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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 3, 2012, Pages 1397-1401

Design and synthesis of boronic acid inhibitors of endothelial lipase

(6) O'Connell, Daniel P a Leblanc, Daniel F a Cromley, Debra b Billheimer, Jeffrey b Rader, Daniel J b Bachovchin, William W a

a TUFTS UNIVERSITY SCHOOL OF MEDICINE (United States)

b UNIVERSITY OF PENNSYLVANIA (United States)

Author keywords

Boronic acids; Endothelial lipase; HDL cholesterol; Lipoprotein lipase; Small molecule inhibitors

Indexed keywords

3 PENTYLPHENYLBORONIC ACID; 4 PENTYLPHENYLBORONIC ACID; BENZENEBORONIC ACID; BORONIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN LIPASE; PHOSPHOLIPASE INHIBITOR; PINACOL(2 NONYLPHENYL)BORONATE; PINACOL(4 PHENYLPHENYL)BORONATE; PINACOL(PHENYLBORONATE)ESTER DERIVATIVE; PINACOL[4 (4 FLUOROPHENYL)PHENYL]BORONATE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; ATHEROGENESIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENZYME INHIBITION; REGULATORY MECHANISM;

BORONIC ACIDS; DRUG DESIGN; ENDOTHELIUM; ENZYME ACTIVATION; INHIBITORY CONCENTRATION 50; LIPASE; MOLECULAR STRUCTURE; PALMITIC ACID;

EID: 84856230163 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.12.043 Document Type: Article

Times cited : (24)

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