Effect of surgical repair on testosterone production in infertile men with varicocele: A meta-analysis

International Journal of Urology

Volumn 19, Issue 2, 2012, Pages 149-154

  Li, Fuping ^a,b   Yue, Huanxun ^b   Yamaguchi, Kohei ^a   Okada, Keisuke ^a   Matsushita, Kei ^a   Ando, Makoto ^a   Chiba, Koji ^a   Fujisawa, Masato ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Leydig cell; Meta analysis; Testosterone; Varicocele; Varicocelectomy

Indexed keywords

TESTOSTERONE;

ARTICLE; CELL FUNCTION; FOLLOW UP; HORMONE SYNTHESIS; HUMAN; LEYDIG CELL; MALE INFERTILITY; MEASUREMENT; MEDLINE; META ANALYSIS; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; SCLEROTHERAPY; SYSTEMATIC REVIEW; TESTOSTERONE BLOOD LEVEL; VARICOCELE; VARICOCELECTOMY;

HUMANS; INFERTILITY, MALE; MALE; RISK FACTORS; TESTOSTERONE; UROLOGIC SURGICAL PROCEDURES, MALE; VARICOCELE;

EID: 84856219736     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2011.02890.x     Document Type: Article

References (32)

1. World Health Organization. The influence of varicocele on parameters of fertility in a large group of men presenting in infertility clinics. Fertil. Steril. 1992; 57: 1289-93.
2. Gorelick JI, Goldstein M. Loss of fertility in men with varicocele. Fertil. Steril. 1993; 59: 613-16.
3. Jarow JP, Coburn M, Sigman M. Incidence of varicoceles in men with primary and secondary infertility. Urology 1996; 47: 73-6.
4. Marmar JL, Agarwal A, Prabakaran S etal. Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis. Fertil. Steril. 2007; 88: 639-48.
5. Jarow JP. Effects of varicocele on male fertility. Hum. Reprod. Update 2001; 7: 59-64.
6. Luo DY, Yang G, Liu JJ, Yang YR, Dong Q. Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells. Asian J. Androl. 2011; 13: 287-91.
7. Cayan S, Kadioglu A, Orhan I, Kandirali E, Tefekli A, Tellaloglu S. The effect of microsurgical varicocelectomy on serum follicle stimulating hormone, testosterone and free testosterone levels in infertile men with varicocele. BJU Int. 1999; 84: 1046-9.
8. Andò S, Giacchetto C, Colpi G etal. Physiopathologic aspects of Leydig cell function in varicocele patients. J. Androl. 1984; 5: 163-70.
9. Tanrikut C, Goldstein M. Varicocele repair for treatment of androgen deficiency. Curr. Opin. Urol. 2010; 20: 500-2.
10. Zwahlen M, Renehan A, Egger M. Meta-analysis in medical research: potentials and limitations. Urol. Oncol. 2008; 26: 320-9.
11. Stroup DF, Berlin JA, Morton SC etal. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-12.
12. Agarwal A, Deepinder F, Cocuzza M etal. Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach. Urology 2007; 70: 532-8.
13. Häuser W, Bernardy K, Uçeyler N. Treatment of fibromyalgia syndrome with antidepressants: a meta-analysis. JAMA 2009; 301: 198-209.
14. Ozden C, Ozdal OL, Bulut S, Guzel O, Koyuncu HH, Memis A. Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele. Scand. J. Urol. Nephrol. 2008; 42: 441-3.
15. Sirvent JJ, Bernat R, Navarro MA, Rodriguez Tolra J, Guspi R, Bosch R. Leydig cell in idiopathic varicocele. Eur. Urol. 1990; 17: 257-61.
16. Tanrikut C, Goldstein M, Rosoff JS, Lee RK, Nelson CJ, Mulhall JP. Varicocele as a risk factor for androgen deficiency and effect of repair. BJU Int. 2011; 108: 1480-4.
17. Tanrikut C, Choi JM, Lee RK. Varicocele is a risk factor for androgen deficiency. Fertil. Steril. 2007; 88 (Supp 1): S386.
18. Hurtado de Catalfo GE, Ranieri-Casilla A, Marra FA, de Alaniz MJ, Marra CA. Oxidative stress biomarkers and hormonal profile in human patients undergoing varicocelectomy. Int. J. Androl. 2007; 30: 519-30.
19. Su LM, Goldstein M, Schlegel PN. The effect of varicocelectomy on serum testosterone levels in infertile men with varicoceles. J. Urol. 1995; 154: 1752-5.
20. Rodriguez Peña M, Alescio L, Russell A, Lourenco da Cunha J, Alzu G, Bardoneschi E. Predictors of improved seminal parameters and fertility after varicocele repair in young adults. Andrologia 2009; 41: 277-81.
21. Lee RK, Li PS, Goldstein M. Simultaneous vasectomy and varicocelectomy: indications and technique. Urology 2007; 70: 362-5.
22. Fujisawa M, Dobashi M, Yamasaki T etal. Significance of serum inhibin B concentration for evaluating improvement in spermatogenesis after varicocelectomy. Hum. Reprod. 2001; 16: 1945-9.
23. Pierik FH, Abdesselam SA, Vreeburg JT, Dohle GR, De Jong FH, Weber RF. Increased serum inhibin B levels after varicocele treatment. Clin. Endocrinol. (Oxf.) 2001; 54: 775-80.
24. Di Bisceglie C, Bertagna A, Baldi M etal. Varicocele sclerotherapy improves serum inhibin B levels and seminal parameters. Int. J. Androl. 2007; 30: 531-6.
25. Hsiao W, Rosoff JS, Pale JR, Greenwood EA, Goldstein M. Older age is associated with similar improvements in semen parameters and testosterone after subinguinal microsurgical varicocelectomy. J. Urol. 2011; 185: 620-5.
26. Reşorlu B, Kara C, Sahin E, Unsal A. The significance of age on success of surgery for patients with varicocele. Int. Urol. Nephrol. 2010; 42: 351-6.
27. Goldstein M, Eid JF. Elevation of intratesticular and scrotal skin surface temperature in men with varicocele. J. Urol. 1989; 142: 743-5.
28. Ando S, Giacchetto C, Colpi G. Plasma levels of 17-OH-progesterone and testosterone in patients with varicoceles. Acta Endocrinol. (Copenh.) 1983; 102: 463-9.
29. Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M. Increased testicular 8-hydroxy-2-deoxyguanosine in patients with varicocele. BJU Int. 2007; 100: 863-6.
30. Diemer T, Allen JA, Hales KH, Hales DB. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology 2003; 144: 2882-91.
31. Zheng YQ, Zhang XB, Zhou JQ, Cheng F, Rao T, Yao Y. The effects of artery-ligating and artery-preserving varicocelectomy on the ipsilateral testes in rats. Urology 2008; 72: 1179-84.
32. Cook DJ, Sackett DL, Spitzer WO. Methodologic guidelines for systematic reviews of randomized control trials in health care from the Potsdam Consultation on Meta-Analysis. J. Clin. Epidemiol. 1995; 48: 167-71.