The postmenopausal hormone replacement therapy-related breast cancer risk is decreased in women carrying the CYP2C19*17 variant

Breast Cancer Research and Treatment

Volumn 131, Issue 1, 2012, Pages 347-350

  Justenhoven, Christina ^a,b   Obazee, Ofure ^a,b   Winter, Stefan ^a,b   Couch, Fergus J ^c   Olson, Janet E ^c   Hall, Per ^d   Hannelius, Ulf ^d   Li, Jingmei ^d,e   Humphreys, Keith ^d   Severi, Gianluca ^f,g   Giles, Graham ^f,g   Southey, Melissa ^g   Baglietto, Laura ^f,g   Fasching, Peter A ^h,i   Beckmann, Matthias W ⁱ   Ekici, Arif B ^j   Hamann, Ute ^k   Baisch, Christian ^l   Harth, Volker ^m   Rabstein, Sylvia ^m   Lotz, Anne ^m   Pesch, Beate ^m   Brüning, Thomas ^m   Ko, Yon Dschun ^l   Brauch, Hiltrud ^a,b   more..

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c MAYO CLINIC   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e GENOME INSTITUTE OF SINGAPORE   (Singapore)

^f CANCER EPIDEMIOLOGY CENTRE   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^j UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^k GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^l Johanniter Krankenhaus   (Germany)

^m INSTITUT DER RUHR UNIVERSITÄT BOCHUM IPA   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; GESTAGEN;

BIOASSAY; BREAST CANCER; CANCER REGISTRY; CANCER RISK; CYTOCHROME P450 2C19 GENE; DISEASE ASSOCIATION; DRUG EFFECT; GENE FREQUENCY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HORMONE SUBSTITUTION; HUMAN; LETTER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR PATHOLOGY; ONCOGENE; POSTMENOPAUSE; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; RISK REDUCTION;

ARYL HYDROCARBON HYDROXYLASES; BREAST NEOPLASMS; ESTROGEN REPLACEMENT THERAPY; FEMALE; GONADAL STEROID HORMONES; HUMANS; POSTMENOPAUSE; RISK;

EID: 84856210137     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1827-1     Document Type: Letter

References (25)

