Thromboprophylaxis, bleeding and post-operative prosthetic joint infection in total hip and knee arthroplasty: A comprehensive literature review

Expert Opinion on Pharmacotherapy

Volumn 13, Issue 3, 2012, Pages 333-344

  Kwong, Louis M ^a   Kistler, Kristin D ^b   Mills, Roger ^c   Wildgoose, Peter ^c   Klaskala, Winslow ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ProSanos Corporation   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Bleeding; Hip arthroplasty; Knee arthroplasty; Retrospective database study; Thromboprophylaxis; Venous thromboembolism

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; APIXABAN; ARGATROBAN; AZD 0837; BEMIPARIN; BETRIXABAN; CLOPIDOGREL; DAREXABAN; EDOXABAN; ENOXAPARIN; ERIBAXABAN; FONDAPARINUX; HEPARIN; LEPIRUDIN; LETAXABAN; LOW MOLECULAR WEIGHT HEPARIN; MELAGATRAN; N [2 [4 (1 METHYL 4 PIPERIDINYL) 1 PIPERAZINYL] 2 OXO 1 PHENYLETHYL] 1H INDOLE 6 CARBOXAMIDE; RIVAROXABAN; UNCLASSIFIED DRUG; WARFARIN; XIMELAGATRAN;

HUMAN; INFECTION RISK; INFECTIOUS ARTHRITIS; INTERNATIONAL NORMALIZED RATIO; PATHOPHYSIOLOGY; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE INFECTION; PROSTHESIS INFECTION; REVIEW; RISK FACTOR; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT; VENOUS THROMBOEMBOLISM; WOUND INFECTION;

ANTICOAGULANTS; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; EVIDENCE-BASED MEDICINE; HIP PROSTHESIS; HUMANS; KNEE PROSTHESIS; POSTOPERATIVE HEMORRHAGE; PROSTHESIS-RELATED INFECTIONS; RISK ASSESSMENT; RISK FACTORS; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM;

EID: 84856261047     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2012.652087     Document Type: Review

References (64)

