Exaggerated inflammatory response and bony resorption from BMP-2 use in a pediatric forearm nonunion

Journal of Hand Surgery

Volumn 37, Issue 2, 2012, Pages 316-321

  Ritting, Andrew W ^a   Weber, Elizabeth W ^a   Lee, Mark C ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

BMP 2; inflammatory reaction; nonunion; pediatric forearm

Indexed keywords

CEFALEXIN; COLLAGEN SPONGE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ARTICLE; BONE RADIOGRAPHY; CASE REPORT; CHILD; DEBRIDEMENT; DISEASE COURSE; FOLLOW UP; FRACTURE NONUNION; FRACTURE REDUCTION; HUMAN; INFLAMMATION; INTRAMEDULLARY NAILING; MALE; OSSIFICATION; OSTEOLYSIS; OUTCOME ASSESSMENT; PEDIATRICS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RADIUS FRACTURE; REOPERATION; RISK BENEFIT ANALYSIS; SCHOOL CHILD; ULNA FRACTURE; WOUND DEHISCENCE;

BONE MORPHOGENETIC PROTEIN 2; BONE RESORPTION; CHILD; FRACTURES, UNUNITED; HUMANS; MALE; OFF-LABEL USE; OSTEITIS; RECOMBINANT PROTEINS; SURGICAL WOUND DEHISCENCE; TRANSFORMING GROWTH FACTOR BETA; ULNA FRACTURES;

EID: 84856276223     PISSN: 03635023     EISSN: 15316564     Source Type: Journal    
DOI: 10.1016/j.jhsa.2011.10.007     Document Type: Article

References (16)

1. M.E. Oetgen, B.S. Richards Complications associated with the use of bone morphogenetic protein in pediatric patients J Pediatr Orthop 30 2010 192 198
2. L.B. Shields, G.H. Raque, S.D. Glassman, M. Campbell, T. Vitaz, J. Harpring Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion Spine (Phila Pa 1976) 31 2006 542 547
3. K.M. MacDonald, M.M. Swanstrom, J.J. McCarthy, B.A. Nemeth, T.A. Guliani, K.J. Noonan Exaggerated inflammatory response after use of recombinant bone morphogenetic protein in recurrent unicameral bone cysts J Pediatr Orthop 30 2010 199 205
4. A.L. Jones, R.W. Bucholz, M.J. Bosse, S.K. Mirza, T.R. Lyon, L.X. Webb Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects A randomized, controlled trialk J Bone Joint Surg 88A 2006 1431 1441
5. K. Owens, S.D. Glassman, J.M. Howard, M. Djurasovic, J.L. Witten, L.Y. Carreon Perioperative complications with rhBMP-2 in transforaminal lumbar interbody fusion Eur Spine J 20 2011 612 617
6. A.R. Poynton, J.M. Lane Safety profile for the clinical use of bone morphogenetic proteins in the spine Spine (Phila Pa 1976) 27 Suppl 1 2002 S40 S48
7. V.M. Paralkar, B.S. Weeks, Y.M. Yu, H.K. Kleinman, A.H. Reddi Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen J Cell Biol 119 1992 1721 1728 (Pubitemid 23006568)
8. M.F. Termaat, F.C. Den Boer, F.C. Bakker, P. Patka, H.J. Haarman Bone morphogenetic proteins Development and clinical efficacy in the treatment of fractures and bone defects J Bone Joint Surg 87A 2005 1367 1378 (Pubitemid 40756643)
9. A. Marusic, V. Katavic, D. Grcevic, I.K. Lukic Genetic variability of new bone induction in mice Bone 25 1999 25 32 (Pubitemid 29322057)
10. A. Marusic, D. Grcevic, V. Katavic, N. Kovacic, I.K. Lukic, I. Kalajzic Role of B lymphocytes in new bone formation Lab Invest 80 2000 1761 1774
11. J.M. Toth, S.D. Boden, J.K. Burkus, J.M. Badura, S.M. Peckham, W.F. McKay Short-term osteoclastic activity induced by locally high concentrations of recombinant human bone morphogenetic protein-2 in a cancellous bone environment Spine (Phila Pa 1976) 34 2009 539 550
12. W. Hsu, J. Lieberman The role of bone graft substitutes in total hip arthroplasty J.J. Callaghan, A.G. Rosenberg, H.E. Rubash, The adult hip 2007 Lippincott, Williams & Wilkins Philadelphia 329 334
13. P. Kloen, S.B. Doty, E. Gordon, I.F. Rubel, M.J. Goumans, D.L. Helfet Expression and activation of the BMP-signaling components in human fracture nonunions J Bone Joint Surg 84A 2002 1909 1918 (Pubitemid 35283352)
14. A. Gigante, M. Cappella, S. Manzotti, S. Cecconi, F. Greco, R. Di Primio Osteoinduction properties of different growth factors on cells from non-union patients: in vitro study for clinical application J Biol Regul Homeost Agents 24 2010 51 62
15. M. Fajardo, C.J. Liu, K. Ilalov, K.A. Egol Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue J Orthop Trauma 24 2010 557 563
16. B.S. Richards, M.E. Oetgen, C.E. Johnston The use of rhBMP-2 for the treatment of congenital pseudarthrosis of the tibia: a case series J Bone Joint Surg 92A 2010 177 185