Tranexamic acid - a recipe for saving lives in traumatic bleeding

Journal of Tehran University Heart Center

Volumn 6, Issue 4, 2011, Pages 178-

  Roberts, Ian ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

AWARENESS; BLEEDING; BLOOD TRANSFUSION; BLOOD VESSEL OCCLUSION; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; DEATH; DRUG INDICATION; DRUG MECHANISM; EARLY INTERVENTION; EDITORIAL; ELECTIVE SURGERY; FIBRINOLYSIS; HUMAN; MENSTRUATION; MORTALITY; PHYSICIAN ATTITUDE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK REDUCTION; TRAUMATIC BLEEDING; TREATMENT OUTCOME;

EID: 84856198969     PISSN: 17358620     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (6)

1. Okamoto S, Okamoto U. Amino-methyl-cyclohexane-carbolic acid: AMCHA. A new potent inhibitor of fibrinolysis. Keio J Med 1962;11:105-115.
2. Henry DA, Carless PA, Moxey AJ, O' Connell D, Strokes BJ, Fergusson DA, Ker K. Anti-fi brinolytic use for minimizing perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2007; 4: CD001886.
3. The CRASH-2 Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomized, placebo-controlled trial. Lancet 2010;376:23-32.
4. The CRASH-2 Collaborators. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomized controlled trial. Lancet 2011;377:1096-1101.
5. Summary of the report of the 18th meeting of the WHO Expert Committee on the Selection and Use of Essential Medicines (http://www.who.int/selection_medicines/committees/expert/18/en/index.html(22 August 2011).
6. Guerriero C, Cairns J, Perel P, Shakur H, Roberts I. Costeffectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 Trial. PLoS ONE 2011;6:e18987.