1. National Institutes of Health (NIH) Consensus Development Panel on Total Knee Replacement. National Institutes of Health consensus statement on total knee replacement. U.S. Department of Health and Human Services (DHHS); Washington, DC: 2003
2. Ng CY, Ballantyne JA, Brenkel IJ. Quality of life and functional outcome after primary total hip replacement. A five-year follow-up. J Bone Joint Surg Br 2007;89:868-73 (Pubitemid 47322782)
3. Bozic KJ, Kurtz SM, Lau E, et al. The epidemiology of revision total hip arthroplasty in the United States. J Bone Joint Surg Am 2009;91:128-33
4. Bozic KJ, Katz P, Cisternas M, et al. Hospital resource utilization for primary and revision total hip arthroplasty. J Bone Joint Surg Am 2005;87:570-6 (Pubitemid 40315008)
5. Ong KL, Mowat FS, Chan N, et al. Economic burden of revision hip and knee arthroplasty in medicare enrollees. Clin Orthop Relat Res 2006;446:22-8 (Pubitemid 44318258)
6. Kurtz SM, Ong K, Lau E, et al. Prosthetic joint infection risk following total hip and knee arthroplasty in the medicare population. J Arthroplasty 2009;24:e4
7. Kurtz S, Mowat F, Ong K, et al. Prevalence of primary and revision total hip and knee arthroplasty in the United States from 1990 through 2002. J Bone Joint Surg Am 2005;87:1487-97 (Pubitemid 40917748)
8. Kurtz S, Ong K, Lau E, et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 2007;89:780-5 (Pubitemid 46564282)
9. Crowther MA, Warkentin TE. Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents. Blood 2008;111:4871-9
10. Levine MN, Raskob G, Beyth RJ, et al. Hemorrhagic complications of anticoagulant treatment: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 2004;126:287S-310S (Pubitemid 39297958)
11. Lieberman JR, Hsu WK. Prevention of venous thromboembolic disease after total hip and knee arthroplasty. J Bone Joint Surg Am 2005;87:2097-112 (Pubitemid 41279143)
12. American Academy of Orthopaedic Surgeons Clinical Guideline on Prevention of Symptomatic Pulmonary Embolism in Patients Undergoing Total Hip or Knee Arthroplasty. American Academy of Orthopaedic Surgeons; Rosemont, IL: 2007
13. Parvizi J, Ghanem E, Joshi A, et al. Does "excessive" anticoagulation predispose to periprosthetic infection? J Arthroplasty 2007;22:24-8 (Pubitemid 47332999)
14. Saleh K, Olson M, Resig S, et al. Predictors of wound infection in hip and knee joint replacement: results from a 20 year surveillance program. J Orthop Res 2002;20:506-15 (Pubitemid 34464075)
15. Patel VP, Walsh M, Sehgal B, et al. Factors associated with prolonged wound drainage after primary total hip and knee arthroplasty. J Bone Joint Surg Am 2007;89:33-8 (Pubitemid 46059142)
16. Asensio A, Ramos A, Munez E, et al. Preoperative low molecular weight heparin as venous thromboembolism prophylaxis in patients at risk for prosthetic infection after knee arthroplasty. Infect Control Hosp Epidemiol 2005;26:903-9 (Pubitemid 43088871)
17. Pulido L, Ghanem E, Joshi A, et al. Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clin Orthop Relat Res 2008;466:1710-15
18. Jamsen E, Huhtala H, Puolakka T, Moilanen T. Risk factors for infection after knee arthroplasty. A register-based analysis of 43,149 cases. J Bone Joint Surg Am 2009;91:38-47
19. Galat DD, McGovern SC, Larson DR, et al. Surgical treatment of early wound complications following primary total knee arthroplasty. J Bone Joint Surg Am 2009;91:48-54
20. Galat DD, McGovern SC, Hanssen AD, et al. Early return to surgery for evacuation of a postoperative hematoma after primary total knee arthroplasty. J Bone Joint Surg Am 2008;90:2331-6
21. Choong PF, Dowsey MM, Carr D, et al. Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampin-based regimen. Acta Orthop 2007;78:755-65 (Pubitemid 351185596)
22. Minnema B, Vearncombe M, Augustin A, et al. Risk factors for surgical-site infection following primary total knee arthroplasty. Infect Control Hosp Epidemiol 2004;25:477-80 (Pubitemid 38758492)
23. Sanchez-Ballester J, Smith M, Hassan K, et al. Wound infection in the management of hip fractures: a comparison between low-molecular weight heparin and mechanical prophylaxis. Acta Orthop Belg 2005;71:55-9 (Pubitemid 40349324)
24. Dowsey MM, Choong PF. Obesity is a major risk factor for prosthetic infection after primary hip arthroplasty. Clin Orthop Relat Res 2008;466:153-8 (Pubitemid 351903851)
25. Innerhofer P, Klingler A, Klimmer C, et al. Risk for postoperative infection after transfusion of white blood cell-filtered allogeneic or autologous blood components in orthopedic patients undergoing primary arthroplasty. Transfusion 2005;45:103-10
26. Bongartz T, Halligan CS, Osmon DR, et al. Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. Arthritis Rheum 2008;59:1713-20
27. Peersman G, Laskin R, Davis J, et al. ASA physical status classification is not a good predictor of infection for total knee replacement and is influenced by the presence of comorbidities. Acta Orthop Belg 2008;74:360-4
28. Ridgeway S, Wilson J, Charlet A, et al. Infection of the surgical site after arthroplasty of the hip. J Bone Joint Surg Br 2005;87:844-50 (Pubitemid 40862073)
29. Kourbatova EV, Halvosa JS, King MD, et al. Emergence of community-associated methicillin-resistant Staphylococcus aureus USA 300 clone as a cause of health care-associated infections among patients with prosthetic joint infections. Am J Infect Control 2005;33:385-91 (Pubitemid 41253663)
30. Smabrekke A, Espehaug B, Havelin LI, Furnes O. Operating time and survival of primary total hip replacements: an analysis of 31,745 primary cemented and uncemented total hip replacements from local hospitals reported to the Norwegian Arthroplasty Register 1987-2001. Acta Orthop Scand 2004;75:524-32 (Pubitemid 39425274)
31. Brandt C, Hansen S, Sohr D, et al. Finding a method for optimizing risk adjustment when comparing surgical-site infection rates. Infect Control Hosp Epidemiol 2004;25:313-18 (Pubitemid 38524908)
