T, Helton WS, Espat NJ. Eicosapentaenoic acid (EPA): an antiinflammatory omega-3 fat with potential clinical applications. Nutrition 2000, 16(11-12):1116-8. 10.1016/S0899-9007(00)00392-0, 11118844.
30. Endres S, Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, van der Meer JW, Cannon JG, Rogers TS, Klempner MS, Weber PC, Schaefer EJ, Wolff SM, Dinarello CA. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989, 320(5):265-71. 10.1056/NEJM198902023200501, 2783477.
31. Lo CJ, Chiu KC, Fu M, Lo R, Helton S. Fish oil decreases macrophage tumor necrosis factor gene transcription by altering the NF kappa B activity. J Surg Res 1999, 82(2):216-21. 10.1006/jsre.1998.5524, 10090832.
32. Morrissey MC, Harman EA, Johnson MJ. Resistance training modes: specificity and effectiveness. Medicine & Science in Sports & Exercise 1995, 27(5):648-60. 3269424, 22303496.
33. Liao P, Zhou J, Ji LL, Zhang Y. Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-alpha. Am J Physiol Regul Integr Comp Physiol 2009, 298(3):R599-607.
34. Willett W. Commentary: Dietary diaries versus food frequency questionnaires-a case of undigestible data. Int J Epidemiol 2001, 30(2):317-9. 10.1093/ije/30.2.317, 11369736.
35. Caughey GE. The effect on human tumour necrosis factor α and interleukin 1 production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition 1995, 63:116-122.
36. Hellsten Y, Frandsen U, Orthenblad N, Sjødin B, Richter EA. Xanthine oxidase in human skeletal muscle following eccentric exercise: a role in inflammation. J Physiol 1997, 498(Pt 1):239-48. 1159248, 9023782.
37. Steensberg A, Keller C, Starkie RL, Osada T, Febbraio MA, Pedersen BK. IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab 2002, 283(6):E1272-8.