1. TJ Key NE Allen EA Spencer RC Travis 2002 The effect of diet on risk of cancer Lancet 360 861 868 12243933 10.1016/S0140-6736(02)09958-0 1:CAS:528:DC%2BD38XntVWms78%3D (Pubitemid 35257961)
2. RT Chlebowski LH Kuller RL Prentice ML Stefanick JE Manson M Gass AK Aragaki JK Ockene DS Lane GE Sarto A Rajkovic R Schenken SL Hendrix PM Ravdin TE Rohan S Yasmeen G Anderson 2009 Breast cancer after use of estrogen plus progestin in postmenopausal women N Engl J Med 360 573 587 19196674 10.1056/NEJMoa0807684 1:CAS:528:DC%2BD1MXhsFyiur8%3D
3. RT Chlebowski GL Anderson M Gass DS Lane AK Aragaki LH Kuller JE Manson ML Stefanick J Ockene GE Sarto KC Johnson J Wactawski-Wende PM Ravdin R Schenken SL Hendrix A Rajkovic TE Rohan S Yasmeen RL Prentice 2010 Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women JAMA 304 1684 1692 20959578 10.1001/jama.2010.1500 1:CAS:528:DC%2BC3cXhtlarurzP
4. JE Rossouw GL Anderson RL Prentice AZ LaCroix C Kooperberg ML Stefanick RD Jackson SA Beresford BV Howard KC Johnson JM Kotchen J Ockene 2002 Writing group for the Women's Health Initiative investigators risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial JAMA 288 321 333 12117397 10.1001/jama.288.3.321 1:CAS:528:DC%2BD38Xltlegs7k%3D (Pubitemid 34761611)
5. AZ LaCroix RT Chlebowski JE Manson AK Aragaki KC Johnson L Martin KL Margolis ML Stefanick R Brzyski JD Curb BV Howard CE Lewis J Wactawski-Wende 2011 Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial JAMA 305 1305 1314 21467283 10.1001/jama.2011.382 1:CAS:528:DC%2BC3MXkvFehurc%3D
6. VC Jordan LG Ford 2011 Paradoxical clinical effect of estrogen on breast cancer risk: a "New" biology of estrogen-induced apoptosis Cancer Prev Res 4 633 637 10.1158/1940-6207.CAPR-11-0185 1:CAS:528:DC%2BC3MXnslekt7c%3D
7. JS Lewis-Wambi VC Jordan 2009 Estrogen regulation of apoptosis: how can one hormone stimulate and inhibit? Breast Cancer Res 11 206 19519952 10.1186/bcr2255
8. Jr. Pasqualini 2007 Progestins and breast cancer Gynecol Endocrinol 23 Suppl 1 32 41 17943537 10.1080/09513590701585003 1:CAS:528:DC%2BD2sXht1eqsrzN (Pubitemid 47613718)
9. JP Wiebe 2006 Progesterone metabolites in breast cancer Endocr Relat Cancer 13 717 738 16954427 10.1677/erc.1.01010 1:CAS:528:DC%2BD28XhtlequrzM (Pubitemid 44763254)
10. ZN Cheng Y Shu ZQ Liu LS Wang DS Ou-Yang HH Zhou 2001 Role of cytochrome P450 in estradiol metabolism in vitro Acta Pharmacol Sin 22 148 154 11741520 1:CAS:528:DC%2BD3MXht1Kkt7s%3D (Pubitemid 32158354)
11. AE Cribb MJ Knight D Dryer J Guernsey K Hender M Tesch TM Saleh 2006 Role of polymorphic human cytochrome P450 enzymes in estrone oxidation Cancer Epidemiol Biomark Prev 15 551 558 10.1158/1055-9965.EPI-05-0801 1:CAS:528:DC%2BD28Xit1OmsL0%3D
12. H Yamazaki T Shimada 1997 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes Arch Biochem Biophys 346 161 169 9328296 10.1006/abbi.1997.0302 1:CAS:528:DyaK2sXmsVeitrg%3D (Pubitemid 27415307)
13. PJ Wedlund 2000 The CYP2C19 enzyme polymorphism Pharmacology 61 174 183 10971203 10.1159/000028398 1:CAS:528:DC%2BD3cXntlCgsbY%3D
14. SM De Morais GR Wilkinson J Blaisdell UA Meyer K Nakamura JA Goldstein 1994 Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese Mol Pharmacol 46 594 598 7969038 (Pubitemid 24334747)
15. PL Roddam S Rollinson E Kane E Roman A Moorman R Cartwright GJ Morgan 2000 Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia Pharmacogenetics 10 605 615 11037802 10.1097/00008571-200010000-00004 1:CAS:528:DC%2BD3cXnsFCrtbg%3D
16. SC Sim C Risinger ML Dahl E Aklillu M Christensen L Bertilsson M Ingelman-Sundberg 2006 A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants Clin Pharmacol Ther 79 103 113 16413245 10.1016/j.clpt.2005.10. 002 1:CAS:528:DC%2BD28XksVGltw%3D%3D (Pubitemid 43069582)
17. C Justenhoven U Hamann CB Pierl C Baisch V Harth S Rabstein A Spickenheuer B Pesch T Bruning S Winter YD Ko H Brauch 2009 CYP2C19*17 is associated with decreased breast cancer risk Breast Cancer Res Treat 115 391 396 18521743 10.1007/s10549-008-0076-4 1:CAS:528:DC%2BD1MXmsVCqu7Y%3D
18. C Justenhoven CB Pierl S Haas HP Fischer C Baisch U Hamann V Harth B Pesch T Bruning C Vollmert T Illig J Dippon YD Ko H Brauch 2008 The CYP1B1-1358-GG genotype is associated with estrogen receptor-negative breast cancer Breast Cancer Res Treat 111 171 177 17922187 10.1007/s10549-007-9762-x 1:CAS:528:DC%2BD1cXos1Wntrc%3D (Pubitemid 352009231)
19. B Pesch Y Ko H Brauch U Hamann V Harth S Rabstein C Pierl HP Fischer C Baisch C Justenhoven U Ranft T Bruning 2005 Factors modifying the association between hormone-replacement therapy and breast cancer risk Eur J Epidemiol 20 699 711 16151884 10.1007/s10654-005-0032-0 (Pubitemid 41266867)
20. S Wedren L Lovmar K Humphreys C Magnusson H Melhus AC Syvanen A Kindmark U Landegren ML Fermer F Stiger I Persson J Baron E Weiderpass 2004 Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: a case control study Breast Cancer Res 6 R437 R449 15217512 10.1186/bcr811 1:CAS:528:DC%2BD2cXmtVWqs7o%3D
21. JE Olson CX Ma LL Pelleymounter DJ Schaid VS Pankratz RA Vierkant ZS Fredericksen JN Ingle Y Wu F Couch TA Sellers RM Weinshilboum CM Vachon 2007 A comprehensive examination of CYP19 variation and breast density Cancer Epidemiol Biomark Prev 16 623 625 10.1158/1055-9965.EPI-06-0781 1:CAS:528: DC%2BD2sXjt1Srtb8%3D (Pubitemid 46548672)
22. GG Giles DR English 2002 The Melbourne Collaborative Cohort Study IARC Sci Publ 156 69 70 12484128 1:STN:280:DC%2BD38jit1eqtw%3D%3D
23. M Schrauder S Frank PL Strissel MP Lux MR Bani C Rauh CC Sieber K Heusinger A Hartmann R Schulz-Wendtland R Strick MW Beckmann PA Fasching 2008 Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer J Cancer Res Clin Oncol 134 873 882 18264724 10.1007/s00432-008- 0355-9 1:CAS:528:DC%2BD1cXmslWkt7w%3D
24. TJ Key 2011 Endogenous oestrogens and breast cancer risk in premenopausal and postmenopausal women Steroids 76 812 815 21477610 10.1016/j.steroids.2011. 02.029 1:CAS:528:DC%2BC3MXnsVCgtrk%3D
25. M Kurzawski B Gawronska-Szklarz J Wrzesniewska A Siuda T Starzynska M Drozdzik 2006 Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patients Eur J Clin Pharmacol 62 877 880 16912869 10.1007/s00228-006-0183-2 1:CAS:528:DC%2BD28XhtVeqsb%2FK (Pubitemid 44521437)