Solution-state NMR spectroscopy of famotidine revisited: Spectral assignment, protonation sites, and their structural consequences

Analytical and Bioanalytical Chemistry

Volumn 402, Issue 4, 2012, Pages 1653-1666

  Marosi, Attila ^a   Szalay, Zsófia ^b   Béni, Szabolcs ^a   Szakács, Zoltán ^b   Gáti, Tamás ^b   Rácz, Ákos ^a   Noszál, Béla ^a   Demeter, Ádám ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b GEDEON RICHTER LTD   (Hungary)

Author keywords

Conformation; Famotidine; Famotidone; NMR assignment; NMR titration; pK a

Indexed keywords

FAMOTIDINE; FAMOTIDONE; NMR ASSIGNMENT; NMR TITRATION; PK A;

ALKALINITY; CALCULATIONS; COMPLEXATION; CONFORMATIONS; DIMETHYL SULFOXIDE; EXPERIMENTS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC SOLVENTS; PH; PROTONATION; QUANTUM CHEMISTRY; TITRATION;

HYDROGEN BONDS;

DIMETHYL SULFOXIDE; FAMOTIDINE; HISTAMINE H2 RECEPTOR ANTAGONIST; PROTON; WATER;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

DIMETHYL SULFOXIDE; FAMOTIDINE; HISTAMINE H2 ANTAGONISTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTONS; WATER;

EID: 84856233021     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5599-6     Document Type: Article

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