32. van Kasteren ME, Mannien J, Ott A, et al. Antibiotic prophylaxis and the risk of surgical site infections following total hip arthroplasty: timely administration is the most important factor. Clin Infect Dis 2007;44:921-7 (Pubitemid 46452055)
33. Huotari K, Lyytikainen O, Seitsalo S. Patient outcomes after simultaneous bilateral total hip and knee joint replacements. J Hosp Infect 2007;65:219-25
34. Babkin Y, Raveh D, Lifschitz M, et al. Incidence and risk factors for surgical infection after total knee replacement. Scand J Infect Dis 2007;39:890-5 (Pubitemid 47470779)
35. Cumming D, Parker MJ. Urinary catheterisation and deep wound infection after hip fracture surgery. Int Orthop 2007;31:483-5 (Pubitemid 47101377)
36. Engesaeter LB, Espehaug B, Lie SA, et al. Does cement increase the risk of infection in primary total hip arthroplasty? Revision rates in 56,275 cemented and uncemented primary THAs followed for 0-16 years in the Norwegian Arthroplasty Register. Acta Orthop 2006;77:351-8 (Pubitemid 43977388)
37. Dowsey MM, Choong PF. Obese diabetic patients are at substantial risk for deep infection after primary TKA. Clin Orthop Relat Res 2009;467:1577-81
38. Ritter MA, Olberding EM, Malinzak RA. Ultraviolet lighting during orthopaedic surgery and the rate of infection. J Bone Joint Surg Am 2007;89:1935-40 (Pubitemid 350195023)
39. SooHoo NF, Zingmond DS, Lieberman JR, Ko CY. Primary total knee arthroplasty in California 1991 to 2001: does hospital volume affect outcomes? J Arthroplasty 2006;21:199-205 (Pubitemid 43339873)
40. Geubbels EL, Grobbee DE, Vandenbroucke-Grauls CM, et al. Improved risk adjustment for comparison of surgical site infection rates. Infect Control Hosp Epidemiol 2006;27:1330-9 (Pubitemid 46052280)
41. Browne JA, Pietrobon R, Olson SA. Hip fracture outcomes: does surgeon or hospital volume really matter? J Trauma 2009;66:809-14
42. Katz JN, Barrett J, Mahomed NN, et al. Association between hospital and surgeon procedure volume and the outcomes of total knee replacement. J Bone Joint Surg Am 2004;86-A:1909-16 (Pubitemid 39223458)
43. Kurtz SM, Lau E, Schmier J, et al. Infection burden for hip and knee arthroplasty in the United States. J Arthroplasty 2008;23:984-91
44. Chesney D, Sales J, Elton R, Brenkel IJ. Infection after knee arthroplasty a prospective study of 1509 cases. J Arthroplasty 2008;23:355-9 (Pubitemid 351389336)
45. Thomas C, Cadwallader HL, Riley TV. Surgical-site infections after orthopaedic surgery: statewide surveillance using linked administrative databases. J Hosp Infect 2004;57:25-30 (Pubitemid 38594517)
46. Ibrahim SA, Stone RA, Han X, et al. Racial/ethnic differences in surgical outcomes in veterans following knee or hip arthroplasty. Arthritis Rheum 2005;52:3143-51 (Pubitemid 41447096)
47. Muilwijk J, Walenkamp GH, Voss A, et al. Random effect modelling of patient-related risk factors in orthopaedic procedures: results from the Dutch nosocomial infection surveillance network 'PREZIES'. J Hosp Infect 2006;62:319-26 (Pubitemid 43192323)
48. Lee J, Singletary R, Schmader K, et al. Surgical site infection in the elderly following orthopaedic surgery. Risk factors and outcomes. J Bone Joint Surg Am 2006;88:1705-12 (Pubitemid 44200207)
49. Lai K, Bohm ER, Burnell C, Hedden DR. Presence of medical comorbidities in patients with infected primary hip or knee arthroplasties. J Arthroplasty 2007;22:651-6 (Pubitemid 47198430)
50. Namba RS, Paxton L, Fithian DC, Stone ML. Obesity and perioperative morbidity in total hip and total knee arthroplasty patients. J Arthroplasty 2005;20:46-50 (Pubitemid 41425785)
51. Lubbeke A, Moons KG, Garavaglia G, Hoffmeyer P. Outcomes of obese and nonobese patients undergoing revision total hip arthroplasty. Arthritis Rheum 2008;59:738-45 (Pubitemid 351679551)
52. Lubbeke A, Stern R, Garavaglia G, et al. Differences in outcomes of obese women and men undergoing primary total hip arthroplasty. Arthritis Rheum 2007;57:327-34 (Pubitemid 47164097)
53. Grant JA, Viens N, Bolognesi MP, et al. Two-year outcomes in primary THA in obese male veterans administration medical center patients. Rheumatol Int 2008;28:1105-9
54. Moon HK, Han CD, Yang IH, Cha BS. Factors affecting outcome after total knee arthroplasty in patients with diabetes mellitus. Yonsei Med J 2008;49:129-37 (Pubitemid 351513655)
55. Myers E, O'Grady P, Dolan AM. The influence of preclinical anaemia on outcome following total hip replacement. Arch Orthop Trauma Surg 2004;124:699-701 (Pubitemid 40057895)
56. Thromboembolic Risk Factors (THRIFT) Consensus Group. Risk of and prophylaxis for venous thromboembolism in hospital patients. BMJ 1992;305:567-74
57. Novicoff WM, Brown TE, Cui Q, et al. Mandated venous thromboembolism prophylaxis: possible adverse outcomes. J Arthroplasty 2008;23:15-19
58. Camporese G, Bernardi E, Prandoni P, et al. Low-molecular-weight heparin versus compression stockings for thromboprophylaxis after knee arthroscopy: a randomized trial. Ann Intern Med 2008;149:73-82 (Pubitemid 352008595)
59. Levine MN, Gent M, Hirsh J, et al. Ardeparin (low-molecular-weight heparin) vs graduated compression stockings for the prevention of venous thromboembolism. A randomized trial in patients undergoing knee surgery. Arch Intern Med 1996;156:851-6 (Pubitemid 26119812)
60. Boyd HS. VTE prevention in major orthopedic surgery. Cleve Clin J Med 2008;75:471-2
61. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133:381S-453S (Pubitemid 351894916)
62. Johanson NA, Lachiewicz PF, Lieberman JR, et al. Prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. J Am Acad Orthop Surg 2009;17:183-96
63. Robins J. The control of confounding by intermediate variables. Stat Med 1989;8:679-701 (Pubitemid 19179868)
64. Robins JM, Greenland S. Identifiability and exchangeability for direct and indirect effects. Epidemiology 1992;3:143-55