Dose escalation of radiotherapy for Metastatic Spinal Cord Compression (MSCC) in patients with relatively favorable survival prognosis

Strahlentherapie und Onkologie

Volumn 187, Issue 11, 2011, Pages 729-735

  Rades, Dirk ^a,c   Panzner, Annika ^a   Rudat, Volker ^b,c   Karstens, Johann H ^d   Schild, Steven E ^e  

^a UNIVERSITY OF LÜBECK   (Germany)

^b SAAD SPECIALIST HOSPITAL   (Saudi Arabia)

^c UNIVERSITY OF HAMBURG   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e MAYO CLINIC   (United States)

Author keywords

Dose escalation; Metastatic spinal cord compression; Radiotherapy; Survival prognosis

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BONE METASTASIS; BREAST CANCER; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; GENDER; HUMAN; LUNG CANCER; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; METASTATIC SPINAL CORD COMPRESSION; MOBILIZATION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MYELOMA; OVERALL SURVIVAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; RADIATION DOSE; SCORING SYSTEM; SPINAL CORD COMPRESSION; TREATMENT OUTCOME; TUMOR DIAGNOSIS; VERTEBRA;

AGED; BREAST NEOPLASMS; DISABILITY EVALUATION; DISEASE-FREE SURVIVAL; DOSE FRACTIONATION; FEMALE; HUMANS; LUNG NEOPLASMS; LYMPHOMA; MALE; MIDDLE AGED; MULTIPLE MYELOMA; NEUROLOGIC EXAMINATION; PROSTATIC NEOPLASMS; RADIOTHERAPY DOSAGE; RETROSPECTIVE STUDIES; SPINAL CORD COMPRESSION; SPINAL NEOPLASMS; SURVIVAL RATE; SURVIVORS;

EID: 84856214531     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-011-2266-y     Document Type: Article

References (18)

1. Freundt K, Meyners T, Bajrovic A et al. Radiotherapy for oligometastatic disease in patients with spinal cord compression (MSCC) from relatively radioresistant tumors. Strahlenther Onkol 2010;186:218-23.
2. Gerszten PC, Burton SA, Ozhasoglu C et al. Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine 2007;32:193-9. (Pubitemid 46105806)
3. Joiner MC, Van der Kogel AJ. The linear-quadratic approach to fractionation and calculation of isoeffect relationships. In: Steel GG (ed) Basic clinical radiobiology. New York, Oxford University Press, 1997, pp 106-12.
4. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
5. Milker-Zabel S, Zabel A, Thilmann C et al. Clinical results of retreatment of vertebral bone metastases by stereotactic conformal radiotherapy and intensity- modulated radiotherapy. Int J Radiat Oncol Biol Phys 2003;55:162-7. (Pubitemid 36024166)
6. Mirri MA, Arcangeli G, Benassi M et al. Hypofractionated conformal radiotherapy (HCRT) for primary and metastatic lung cancers with small dimension: efficacy and toxicity. Strahlenther Onkol 2009;185:27-33.
7. Nieder C, Haukland E, Pawinski A et al. Validation of new prognostic and predictive scores by sequential testing approach. Strahlenther Onkol 2010, Feb 22 [Epub ahead of print].
8. Patchell R, Tibbs PA, Regine WF et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 2005;366:643-8. (Pubitemid 41176016)
9. Prasad D, Schiff D. Malignant spinal cord compression. Lancet Oncol 2005;6:15-24.
10. Quinn JA, DeAngelis LM. Neurologic emergencies in the cancer patient. Semin Oncol 2000;27:311-21. (Pubitemid 30395164)
11. Rades D, Dunst J, Schild SE. The first score predicting overall survival in patients with metastatic spinal cord compression. Cancer 2008;112:157-61.
12. Rades D, Huttenlocher S, Dunst J et al. Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression. J Clin Oncol 2010;28:3597-604.
13. Rades D, Karstens JH, Hoskin PJ et al. Escalation of radiation dose beyond 30 Gy in 10 fractions for metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 2007;67:525-31. (Pubitemid 46108325)
14. Rades D, Lange M, Veninga T et al. Preliminary results of spinal cord compression recurrence evaluation (SCORE-1) study comparing short-course versus long-course radiotherapy for local control of malignant epidural spinal cord compression. Int J Radiat Oncol Biol Phys 2009;73:228-34.
15. Rades D, Stalpers LJA, Veninga T et al. Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression in a series of 1304 patients. J Clin Oncol 2005;23:3366-75.
16. Souchon R, Wenz F, Sedlmayer F et al. DEGRO practice guidelines for palliative radiotherapy of metastatic breast cancer: bone metastases and metastatic spinal cord compression. Strahlenther Onkol 2009;185:417-24.
17. Tomita T, Galicich JH, Sundaresan N. Radiation therapy for spinal epidural metastases with complete block. Acta Radiol Oncol 1983;22:135-43. (Pubitemid 13039646)
18. Trotti A, Byhardt R, Stetz J et al. Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys 2000;47:13-47. (Pubitemid 30179675)