Phosphodiesterase I-inhibiting Diels-Alder adducts from the leaves of morus mesozygia

Planta Medica

Volumn 78, Issue 2, 2012, Pages 154-159

  Fozing, Christian D A ^a,b   Ali, Zulfiqar ^b,c   Ngadjui, Bonaventure T ^a   Choudhary, M Iqbal ^b,d   Kapche, Gilbert D W F ^a   Abegaz, Berhanu M ^e   Khan, Ikhlas A ^c  

^a UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c UNIVERSITY OF MISSISSIPPI   (United States)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e UNIVERSITY OF BOTSWANA   (Botswana)

Author keywords

(+) dimethylsmoracin O; Diels Alder adducts; mesozygins AC; Moraceae; Morus mesozygia; phosphodiesterase I inhibition

Indexed keywords

ARTONIN I; CHALCOMARACIN; DIMETHYLSMORACIN O; MESOZYGIN A; MESOZYGIN B; MESOZYGIN C; MORACHALCONE A; MORACIN C; MORACIN L; MORACIN M; MORUS MESOZYGIA EXTRACT; MULBERROFURAN F; NORARTOCARPETIN; PHOSPHODIESTERASE I; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; MEDICINAL PLANT; MORUS MESOZYGIA; PLANT LEAF; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; BENZOFURANS; MOLECULAR STRUCTURE; MORUS; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITORS; PLANT EXTRACTS; PLANT LEAVES; SNAKE VENOMS; SNAKES;

ALNUS; MORACEAE; MORUS (ANGIOSPERM);

EID: 84856303622     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280338     Document Type: Article

References (27)

