A pseudokinase debut at the mycobacterial cell wall

Science Signaling

Volumn 5, Issue 208, 2012, Pages

  Warner, Digby F ^a,b   Mizrahi, Valerie ^a,b  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; MEMBRANE PROTEIN; MVIN PSEUDOKINASE; PEPTIDOGLYCAN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; PKNB PROTEIN, MYCOBACTERIUM TUBERCULOSIS;

BACTERIAL CELL WALL; BACTERIAL VIRULENCE; CATALYSIS; CELL MEMBRANE; CELL METABOLISM; CELL STRUCTURE; CRYSTAL STRUCTURE; ELECTRON TOMOGRAPHY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HOMEOSTASIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL WALL; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION;

MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; BACTERIAL PROTEINS; CELL WALL; HUMANS; MYCOBACTERIUM TUBERCULOSIS; PEPTIDOGLYCAN; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 84856294953     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002785     Document Type: Review

References (20)

1. M. Niederweis, O. Danilchanka, J. Huff, C. Hoffmann, H. Engelhardt, Mycobacterial outer membranes: In search of proteins. Trends Microbiol. 18, 109-116 (2010).
2. S. Bhamidi, M. S. Scherman, V. Jones, D. C. Crick, J. T. Belisle, P. J. Brennan, M. R. McNeil, Detailed structural and quantitative analysis reveals the spatial organization of the cell walls of in vivo grown Mycobacterium leprae and in vitro grown Mycobacterium tuberculosis. J. Biol. Chem. 286, 23168-23177 (2011).
3. B. Boitel, M. Ortiz-Lombardía, R. Durán, F. Pompeo, S. T. Cole, C. Cerveñansky, P. M. Alzari, PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol. Microbiol. 49, 1493-1508 (2003).
4. A. Koul, E. Arnoult, N. Lounis, J. Guillemont, K. Andries, The challenge of new drug discovery for tuberculosis. Nature 469, 483-490 (2011).
5. S. T. Cole, R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S. V. Gordon, K. Eiglmeier, S. Gas, C. E. Barry, 3rd, F. Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. Gentles, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, A. Krogh, J. McLean, S. Moule, L. Murphy, K. Oliver, J. Osborne, M. A. Quail, M. A. Rajandream, J. Rogers, S. Rutter, K. Seeger, J. Skelton, R. Squares, S. Squares, J. E. Sulston, K. Taylor, S. Whitehead, B. G. Barrell, Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544 (1998).
6. V. Molle, L. Kremer, Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way. Mol. Microbiol. 75, 1064-1077 (2010).
7. J. Chao, D. Wong, X. Zheng, V. Poirier, H. Bach, Z. Hmama, Y. Av-Gay, Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis. Biochim. Biophys. Acta 1804, 620-627 (2010).
8. C. L. Gee, K. G. Papavinasasundaram, S. R. Blair, C. E. Baer, A. M. Falick, D. S. King, J. E. Griffin, H. Venghatakrishnan, A. Zukauskas, J.-R. Wei, R. K. Dhiman, D. C. Crick, E. J. Rubin, C. M. Sassetti, T. Alber, A phosphorylated pseudokinase complex controls cell-wall synthesis in mycobacteria. Sci. Signal. 5, ra7 (2012).
9. M. Pallen, R. Chaudhuri, A. Khan, Bacterial FHA domains: Neglected players in the phosphothreonine signalling game? Trends Microbiol. 10, 556-563 (2002).
10. T. J. Nott, G. Kelly, L. Stach, J. Li, S. Westcott, D. Patel, D. M. Hunt, S. Howell, R. S. Buxton, H. M. O'Hare, S. J. Smerdon, An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis. Sci. Signal. 2, ra12 (2009).
11. D. Durocher, I. A. Taylor, D. Sarbassova, L. F. Haire, S. L. Westcott, S. P. Jackson, S. J. Smerdon, M. B. Yaffe, The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol. Cell 6, 1169-1182 (2000).
12. M. Gupta, A. Sajid, G. Arora, V. Tandon, Y. Singh, Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis. J. Biol. Chem. 284, 34723-34734 (2009).
13. M. Mir, J. Asong, X. Li, J. Cardot, G. J. Boons, R. N. Husson, The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization. PLoS Pathog. 7, e1002182 (2011).
14. V. Molle, A. K. Brown, G. S. Besra, A. J. Cozzone, L. Kremer, The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. J. Biol. Chem. 281, 30094-30103 (2006).
15. C. Roumestand, J. Leiba, N. Galophe, E. Margeat, A. Padilla, Y. Bessin, P. Barthe, V. Molle, M. Cohen-Gonsaud, Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase. Structure 19, 1525-1534 (2011).
16. M. L. Reese, G. M. Zeiner, J. P. Saeij, J. C. Boothroyd, J. P. Boyle, Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proc. Natl. Acad. Sci. U.S.A. 108, 9625-9630 (2011).
17. M. L. Reese, J. C. Boothroyd, A conserved noncanonical motif in the pseudoactive site of the ROP5 pseudokinase domain mediates its effect on Toxoplasma virulence. J. Biol. Chem. 286, 29366-29375 (2011).
18. A. Parikh, S. K. Verma, S. Khan, B. Prakash, V. K. Nandicoori, PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1- phosphate uridyltransferase, modulates its acetyltransferase activity. J. Mol. Biol. 386, 451-464 (2009).
19. V. Molle, G. Gulten, C. Vilchèze, R. Veyron-Churlet, I. Zanella-Cléon, J. C. Sacchettini, W. R. Jacobs, Jr, L. Kremer, Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Mol. Microbiol. 78, 1591-1605 (2010).
20. E. C. Hett, E. J. Rubin, Bacterial growth and cell division: A mycobacterial perspective. Microbiol. Mol. Biol. Rev. 72, 126-156 (2008).