Escalation of radiation dose beyond 30 Gy in 10 fractions for metastatic spinal cord compression

International Journal of Radiation Oncology Biology Physics

Volumn 67, Issue 2, 2007, Pages 525-531

  Rades, Dirk ^a,b   Karstens, Johann H ^c   Hoskin, Peter J ^d   Rudat, Volker ^e   Veninga, Theo ^f   Schild, Steven E ^g   Dunst, Juergen ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d MOUNT VERNON CANCER CENTRE   (United Kingdom)

^e ST JOSEF HOSPITAL   (Germany)

^f DR BERNARD VERBEETEN INSTITUTE   (Netherlands)

^g MAYO CLINIC   (United States)

Author keywords

Dose escalation; Metastatic spinal cord compression; Outcome

Indexed keywords

BONE; ENZYMES; ONCOLOGY; PATIENT TREATMENT; RADIOTHERAPY; TUMORS;

DOSE ESCALATION; METASTATIC SPINAL CORD COMPRESSION (MSCC); PROGNOSTIC FACTORS; VISCERAL METASTASES;

DOSIMETRY;

ADULT; ARTICLE; BONE METASTASIS; BREAST CANCER; CANCER CONTROL; CANCER DIAGNOSIS; CANCER PATIENT; CANCER SURVIVAL; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; FUNCTIONAL ASSESSMENT; GENDER; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; METASTATIC SPINAL CORD COMPRESSION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION DOSE; RETROSPECTIVE STUDY; SPINAL CORD COMPRESSION; SURVIVAL RATE; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR DIAGNOSIS; VERTEBRA; VISCERAL METASTASIS;

AGED; DOSE FRACTIONATION; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; RECOVERY OF FUNCTION; RETROSPECTIVE STUDIES; SPINAL CORD COMPRESSION; SPINAL NEOPLASMS; TREATMENT OUTCOME;

EID: 33846213099     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.09.025     Document Type: Article

References (21)

1. Maranzano E., and Latini P. Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: Final results from a prospective trial. Int J Radiat Oncol Biol Phys 32 (1995) 959-967
2. Rades D., Karstens J.H., and Alberti W. Role of radiotherapy in the treatment of motor dysfunction due to metastatic spinal cord compression: Comparison of three different radiation schedules. Int J Radiat Oncol Biol Phys 54 (2002) 1160-1164
3. Rades D., Fehlauer F., Stalpers L.J., et al. A prospective evaluation of two radiotherapy schedules with 10 versus 20 fractions for the treatment of metastatic spinal cord compression: Final results of a multicenter study. Cancer 101 (2004) 2687-2692
4. Rades D., Stalpers L.J.A., Veninga T., et al. Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression in a series of 1304 patients. J Clin Oncol 23 (2005) 3366-3375
5. van den Hout W.B., van der Linden Y.M., Steenland E., et al. Single- versus multiple-fraction radiotherapy in patients with painful bone metastases: Cost-utility analysis based on a randomized trial. J Natl Cancer Inst 95 (2003) 222-229
6. Joiner M.C., and van der Kogel A.J. The linear-quadratic approach to fractionation and calculation of isoeffect relationships. In: Steel G.G. (Ed). Basic clinical radiobiology (1997), Oxford University Press, New York 106-112
7. Barendsen G.W. Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 8 (1982) 1981-1997
8. Sørensen P.S., Børgesen S.E., Rohde K., et al. Metastatic epidural spinal cord compression. Cancer 65 (1990) 1502-1508
9. Hoskin P.J., Grover A., and Bhana R. Metastatic spinal cord compression: Radiotherapy outcome and dose fractionation. Radiother Oncol 68 (2003) 175-180
10. Tomita T., Galicich J.H., and Sundaresan N. Radiation therapy for spinal epidural metastases with complete block. Acta Radiol Oncol 22 (1983) 135-143
11. Kaplan E.L., and Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
12. Helweg-Larsen S., Sørensen P.S., and Kreiner S. Prognostic factors in metastatic spinal cord compression: A prospective study using multivariate analysis of variables influencing survival and gait function in 153 patients. Int J Radiat Oncol Biol Phys 46 (2000) 1163-1169
13. Prasad D., and Schiff D. Malignant spinal cord compression. Lancet Oncol 6 (2005) 15-24
14. Rades D., Heidenreich F., and Karstens J.H. Final results of a prospective study of the prognostic value of the time to develop motor deficits before irradiation in metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 53 (2002) 975-979
15. Manabe S., Tanaka H., Higo Y., et al. Experimental analysis of the spinal cord compressed by spinal metastasis. Spine 14 (1989) 1308-1315
16. Brown P.D., Stafford S.L., Schild S.E., et al. Metastatic spinal cord compression in patients with colorectal cancer. J Neurooncol 44 (1999) 175-180
17. Maranzano E., Latini P., Perrucci E., et al. Short-course radiotherapy (8 Gy × 2) in metastatic spinal cord compression: An effective and feasible treatment. Int J Radiat Oncol Biol Phys 38 (1997) 1037-1044
18. Maranzano E., Bellavita R., Rossi R., et al. Short-course versus split-course radiotherapy in metastatic spinal cord compression: Results of a phase III, randomized, multicenter trial. J Clin Oncol 23 (2005) 3358-3365
19. Rades D., Stalpers L.J.A., Hulshof M.C., et al. Comparison of 1 × 8 Gy and 10 × 3 Gy for functional outcome in patients with metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 62 (2005) 514-518
20. Rades D., Stalpers L.J.A., Schulte R., et al. Defining the appropriate radiotherapy regimen for metastatic spinal cord compression (MSCC) in non-small cell lung cancer (NSCLC) patients. Eur J Cancer 42 (2006) 1052-1056
21. Patchell R., Tibbs P.A., Regine W.F., et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: A randomised trial. Lancet 366 (2005) 643-648