Most HIV type 1 non-B infections in the spanish cohort of antiretroviral treatment-naïve HIV-infected Patients (CoRIS) are due to recombinant viruses

Journal of Clinical Microbiology

Volumn 50, Issue 2, 2012, Pages 407-413

  Yebra, Gonzalo ^a   De Mulder, Miguel ^a   Martín, Leticia ^a   Rodríguez, Carmen ^b   Labarga, Pablo ^c   Viciana, Isabel ^d   Berenguer, Juan ^e   Alemán, María Remedios ^f   Pineda, Juan Antonio ^g   García, Federico ^h   Holguín, África ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b CENTRO SANITARIO SANDOVAL   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^e HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^f HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^g HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^h HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL THERAPY; ARTICLE; COHORT ANALYSIS; FEMALE; GENE CLUSTER; GENE SEQUENCE; HIV TYPE 1 NON B INFECTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; MOSAICISM; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; SPAIN; STRUCTURAL GENE; VIRUS DETECTION; VIRUS RECOMBINANT;

CLUSTER ANALYSIS; COHORT STUDIES; FEMALE; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MALE; PHYLOGENY; POL GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PROSPECTIVE STUDIES; RECOMBINATION, GENETIC; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; SPAIN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84856188509     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.05798-11     Document Type: Article

References (57)

