Identification of important structural features of thiazolo[4,5-d] pyrimidines required for potent antifungal activity

Medicinal Chemistry Research

Volumn 20, Issue 9, 2011, Pages 1450-1454

  Chhabria, Mahesh ^a   Rathod, Ishwarsinh ^a   Vala, Khushbu ^a   Patel, Paulomi ^a  

^a GUJARAT UNIVERSITY   (India)

Author keywords

Antifungal; MIC; Thiazolo 4,5 d pyrimidine

Indexed keywords

3 (2 METHOXYPHENYL) 5 [(2,6 DIMETHYLPHENYL)AMINO 6 (2,6 DIMETHYLPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H) HIONE; 3 (2 METHOXYPHENYL) 5 [(4 METHOXYPHENYL)AMINO 6 (4 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (3 CHLORO 4 FLUOROPHENYL) 5 [(4 BROMOPHENYL)AMINO 6 (4 BROMOPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (3 CHLORO 4 FLUOROPHENYL) 5 [(4 METHOXYPHENYL)AMINO 6 (4 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (3,4 DICHLOROPHENYL) 5 [(4 BROMOPHENYL)AMINO 6 (4 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (3,4 DICHLOROPHENYL) 5 [(4 METHOXYPHENYL)AMINO 6 (4 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (4 BROMOPHENYL) 5 [(4 METHOXYPHENYL)AMINO 6 (4 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (4 METHOXYPHENYL) 5 [(2 METHOXYPHENYL)AMINO 6 (2 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (4 METHOXYPHENYL) 5 [(4 BROMOPHENYL)AMINO 6 (4 BROMOPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (4 METHOXYPHENYL) 5 [(4 FLUOROPHENYL)AMINO 6 (4 FLUOROPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (4 METHOXYPHENYL) 5 [(4 METHOXYPHENYL)AMINO 6 (4 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (ETHYL) 5 [(4 METHOXYPHENYL)AMINO 6 (4 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (PHENYL) 5 ([2 METHYLPHENYL)AMINO 6 (2 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (PHENYL) 5 [(2,6 DIMETHYLPHENYL)AMINO 6 (4 DIMETHYLPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (PHENYL) 5 [(4 METHOXYPHENYL)AMINO 6 (4 METHOXYPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (PHENYL) 5 [(4 METHYLPHENYL)AMINO 6 (4 METHYLPHENYL)]THIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; 3 (PHENYL) 5 PHENYLAMINO 6 PHENYLTHIAZOLO[4,5 D]PYRIMIDINE 7 (6H)ONE 2 (3H)THIONE; ANTIFUNGAL AGENT; FLUCONAZOLE; NYSTATIN; PYRIMIDINE DERIVATIVE; THIENO[4,5 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ASPERGILLUS; ASPERGILLUS NIGER; CANDIDA ALBICANS; CHEMICAL STRUCTURE; CONFERENCE PAPER; FUNGAL STRAIN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

EID: 84856229740     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9378-2     Document Type: Conference Paper

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