Electrodeless, accurate pH determination in highly basic media using a new set of 1H NMR pH indicators

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 5, 2011, Pages 958-964

  Orgován, Gábor ^a   Noszál, Béla ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Electrodeless pH determination; Highly basic media; Metformin; NMR pH indicator; Protonation constant

Indexed keywords

BIGUANIDE DERIVATIVE; METFORMIN; PHENFORMIN;

ANALYTICAL PARAMETERS; ARTICLE; ELECTRODE; PH MEASUREMENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT;

HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; METFORMIN; MOLECULAR STRUCTURE; OSMOLAR CONCENTRATION; PHARMACEUTICAL PREPARATIONS; PHENFORMIN; POTENTIOMETRY; PROTONS; REPRODUCIBILITY OF RESULTS; SOLUTIONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 78751702015     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.11.022     Document Type: Article

References (24)

1. Popov K., Rönkkömäki H., Lajunen L.H.J. Guidelines for NMR measurements for determination of high and low pKa values: (IUPAC technical report). Pure Appl. Chem. 2006, 78:663-675.
2. Buck R.P., Rondinini S., Covington A.K., Baucke F.G.K., Brett C.M.A., Camões M.F., Milton M.J.T., Mussini T., Naumann R., Pratt K.W., Spitzer P., Wilson G.S. Measurement of pH. Definition, standards, and procedures (IUPAC Recommendations 2002). Pure Appl. Chem. 2002, 74:2169-2200.
3. Gans P., O'Sullivan B. GLEE, a new computer program for glass electrode calibration. Talanta 2000, 51:33-37.
4. Avdeef A, Bucher J.J. Accurate measurements of the concentration of hydrogen ions with a glass electrode: calibrations using the Prideaux and other universal buffer solutions and a computer-controlled automatic titrator. Anal. Chem. 1978, 50:2137-2142.
5. Sigel H., Zuberbühler A.D., Yamauchi O. Comments on potentiometric pH titrations and the relationship between pH-meter reading and hydrogen ion concentration. Anal. Chim. Acta 1991, 255:63-72.
6. Safavi A., Abdollahi H. Optical sensor for high pH values. Anal. Chim. Acta 1998, 367:167-173.
7. Szakács Z., Hägele G., Tyka R. 1H/31P NMR pH indicator series to eliminate the glass electrode in NMR spectroscopic pKa determinations. Anal. Chim. Acta 2004, 522:247-258.
8. Tynkkynen T., Tiainen M., Soininen P., Laatikainen R. From proton nuclear magnetic resonance spectra to pH. Assessment of 1H NMR pH indicator compound set for deuterium oxide solutions. Anal. Chim. Acta 2009, 648:105-112.
9. Baryshnikova O., Williams T., Sykes B. Internal pH indicators for biomolecular NMR. J. Biomol. NMR 2008, 41:5-7.
10. Gutowsky H.S., Saika A. Dissociation, chemical exchange, and the proton magnetic resonance in some aqueous electrolytes. J. Chem. Phys. 1953, 21:1688-1694.
11. Grunwald E., Loewenstein A., Meiboom S. Application of nuclear magnetic resonance to the study of acid-base equilibria. J. Chem. Phys. 1957, 27:641-642.
12. STAN Sirius Technical Application Notes 1994, vol.1. Sirius Anal. Instr. Ltd., Forest Row.
13. STAN Sirius Technical Application Notes 1995, vol. 2. Sirius Anal. Instr. Ltd., Forest Row.
14. Perrin C.L., Fabian M.A. Multicomponent NMR titration for simultaneous measurement of relative pKas. Anal. Chem. 1996, 68:2127-2134.
15. Dissociation constants of organic acids and bases. CRC Handbook of Chemistry and Physics 2009, CRC Press/Taylor and Francis, Boca Raton, FL, pp. 8-42-8-51. R.D. Lide (Ed.).
16. Boros M., Kökösi J., Vámos J., Noszál B. Complete resolution of the microscopic protonation equilibria of N-methyl-d-aspartic acid and related compounds. J. Pharm. Biomed. Anal. 2007, 43:1306-1314.
17. Glasoe P.K., Long F.A. Use of glass electrodes to measure acidities in deuterium oxide. J. Phys. Chem. 1960, 64:188-190.
18. Purlee E.L. On the solvent isotope effect of deuterium in aqueous acid solutions. J. Am. Chem. Soc. 1959, 81:263-272.
19. Hwang T.L., Shaka A.J. Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients. J. Magn. Reson. A 1995, 112:275-279.
20. OriginPro 8.1, Originlab. http://www.originlab.com/.
21. Topping J. Errors of Observation and Their Treatment 1972, Chapman and Hall, London.
22. Frassineti C., Ghelli S., Gans P., Sabatini A., Moruzzi M.S., Vacca A. Nuclear magnetic resonance as a tool for determining protonation constants of natural polyprotic bases in solution. Anal. Biochem. 1995, 231:374-382.
23. Krentz A.J., Bailey C.J. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 2005, 65:385-411.
24. Orgován G., Noszál B. The complete microspeciation of arginine and citrulline. J. Pharm. Biomed. Anal. 2011, 54:965-971.