1. Annaz HE, et al. 2011. Presence of drug resistance mutations among drug-naïve patients in Morocco. AIDS Res. Hum. Retroviruses 27:917-920.
2. Baeten JM, et al. 2007. HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads. J. Infect. Dis. 195:1177-1180. (Pubitemid 46543449)
3. Brennan CA, Yamaguchi J, Devare SG, Foster GA, Stramer SL. 2010. Expanded evaluation of blood donors in the United States for human immunodeficiency virus type 1 non-B subtypes and antiretroviral drugresistant strains: 2005 through 2007. Transfusion 50:2707-2712.
4. Bruselles A, et al. 2009. Use of massive parallel pyrosequencing for near full-length characterization of a unique HIV type 1 BF recombinant associated with a fatal primary infection. AIDS Res. Hum. Retroviruses 25: 937-942.
5. Candotti D, et al. 2000. AIDS in an HIV-seronegative Ghanaian woman with intersubtype A/G recombinant HIV-1 infection. J. Med. Virol. 62:1-8.
6. Carobene MG, Rodrigues CR, De Candia CA, Turk G, Salomon H. 2009. In vitro dynamics of HIV-1 BF intersubtype recombinants genomic regions involved in the regulation of gene expression. Virol. J. 6:107.
7. Caro-Murillo AM, et al. 2007. Spanish cohort of naive HIV-infected patients (CoRIS): rationale, organization and initial results. Enferm. Infecc. Microbiol. Clin. 25:23-31. (Pubitemid 46232687)
8. Caro-Murillo AM, et al. 2009. HIV infection in immigrants in Spain: epidemiological characteristics and clinical presentation in the CoRIS Cohort (2004 -2006). Enferm. Infecc. Microbiol. Clin. 27:380-388.
9. Champenois K, et al. 2008. Expected response to protease inhibitors of HIV-1 non-B subtype viruses according to resistance algorithms. AIDS 22:1087-1089. (Pubitemid 351769750)
10. Delgado E, et al. 2008. High prevalence of unique recombinant forms of HIV-1 in Ghana: molecular epidemiology from an antiretroviral resistance study. J. Acquir. Immune Defic. Syndr. 48:599-606.
11. Delgado E, et al. 2002. Identification of a newly characterized HIV-1BG intersubtype circulating recombinant form in Galicia, Spain, which exhibits a pseudotype-like virion structure. J. Acquir. Immune Defic. Syndr. 29:536-543. (Pubitemid 34456347)
12. Djoko CF, et al. 2010. HIV type 1 pol gene diversity and genotypic antiretroviral drug resistance mutations in Malabo, Equatorial Guinea. AIDS Res. Hum. Retroviruses 26:1027-1031.
13. European Centre for Disease Prevention and Control/WHO Regional Office for Europe. 2010. HIV/AIDS surveillance in Europe 2009. European Centre for Disease Prevention and Control, Stockholm, Sweden. http://ecdc .europa.eu/en/publications/Publications/101129-SUR-HIV-2009.pdf.
14. Fernández-GarcíA A, et al. 2010. Identification of a new HIV type 1 circulating BF intersubtype recombinant form (CRF47-BF) in Spain. AIDS Res. Hum. Retroviruses 26:827-832.
15. Frange P, et al. 2008. New and old complex recombinant HIV-1 strains among patients with primary infection in 1996-2006 in France: the French ANRS CO06 PRIMO cohort study. Retrovirology 5:69.
16. García F, et al. 2011. Transmission of HIV drug resistance and non-B subtype distribution in the Spanish cohort of antiretroviral treatment naive HIV-infected individuals (CoRIS). Antiviral Res. 91:150-153.
17. Gonzalez LM, et al. 2008. Impact of HIV-1 protease mutations A71V/T and T74S on M89I/V-mediated protease inhibitor resistance in subtype G isolates. J. Antimicrob. Chemother. 61:1201-1204. (Pubitemid 351753582)
18. González-Alba JM, et al. 2011. Molecular surveillance of HIV-1 in Madrid, Spain: a phylogeographic analysis. J. Virol. 85:10755-10763.
19. Grossman Z, et al. 2004. Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir. Antimicrob. Agents Chemother. 48:2159-2165. (Pubitemid 38691614)
20. Hemelaar J, Gouws E, Ghys PD, Osmanov S. 2011. Global trends in molecular epidemiology of HIV-1 during 2000-2007. AIDS 25:679-689.
21. Holguín Á, Álvarez A, Soriano V. 2005. Differences in the length of gag proteins among different HIV type 1 subtypes. AIDS Res. Hum. Retroviruses 21:886-893. (Pubitemid 43150322)
22. Holguín Á, Álvarez A, Soriano V. 2002. HIV-1 subtype J recombinant viruses in Spain. AIDS Res. Hum. Retroviruses 18:523-529. (Pubitemid 34499730)
23. Holguín Á, de Mulder M, Yebra G, López M, Soriano V. 2008. Increase of non-B subtypes and recombinants among newly diagnosed HIV-1 native Spaniards and immigrants in Spain. Curr. HIV Res. 6:327-334.
24. Holguín Á, et al. 2008. Genetic characterization of complex interrecombinant HIV-1 strains circulating in Spain and reliability of distinct rapid subtyping tools. J. Med. Virol. 80:383-391. (Pubitemid 351206885)
25. Holguín Á, Sune C, Hamy F, Soriano V, Klimkait T. 2006. Natural polymorphisms in the protease gene modulate the replicative capacity of non-B HIV-1 variants in the absence of drug pressure. J. Clin. Virol. 36: 264-271. (Pubitemid 44066898)
26. Kantor R, Katzenstein D. 2003. Polymorphism in HIV-1 non-subtype B protease and reverse transcriptase and its potential impact on drug susceptibility and drug resistance evolution. AIDS Rev. 5:25-35. (Pubitemid 36873892)
27. Kinomoto M, et al. 2005. HIV-1 proteases from drug-naive West African patients are differentially less susceptible to protease inhibitors. Clin. Infect. Dis. 41:243-251. (Pubitemid 40962507)
28. Konings FAJ, et al. 2006. Human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02-AG (CRF02-AG) has a higher in vitro replicative capacity than its parental subtypes A and G. J. Med. Virol. 78:523-534.