1. Fashing P J. Feeding ecology of guereza in the Kakamega forest, Kenya: the importance of Moraceae fruit in their diet. Int J Primatol 2001 22 579-609 (Pubitemid 32665259)
2. Amala S. Management of diabetes in African traditional medicines, traditional herbal medicines for modern times: antidiabetic plants. New York CRC Press 2006 214-215
3. Burkill H M. The useful plants of west tropical Africa: Families M R. Vol. 4 Richmond Royal Botanic Gardens Kew 1997 969
4. Kapche G D. W. F., Fozing D C., Donfack J H., Fotso G W., Amadou D, Tchana A N., Bezabih M, Moundipa P F., Ngadjui B T., Abegaz B M. Prenylated arybenzofuran derivatives from Morus mesozygia with antioxidant activity. Phytochemistry 2009 70 216-221
5. Kuete V, Fozing D C., Kapche G D. W. F., Mbaveng A T., Kuiate J R., Ngadjui B T., Abegaz B M. Antimicrobial activity of the methanolic extract and compounds from Morus mesozygia stem bark. J Ethnopharmacol 2009 124 551-555
6. Kapche G D. W. F., Amadou D, Waffo-Teguo P, Donfack J H., Fozing C D., Harakat D, Tchana A N., Mérillon J M., Moundipa P F., Ngadjui B T., Abegaz B M. Hepatoprotective and antioxidant arylbenzofurans and flavonoids from the twigs of Morus mesozygia. Planta Med 2011 77 1044-1047
7. Choudhary M I., Fatima N, Abbasi M A., Jalil S, Ahmad V U., Atta-ur-Rahman. Phenolic glyscosides, a new class of human recombinant nucleotide pyrophosphatase phosphodiesterase-1 inhibitors. Bioorg Med Chem 2004 12 5793-5798 (Pubitemid 39388178)
8. Ahmad V U., Abbasi M A., Hussain H, Akhtar M N., Farooq U, Fatima N, Choudhary M I. Phenolic glycosides from Symplocos racemosa: natural inhibitors of phosphodiesterase. Phytochemistry 2003 63 217-220 (Pubitemid 36560141)
9. Peluso M R. Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver. Exp Biol Med 2006 231 1287-1299 (Pubitemid 44330564)
10. Dat N T., Jin X, Lee K, Hong Y S., Kim Y H., Lee J J. Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived Diels-Alder adducts from Morus species. J Nat Prod 2009 72 39-43
11. Arnone A, Assante G, Bava A, Dallavalle S, Nasini S, Acremines H. Novel prenylated polyketide metabolites produced by a strain of Acremonium byssoides. Tetrahedron 2009 65 786-791
12. Su C R., Kuo P C., Wang M L., Liou M J., Damu A G., Wu T S. Acetophenone derivatives from Acronychia pedunculata. J Nat Prod 2003 66 990-993 (Pubitemid 36909850)
13. Torres-Valencia J M., Chávez-R?os O E., Cerda-Garc?a-Rojas C M., Burgueño-Tapia E, Joseph-Nathan P. Dihydrofurochromones from Prionosciadium thapsoides. J Nat Prod 2008 71 1956-1960
14. Ferrari F, Monache F D. Constituents of Morus multicaulis roots. Fitoterapia 1998 69 554-555
15. Xia Y, Jin Y, Kaur N, Choi Y, Lee K. HIF-1 inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem 2011 46 2386-2396
16. Zhang Q J., Tang Y B., Chen R Y., Yu D Q. Three new cytotoxic Diels-Alder type adducts from Morus australis. Chem Biodivers 2007 4 1533-1540
17. Hano Y, Suzuki S, Kohno H, Nomura T. Absolute configuration of kuwanon L, a natural Diels-Alder type adduct from the Morus root bark. Heterocycles 1988 27 75-81
18. Hano Y, Suzuki S, Nomura T, Iitaka Y. Absolute configuration of natural Diels-Alder type adducts from the Morus root bark. Heterocycles 1988 27 2315-2324
19. Hano Y, Aida M, Nomura T, Ueda S. A novel way of determining the structure of artonin I, an optically active Diels-Alder type adduct, with the aid of an enzyme of Morus alba cultures. J Chem Soc Chem Commun 1992 1177-1178
20. Takasugi M, Nagao S, Masamune T, Shirata A, Takahashi K. Chalcomoracin, a natural Diels-Alder adduct from diseased mulberry. Chem Lett 1980 9 1573-1576
21. Lin C, Lu C, Huang P. Flavonoids from Artocarpus heterophyllus. Phytochemistry 1995 39 1447-1451
22. Matsuyama S, Kuwahara Y, Suzuki T. A new 2-arylbenzofuran, -hydroxymoracin N, from mulberry leaves. Agric Biol Chem 1991 55 1409-1410
23. Matsuyama S, Kuwahara Y, Nakamura S, Suzuki T. Oviposition stimulants for the lesser mulberry pyralid, Glyphodes pyloalis (Walker), in mulberry leaves; rediscovery of phytoalexin components as insect kairomones. Agric Biol Chem 1991 55 1333-1341
24. Fukai T, Hano Y, Hirakura K, Nomura T, Uzawa J, Fukushima K. Structures of two natural hypotensive Diels-Alder type adducts, mulberrofurans F and G, from the cultivated mulberry tree (Morus ihou Koidz.). Chem Pharm Bull 1985 33 3195-3204 (Pubitemid 16221839)
25. Basnet P, Kadota S, Terashima S, Shimizu M, Namba T. Two new 2-arylbenzofuran derivatives from hypoglycemic activity-bearing fractions of Morus insignis. Chem Pharm Bull 1993 41 1238-1243 (Pubitemid 23279401)
26. Takasugi M, Nagao S, Ueno S, Masamune T, Shirata A, Takahashi K. Studies on phytoalexins of the Moraceae. 2. Moracins C and D, new phytoalexins from diseased mulberry. Chem Lett 1978 7 1239-1240
27. Gunawan C, Rizzacasa M A. Mulberry Diels-Alder adducts: synthesis of chalcomoracin and mulberrofuran C methyl ethers. Org Lett 2010 12 1388-1391