Application of electron conformational-genetic algorithm approach to 1,4-dihydropyridines as calcium channel antagonists: Pharmacophore identification and bioactivity prediction

Journal of Molecular Modeling

Volumn 18, Issue 1, 2012, Pages 65-82

  Geçen, Nazmiye ^a   SarIpInar, Emin ^b   Yanmaz, Ersin ^c   Şahin, Kader ^d  

^a SIIRT UNIVERSITY   (Turkey)

^b ERCIYES UNIVERSITY   (Turkey)

^c BALIKESIR UNIVERSITY   (Turkey)

^d BITLIS EREN UNIVERSITY   (Turkey)

Author keywords

4D QSAR; Dihydropyridines; Drug design; Electron conformational genetic algorithm; Pharmacophore

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT;

ANALYTIC METHOD; ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; ELECTRON CONFORMATIONAL GENETIC ALGORITHM METHOD; GENETIC ALGORITHM; MOLECULAR INTERACTION; PARAMETERS; PHARMACOPHORE; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ALGORITHMS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DIHYDROPYRIDINES; DRUG DESIGN; ELECTRONS; MODELS, CHEMICAL; MODELS, THEORETICAL; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, DRUG;

EID: 84856275323     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-011-1024-5     Document Type: Article

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