29. Leoz M, et al. 2011. Circulation of multiple patterns of unique recombinant forms B/CRF02-AG in France: precursor signs of the emergence of an upcoming CRF B/02. AIDS 25:1371-1377.
30. Lospitao E, Álvarez A, Soriano V, Holguín A. 2005. HIV-1 subtypes in Spain: a retrospective analysis from 1995 to 2003. HIV Med. 6:313-320. (Pubitemid 41335139)
31. McConnell MJ, et al. 2008. Molecular epidemiology of HIV type 1 in newly diagnosed patients in southern Spain. AIDS Res. Hum. Retroviruses 24:881-887. (Pubitemid 351871678)
32. Onafuwa-Nuga A, Telesnitsky A. 2009. The remarkable frequency of human immunodeficiency virus type 1 genetic recombination. Microbiol. Mol. Biol. Rev. 73:451-480.
33. Pérez-Álvarez L, et al. 2003. High incidence of non-B and recombinant HIV-1 strains in newly diagnosed patients in Galicia, Spain: study of genotypic resistance. Antivir. Ther. 8:355-360. (Pubitemid 37101640)
34. Pérez-Álvarez L, et al. 2006. Prevalence of transmitted drug resistance and HIV-1 genetic forms in newly diagnosed individuals from Galicia and the Basque Country, Spain, abstr. 23. 4th European HIV Drug Resistance Workshop, Monte Carlo, Monaco, 29 to 31 March 2006.
35. Piantadosi A, Ngayo MO, Chohan B, Overbaugh J. 2008. Examination of a second region of the HIV type 1 genome reveals additional cases of superinfection. AIDS Res. Hum. Retroviruses 24:1221-1224.
36. Plantier JC, et al. 2009. A new human immunodeficiency virus derived from gorillas. Nat. Med. 15:871-872.
37. Ramirez BC, Simon-Loriere E, Galetto R, Negroni M. 2008. Implications of recombination for HIV diversity. Virus Res. 134:64-73.
38. Registro Nacional de Casos de Sida. 2010. Vigilancia epidemioló gica del VIH en España: nuevos diagnósticos de VIH en España, período 2003-2009. Actualización 30 de junio de 2010. Centro Nacional de Epidemiología, Madrid, Spain. http://www.msps.es/ciudadanos/ enfLesiones/enf Transmisibles/sida/vigilancia/SINIVIH-junio2010.pdf.
39. Rouet F, et al. 2007. Impact of HIV-1 genetic diversity on plasma HIV-1 RNAquantification: usefulness of the Agence Nationale de Recherches sur le SIDA second-generation long terminal repeat-based real-time reverse transcriptase polymerase chain reaction test. J. Acquir. Immune Defic. Syndr. 45:380-388. (Pubitemid 47057665)
40. Sacktor N, et al. 2009. HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda. Clin. Infect. Dis. 49:780-786.
41. Sagoe KW, Dwidar M, Adiku TK, Arens MQ. 2009. HIV-1 CRF 02 AG polymerase genes in Southern Ghana are mosaics of different 02 AG strains and the protease gene cannot infer subtypes. Virol. J. 6:27.
42. Simon-Loriere E, et al. 2009. Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus. PLoS Pathog. 5:e1000418.
43. Snoeck J, et al. 2006. Discordances between interpretation algorithms for genotypic resistance to protease and reverse transcriptase inhibitors of human immunodeficiency virus are subtype dependent. Antimicrob. Agents Chemother. 50:694-701. (Pubitemid 43190984)
44. Tee KK, et al. 2009. Estimating the date of origin of an HIV-1 circulating recombinant form. Virology 387:229-234.
45. Thomson MM, Nájera R. 2007. Increasing HIV-1 genetic diversity in Europe. J. Infect. Dis. 196:1120-1124. (Pubitemid 47580265)
46. UNAIDS. 2010. Global report: UNAIDS report on the global AIDS epidemic 2010. UNAIDS, Geneva, Switzerland. http://www.unaids.org /documents/20101123- GlobalReport-em.pdf.
47. van de Vijver DAMC, et al. 2005. Differences in the frequency of minor substitutions between HIV-1 subtypes and their potential impact on the genetic barrier for resistance to protease inhibitors. Antivir. Ther. 10(Suppl. 1):S145.
48. Vasan A, et al. 2006. Different rates of disease progression of HIV type 1 infection in Tanzania based on infecting subtype. Clin. Infect. Dis. 42:843-852. (Pubitemid 43363943)
49. Vercauteren J, et al. 2009. Transmission of drug-resistant HIV-1 is stabilizing in Europe. J. Infect. Dis. 200:1503-1508.
50. Vijay NN, Vasantika, Ajmani R, Perelson AS, Dixit NM. 2008. Recombination increases human immunodeficiency virus fitness, but not necessarily diversity. J. Gen. Virol. 89:1467-1477.
51. Wensing AM, et al. 2005. Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management. J. Infect. Dis. 192:958-966. (Pubitemid 41266791)
52. Yebra G, de Mulder M, del Romero J, Rodríguez C, Holguín Á. 2010. HIV-1 non-B subtypes: high transmitted NNRTI-resistance in Spain and impaired genotypic resistance interpretation due to variability. Antiviral Res. 85:409-417.
53. Yebra G, et al. 2009. Clinical differences and viral diversity between newly HIV type 1-diagnosed African and non-African patients in Spain (2005-2007). AIDS Res. Hum. Retroviruses 25:37-44.
54. Yerly S, et al. 2007. Transmission of HIV-1 drug resistance in Switzerland: a 10-year molecular epidemiology survey. AIDS 21:2223-2229. (Pubitemid 350287221)
55. Zhang C, Ding N, Wei JF. 2008. Different sliding window sizes and inappropriate subtype references result in discordant mosaic maps and breakpoint locations of HIV-1 CRFs. Infect. Genet. Evol. 8:693-697.
56. Zhang M, et al. 2010. The role of recombination in the emergence of a complex and dynamic HIV epidemic. Retrovirology 7:25.
57. Zhuang J, et al. 2002. Human immunodeficiency virus type 1 recombination: rate, fidelity, and putative hot spots. J. Virol. 76:11273-11282. (Pubitemid 35231282)