The use of rhBMP-2 for the treatment of congenital pseudarthrosis of the Tibia: A case series

Journal of Bone and Joint Surgery

Volumn 92, Issue 1, 2010, Pages 177-185

  Richards, B Stephens ^a   Oetgen, Matthew E ^a   Johnston, Charles E ^a  

^a TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN SPONGE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CHILD; CLINICAL ARTICLE; CONGENITAL PSEUDARTHROSIS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOLLOW UP; HUMAN; INTRAMEDULLARY NAILING; MALE; MEDICAL RECORD REVIEW; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; THERAPY EFFECT; TIBIA; TREATMENT DURATION; WILLIAMS INTRAMEDULLARY FIXATION; CASE REPORT; CONGENITAL MALFORMATION; INFANT; PSEUDARTHROSIS; TIBIA FRACTURE; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; BONE MORPHOGENETIC PROTEINS; CHILD; CHILD, PRESCHOOL; FEMALE; FRACTURE FIXATION, INTRAMEDULLARY; HUMANS; INFANT; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PSEUDARTHROSIS; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; TIBIA; TIBIAL FRACTURES; TRANSFORMING GROWTH FACTOR BETA;

EID: 73949122033     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.H.01667     Document Type: Article

References (22)

1. Grill F, Bollini G, Dungl P, Fixsen J, Hefti F, Ippolito E, Romanus B, Tudisco C, Wientroub S. Treatment approaches for congenital pseudarthrosis of tibia: results of the EPOS multicenter study. European Paediatric Orthopaedic Society (EPOS). J Pediatr Orthop B. 2000;9:75-89.
2. Lehman WB, Atar D, Feldman DS, Gordon JC, Grant AD. Congenital pseudoarthrosis of the tibia. J Pediatr Orthop B. 2000;9:103-7.
3. Tudisco C, Bollini G, Dungl P, Fixen J, Grill F, Hefti F, Romanus B, Wientroub S. Functional results at the end of skeletal growth in 30 patients affected by congenital pseudoarthrosis of the tibia. J Pediatr Orthop B. 2000;9:94-102. (Pubitemid 30253774)
4. Dobbs MB, Rich MM, Gordon JE, Szymanski DA, Schoenecker PL. Use of an intramedullary rod for treatment of congenital pseudarthrosis of the tibia. A long-term follow-up study. J Bone Joint Surg Am. 2004;86:1186-97.
5. Johnston CE 2nd. Congenital pseudarthrosis of the tibia: results of technical variations in the Charnley-Williams procedure. J Bone Joint Surg Am. 2002;84:1799-810.
6. Romanus B, Bollini G, Dungl P, Fixsen J, Grill F, Hefti F, Ippolito E, Tudisco C, Wientroub S. Free vascular fibular transfer in congenital pseudoarthrosis of the tibia: results of the EPOS multicenter study. European Paediatric Orthopaedic Society (EPOS). J Pediatr Orthop B. 2000;9:90-3.
7. Uchida Y, Kojima T, Sugioka Y. Vascularised fibular graft for congenital pseudarthrosis of the tibia. Long-term results. J Bone Joint Surg Br. 1991;73:846-50.
8. Ohnishi I, Sato W, Matsuyama J, Yajima H, Haga N, Kamegaya M, Minami A, Sato M, Yoshino S, Oki T, Nakamura K. Treatment of congenital pseudarthrosis of the tibia: a multicenter study in Japan. J Pediatr Orthop. 2005;25:219-24.
9. Paley D, Catagni M, Argnani F, Prevot J, Bell D, Armstrong P. Treatment of congenital pseudoarthrosis of the tibia using the Ilizarov technique. Clin Orthop Relat Res. 1992;280:81-93.
10. Termaat MF, Den Boer FC, Bakker FC, Patka P, Haarman HJ. Bone morphogenetic proteins. Development and clinical efficacy in the treatment of fractures and bone defects. J Bone Joint Surg Am. 2005;87:1367-78. (Pubitemid 40756643)
11. Kwong FN, Harris MB. Recent developments in the biology of fracture repair. J Am Acad Orthop Surg. 2008;16:619-25.
12. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am. 2001;83 Suppl 1(Pt 2):S151-8.
13. Geesink RG, Hoefnagels NH, Bulstra SK. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J Bone Joint Surg Br. 1999;81:710-8.
14. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, Aro H, Atar D, Bishay M, Börner MG, Chiron P, Choong P, Cinats J, Courtenay B, Feibel R, Geulette B, Gravel C, Haas N, Raschke M, Hammacher E, van der Velde D, Hardy P, Holt M, Josten C, Ketterl RL, Lindeque B, Lob G, Mathevon H, McCoy G, Marsh D, Miller R, Munting E, Oevre S, Nordsletten L, Patel A, Pohl A, Rennie W, Reynders P, Rommens PM, Rondia J, Rossouw WC, Daneel PJ, Ruff S, Rüter A, Santavirta S, Schildhauer TA, Gekle C, Schnettler R, Segal D, Seiler H, Snowdowne RB, Stapert J, Taglang G, Verdonk R, Vogels L, Weckbach A, Wentzensen A, Wisniewski T; BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002;84:2123-34.
15. Inan M, El Rassi G, Riddle EC, Kumar SJ. Residual deformities following successful initial bone union in congenital pseudoarthrosis of the tibia. J Pediatr Orthop. 2006;26:393-9.
16. Burkus JK, Transfeldt EE, Kitchel SH, Watkins RG, Balderston RA. Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine (Phila Pa 1976). 2002;27:2396-408.
17. Lee FY, Sinicropi SM, Lee FS, Vitale MG, Roye DP Jr, Choi IH. Treatment of congenital pseudarthrosis of the tibia with recombinant human bone morphogenetic protein-7 (rhBMP-7). A report of five cases. J Bone Joint Surg Am. 2006;88:627-33.
18. Anticevic D, Jelic M, Vukicevic S. Treatment of a congenital pseudarthrosis of the tibia by osteogenic protein-1 (bone morphogenetic protein-7): a case report. J Pediatr Orthop B. 2006;15:220-1.
19. Fabeck L, Ghafil D, Gerroudj M, Baillon R, Delincé P. Bone morphogenetic protein 7 in the treatment of congenital pseudarthrosis of the tibia. J Bone Joint Surg Br. 2006;88:116-8.
20. Kujala S, Vähäsarja V, Serlo W, Jalovaara P. Treatment of congenital pseudarthrosis of the tibia with native bovine BMP: a case report. Acta Orthop Belg. 2008;74:132-6.
21. Carreon LY, Glassman SD, Brock DC, Dimar JR, Puno RM, Campbell MJ. Adverse events in patients re-exposed to bone morphogenetic protein for spine surgery. Spine (Phila Pa 1976). 2008;33:391-3.
22. Harwood PJ, Giannoudis PV. Application of bone morphogenetic proteins in orthopaedic practice: their efficacy and side effects. Expert Opin Drug Saf. 2005;4:75-89.